Effects of &lt;i&gt;N&lt;/i&gt;-(2-Mercaptopropionyl) Glycine on Neutrophil Locomotion

Patrone, Franco; Dallegri, Franco; Lanzi, Gianfranco; Sacchetti, C.

doi:10.1159/000232702

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…The observation in an animal study that a premedica tion with antioxidizing substances will protect the an imal from the onset of experimental tumors seems to confer a role on these alterations which is not of sec ond rank [40][41][42][43][44][45][46]. Considering that both in vitro [47][48] and in vivo [35], after the administration of antioxidant drugs, an improvement of some immuno logical parameters was observed (improvement of phagocyte indexes, increase of the ratio between lym phocyte helper and suppressor), the assumption of a possible correlation between the alteration of the im munological state of the lung due to cigarette smoking and the onset of bronchogenic neoplasia does not seem to be groundless.…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte Subsets in Bronchoalveolar Lavage Fluid and in Circulating Blood in Epidermoid Bronchogenic Carcinoma

Piazza

Marchi²,

Scaglione³

et al. 1990

Respiration

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Alveolar macrophages, lymphocyte and granulocyte percentages, together with OKT3 + , OKT4+, OKT8+ lymphocyte subsets and OKT4+/OKT8+ ratio, were evaluated in bronchoalveolar lavage (BAL) fluid and in peripheral venous blood (PVB) of neoplastic and nonneoplastic subjects, in order to assess these aspects of immunity in neoplastic disease and to find out if the modifications in the bronchoalveolar environment are correlated to the ones in the circulation blood. BAL was performed in 30 patients undergoing fiberoptic bronchoscopy to ascertain the presence of lung cancer. Twelve of them had positive findings for epidermoid bronchogenic carcinoma, while in the remaining subjects the diagnosis was not confirmed. The 30 examined subjects were then grouped according to their smoking habit. In PVB, no significant difference was seen between neoplastic and nonneoplastic subjects, whereas in BAL the neoplastic patients showed a significant increase of lymphocytes OKT3 + and OKT8 + . This tends to confirm that PVB is not a good indicator of organ immunity and may justify the reduced activity of alveolar macrophages in subjects affected by bronchogenic neoplasia. Between smokers and nonsmokers, lymphocyte subsets showed more significant differences than between neoplastic and nonneoplastic subjects (decrease of T4+ lymphocytes, increase of T8+ lymphocytes and, therefore, reduction of T4/T8 ratio); there were also scalar variations in the three groups (smokers with cancer, smokers without cancer and nonsmokers without cancer). Thus, the possible autonomous role of cigarette smoke and the presence of neoplasia in the immunity alterations of the alveolar environment with final joint effects were confirmed. These data may indicate a possible correlation between cigarette smoking, immunological alterations in BAL and the onset of bronchogenic carcinoma

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