Effects of <i>Astragalus</i> Combined with <i>Angelica</i> on Bone Marrow Hematopoiesis Suppression Induced by Cyclophosphamide in Mice

Abstract

Danggui Buxue Tang (DBT), a combination of Astragalus and Angelica at a 5 : 1 ratio, mainly promotes hematopoiesis. However, in the clinic, the combination ratio of Astragalus and Angelica to treat low hematopoietic function is not an absolute 5 : 1 ratio, suggesting that the herbs may promote hematopoiesis better after being combined at a certain range of ratios. The objective of this study is to investigate the effect of different ratio combinations of Astragalus and Angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide (CTX) and to probe the interaction and mechanism of Astragalus combined with Angelica in promoting hematopoiesis. Following establishment of the model, mice were administered with Astragalus (6.00 g·kg 1

RETRACTED: Five Active Components Compatibility of Astragali Radix and Angelicae Sinensis Radix Protect Hematopoietic Function Against Cyclophosphamide-Induced Injury in Mice and t-BHP–Induced Injury in HSCs

“…A study of an aging model of HSCs induced by tert-butyl hydroperoxide (t-BHP) discovered that AR, ASR, and their compatibility could inhibit the aging of HSCs and promote HSC proliferation and cell cycle transformation. In particular, the compatibility of AR and ASR (1:1) had the strongest effect (Zhang et al, 2017) and could promote active components [FRA, FRM, AST, CAL, and CLG (calycosin-7-glucoside)] dissolution and absorption in isolated small intestine in rats (Li et al, 2017). It is suggested that the active components (FRA, FRM, AST, CAL, and CLG) may be the main effective substances of the compatibility of AR and ASR that promote hematopoiesis.…”

The therapeutic effect of modified Huangqi Guizhi Wuwu Tang for multiple myeloma

“…Studies show that Danggui Buxue Tang has inhibitory effects on bone marrow hematopoiesis suppression induced by Cyclophosphamide in mice by spurring the synthesis and secretion of hematopoietic growth factor and the proliferation of hematopoietic progenitor cells in mice. [ 42 ] It may have benefits on the patient's anemia.…”

Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination

“…Calycosin glycoside, calycosin, formononetin, and astragaloside IV are the characteristic components of Astragalus, and ferulic acid is the characteristic component of Angelica [ 7 ]. Therefore, the components were measured to identify Astragalus and Angelica by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) by our research team previously on a Waters-Xevo-G2-S QTof UPLC-MS/MS instrument (Acquity system, V4.1 Masslynx chromatography workstation, Waters Co., USA) [ 8 ]. The contents of effective components in Astragalus extract were as follows: Astragalus calycosin glycoside 462.96 μ g/g crude herb, calycosin 351.62 μ g/g crude herb, formononetin 52 μ g/g crude herb, and astragaloside 33.38 μ g/g crude herb.…”

“…The contents of the active constituents in the extract of Angelica were as follows: ferulic acid 328.74 μ g/g crude herb. The contents of effective components in the extract of Astragalus–Angelica 1:1 compatibility are ferulic acid 438.86 μ g/g crude herb, Astragalus calycosin glycoside 438.86 μ g/g crude herb, calycosin 267.82 μ g/g crude herb, formononetin 44.34 μ g/g crude herb, and astragaloside 12.46 μ g/g crude herb [ 8 ]. Studies have shown that the five chemical components can be absorbed into the plasma [ 9 ] through small intestine [ 10 ] and are related to vascular remodeling factors.…”