Effects of lycopene, a carotenoid, on intrathymic T cell differentiation and peripheral CD4/CD8 ratio in a high mammary tumor strain of SHN retired mice

Kobayashi, T.; lijima, Koji; Mitamura, T; Toriizuka, Kazuo; Cyong, Jong‐Choi; Nagasawa, Hiroshi

doi:10.1097/00001813-199603000-00008

Cited by 17 publications

(16 citation statements)

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“…Giovannucci reviewed data from clinical and epidemiological studies and found that most of these studies show an inverse association between tomato intake or blood lycopene level and the risk of cancer . These epidemiological data are reinforced by studies showing the inhibitory e ect of lycopene on tumor cell growth in vitro (Amir et al, 1999;Countryman et al, 1991; and in vivo (Kim et al, 1997;Kobayashi et al, 1996;Nagasawa et al, 1995;Narisawa et al, 1996;Sharoni et al, 1997;.…”

Section: Introductionmentioning

confidence: 96%

Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27Kip1 in the cyclin E–cdk2 complexes

et al. 2001

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Numerous studies have demonstrated the anticancer activity of the tomato carotenoid, lycopene. However, the molecular mechanism of this action remains unknown. Lycopene inhibition of human breast and endometrial cancer cell growth is associated with inhibition of cell cycle progression at the G 1 phase. In this study we determined the lycopene-mediated changes in the cell cycle machinery. Cells synchronized in the G 1 phase by serum deprivation were treated with lycopene or vehicle and restimulated with 5% serum. Lycopene treatment decreased serum-induced phosphorylation of the retinoblastoma protein and related pocket proteins. This e ect was associated with reduced cyclin-dependent kinase (cdk4 and cdk2) activities with no alterations in CDK protein levels. Lycopene caused a decrease in cyclin D1 and D3 levels whereas cyclin E levels did not change. The CDK inhibitor p21 Cip1/Waf1 abundance was reduced while p27 Kip1 levels were unaltered in comparison to control cells. Serum stimulation of control cells resulted in reduction in the p27 content in the cyclin E ± cdk2 complex and its accumulation in the cyclin D1 ± cdk4 complex. This change in distribution was largely prevented by lycopene treatment. These results suggest that lycopene inhibits cell cycle progression via reduction of the cyclin D level and retention of p27 in cyclin E ± cdk2, thus leading to inhibition of G 1 CDK activities. Oncogene (2001) 20, 3428 ± 3436.

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Section: Introductionmentioning

confidence: 96%

Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27Kip1 in the cyclin E–cdk2 complexes

et al. 2001

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“…[9][10][11][12] In a clinical trial at Hanoi University in Vietnam, 13) an oil extract of Gac was found to be eŠective in the treatment of liver cancer.…”

mentioning

confidence: 99%

Carotenoid Pigments in GAC Fruit (Momordica cochinchinensisSPRENG)

Aoki

Kieu

Kuze

et al. 2002

Bioscience, Biotechnology, and Biochemistry

108

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“…Given that upregulation of GJC is correlated with growth inhibition of precancerous cells, lycopene could also act as anticarcinogen [29,30]. Research findings showing an inverse relationship between cancer and lycopene are based on epidemiological [31], cell culture [2] and animal studies [32,33]. Specifically, lycopene was shown to be an inhibitor of endometrial, mammary and lung human cancer cell proliferation, and a suppressor of insulin-like growth factor-I [34].…”

Section: Lycopene As Functional Ingredient: Structure Properties Andmentioning

confidence: 99%

Lycopene in Beverage Emulsions: Optimizing Formulation Design and Processing Effects for Enhanced Delivery

Meroni

Raikos

2018

Beverages

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Abstract:Lycopene is a desired ingredient in food formulations, yet its beneficial effects on human health remain largely underexploited due to its poor chemical stability and bioavailability. Oil-in-water emulsions may offer multiple advantages for the incorporation and delivery of this carotenoid species. Engineering and processing aspects for the development of emulsion-based delivery systems are of paramount importance for maintaining the structural integrity of lycopene. The selection of emulsifiers, pH, temperature, oil phase, particle size, homogenization conditions and presence of other antioxidants are major determinants for enhancing lycopene stability and delivery from a food emulsion. Process and formulation optimization of the delivery system is product-specific and should be tailored accordingly. Further research is required to better understand the underlying mechanisms of lycopene absorption by the human digestive system.

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Effects of lycopene, a carotenoid, on intrathymic T cell differentiation and peripheral CD4/CD8 ratio in a high mammary tumor strain of SHN retired mice

Cited by 17 publications

References 0 publications

Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27Kip1 in the cyclin E–cdk2 complexes

Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27Kip1 in the cyclin E–cdk2 complexes

Carotenoid Pigments in GAC Fruit (Momordica cochinchinensisSPRENG)

Lycopene in Beverage Emulsions: Optimizing Formulation Design and Processing Effects for Enhanced Delivery

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