2018
DOI: 10.4314/tjpr.v17i5.8
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Effects of <i>tMa-Xin-Di-Tan</i> decoction on ovalbumin-induced allergic asthma in mice

Abstract: Purpose: To investigate the effect of the Ma-Xin-Di-Tan (MXDT) decoction on ovalbumin-induced allergic asthma (AA) in mice. Methods: Asthma was induced in mice by ovalbumin (OVA) injection, and different doses of MXDT (150, 300, and 600 mg/kg/day) were administered orally for 28 days. Pathological changes in lung tissues were examined, while levels of cytokines, including interleukin (IL)-4, IL-6, IL-17, interferon (IFN)-γ, and transforming growth factor (TGF)-β, were determined using enzyme-linked immunosorbe… Show more

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Cited by 1 publication
(2 citation statements)
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“…Previous reports reveal that an imbalance of Th1/Th2 is crucial for allergic asthma and that a decrease in the cytokines released by Th2 cells, (e.g., IL-4, IL-6, and IL-13) could be helpful for controlling asthma. Thus, the appropriate ratio of Th1/Th2 is also beneficial for management of allergic diseases [15,16,18].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Previous reports reveal that an imbalance of Th1/Th2 is crucial for allergic asthma and that a decrease in the cytokines released by Th2 cells, (e.g., IL-4, IL-6, and IL-13) could be helpful for controlling asthma. Thus, the appropriate ratio of Th1/Th2 is also beneficial for management of allergic diseases [15,16,18].…”
Section: Discussionmentioning
confidence: 99%
“…The protocol was carried out following published methods with some modifications [15,16]. To induce asthma in rats, animals were treated with a mixture of 50 mg of OVA and 2 mg of aluminum hydroxide by intraperitoneal injection (ip) on the 1 st and 14 th days of the experiment.…”
Section: Animal Studiesmentioning
confidence: 99%