Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice

Hashemzaei, Mahmoud; Abdollahzadeh, Mina; Iranshahi, Mehrdad; Golmakani, Ebrahim; Rezaee, Ramin; Tabrizian, Kaveh

doi:10.1515/jcim-2016-0066

Cited by 20 publications

(14 citation statements)

References 32 publications

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“…In addition to diarrhoea, luteolin also reversed the mechanical hypersensitivity induced by irinotecan. Indeed, the anti‐nociceptive effects of luteolin have been described in several models of pain (Fan et al, ; Hashemzaei et al, ), highlighting the potential of the compound in pain management. Wardill et al () demonstrated that the hypersensitivity induced by irinotecan treatment is dependent on activation of TLR4.…”

Section: Discussionmentioning

confidence: 99%

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Boeing

Souza

Speca

et al. 2020

British J Pharmacology

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Background and Purpose: Intestinal mucositis refers to mucosal damage caused by cancer treatment, and irinotecan is one of the agents most associated with this condition. Focusing on the development of alternatives to prevent this important adverse effect, we evaluated the activity of the flavonoid luteolin, which has never been tested for this purpose despite its biological potential. Experimental Approach: The effects of luteolin were examined on irinotecaninduced intestinal mucositis in mice. Clinical signs were evaluated. Moreover, histological, oxidative, and inflammatory parameters were analysed, as well as the possible interference of luteolin in the anti-tumour activity of irinotecan. Key Results: Luteolin (30 mgÁkg −1 ; p.o. or i.p.) prevented irinotecan-induced intestinal damage by reducing weight loss and diarrhoea score and attenuating the shortening of the duodenum and colon. Histological analysis confirmed that luteolin (p.o.)prevented villous shortening, vacuolization, and apoptosis of cells and preserved mucin production in the duodenum and colon. Moreover, luteolin treatment mitigated irinotecan-induced oxidative stress, by reducing the levels of ROS and LOOH and augmenting endogenous antioxidants, and inflammation by decreasing MPO enzymic activity, TNF, IL-1β, and IL-6 levels and increasing IL-4 and IL-10. Disruption of the tight junctions ZO-1 and occludin was also prevented by luteolin treatment.Importantly, luteolin did not interfere with the anti-tumour activity of irinotecan. Conclusion and Implications: Luteolin prevents intestinal mucositis induced byirinotecan and therefore could be a potential adjunct in anti-tumour therapy to control this adverse effect, increasing treatment adherence and consequently the chances of cancer remission.

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Section: Discussionmentioning

confidence: 99%

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Boeing

Souza

Speca

et al. 2020

British J Pharmacology

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“…Natural products have attracted attention for their protective effects on the brain and heart caused via different mechanisms including antioxidant and antiinflammatory effects, and regulation of apoptosis and autophagy (Bastianetto et al , ; Hashemzaei et al , ; Hashemzaei et al , ; Sinha et al , ). Resveratrol (RES) (trans‐3, 4, 5‐trihydroxystilbene) is a natural polyphenolic phytoalexin that is found in black grape skin (Gu et al , ).…”

Section: Introductionmentioning

confidence: 99%

“…Natural products have attracted attention for their protective effects on the brain and heart caused via different mechanisms including antioxidant and antiinflammatory effects, and regulation of apoptosis and autophagy (Bastianetto et al, 2015;Hashemzaei et al, 2017a;Hashemzaei et al, 2017b;Sinha et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Neuro‐Protective Effects of Resveratrol on Carbon Monoxide‐Induced Toxicity in Male Rats

Tabrizian

Shahraki

Bazzi

et al. 2017

Phytotherapy Research

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Acute carbon monoxide (CO) poisoning causes neurotoxicity through induction of necrosis, apoptosis, lipid peroxidation and oxidative stress. Resveratrol (RES) is a natural polyphenolic phytoalexin that exhibits neuroprotective effects in ischemia/reperfusion due to its anti-apoptotic, anti-necrotic and strong anti-oxidant properties as well as its ability to activate pro-survival pathways. In this study, rats were exposed to CO 3000 ppm for 1 h. Immediately after poisoning and on the next four consecutive days, RES (1, 5 and 10 mg/kg) was administered intraperitoneally. On the fifth day, animals' brains were excised, and necrosis, lipid peroxidation level and the level of Akt, BAX and BCL2 expression were evaluated. The results showed that RES 10 mg/kg significantly reduced lipid peroxidation, but RES 1 and 5 mg/kg had no significant effect on this parameter. Furthermore, RES 5 and 10 mg/kg significantly increased Akt expression level, while BAX/BCL2 ratio was reduced by RES 1, 5 and 10 mg/kg. Moreover, RES reduced necrotic foci in the brain, but the best results were seen following treatment with RES 10 mg/kg. In summary, RES showed neuroprotective effect in CO-poisoned rats as it decreased necrosis and BAX/BCL2 ratio and increased Akt expression levels. Copyright © 2017 John Wiley & Sons, Ltd.

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“…In addition, this flavone can also be used in combination with these two classical treatment options to yield better results [ 124 ]. Beneficial effects induced by luteolin were also in a neuropathic pain model, where luteolin administration was found to reduce neuropathic pain, also potentiating the effects of morphine [ 125 ].…”

Section: Preclinical Pharmacological Activities Of Luteolin: In Vivo Evidencementioning

confidence: 99%

Paving Luteolin Therapeutic Potentialities and Agro‐Food‐Pharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits

Taheri

Sharifi‐Rad

Antika

et al. 2021

Oxidative Medicine and Cellular Longevity

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Luteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing to their biological and pharmacological value. Many preclinical studies report that luteolin present excellent antioxidant, anticancer, antimicrobial, neuroprotective, cardioprotective, antiviral, and anti-inflammatory effects, and as a consequence, various clinical trials have been designed to investigate the therapeutic potential of luteolin in humans. However, luteolin has a very limited bioavailability, which consequently affects its biological properties and efficacy. Several drug delivery strategies have been developed to raise its bioavailability, with nanoformulations and lipid carriers, such as liposomes, being the most intensively explored. Pharmacological potential of luteolin in various disorders has also been underlined, but to some of them, the exact mechanism is still poorly understood. Given the great potential of this natural antioxidant in health, this review is aimed at providing an extensive overview on the in vivo pharmacological action of luteolin and at stressing the main features related to its bioavailability, absorption, and metabolism, while essential steps determine its absolute health benefits and safety profiles. In addition, despite the scarcity of studies on luteolin bioavailability, the different drug delivery formulations developed to increase its bioavailability are also listed here.

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Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice

Cited by 20 publications

References 32 publications

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Neuro‐Protective Effects of Resveratrol on Carbon Monoxide‐Induced Toxicity in Male Rats

Paving Luteolin Therapeutic Potentialities and Agro‐Food‐Pharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits

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