Effects of low power laser-irradiation on differential blood count and body temperature in endotoxin-preimmunized rabbits

Schindl, Liesbeth; Schindl, Martin; Polo, Luz; Jori, Giulio; Perl, S.; Schindl, Andreas

doi:10.1016/s0024-3205(97)00109-4

Cited by 18 publications

(11 citation statements)

References 24 publications

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“…On the basis of our data we have shown that a single irradiation of a small area of the human body surface with VIP polarized light (480–3400 nm) at a therapeutic dose (12 J/cm 2 ) leads to a 2.5‐fold increase in the intensity of spontaneous DNA synthesis in peripheral blood Lym, but only under conditions of decreased prevalues. This indicates an elevation of the proliferative Lym activity, which can be a mechanism of the repeatedly reported increase in Lym count in peripheral blood after daily irradiations both with monochromatic and polychromatic light at therapeutic doses (7,24–26). A 2.3‐ to 3‐fold increase in DNA synthetic activity in Lym of VIP‐irradiated subjects in response to a T cell mitogen, PHA, suggests that VIP light significantly enhances the T‐Lym response to an antigenic stimulus.…”

Section: Discussionmentioning

confidence: 75%

Polychromatic Light Similar to the Terrestrial Solar Spectrum Without its UV Component Stimulates DNA Synthesis in Human Peripheral Blood Lymphocytes In Vivo and In Vitro

Zhevago

Samoilova

Calderhead

2006

Photochem & Photobiology

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Immunosuppressive effects of the minor component of the terrestrial solar spectrum, UV radiation, have been substantiated over the past several years. This raises the question of what influence the dominant part of the solar spectrum--visible and IR light-would have on the human immune system. In the present randomized, placebo-controlled double-blind study a small area of the body surface of volunteers was irradiated with polychromatic light (480-3400 nm), simulating the significant part of the terrestial sunlight irradiance spectrum and its power density. An average 2.5-fold to three-fold increase in spontaneous and phytohemagglutinin-induced DNA synthesis in peripheral blood lymphocytes (Lym) was revealed at 0.5-24 h after irradiation at a therapeutic dose (12 J/cm(2)) in subjects with low preirradiation levels of both processes. The in vivo findings were echoed in parallel in vitro experiments, when blood drawn from the same subjects was directly irradiated (2.4 J/cm(2)), or when the irradiated blood was mixed 1:10 with nonirradiated autologous blood to model events in the circulation following transcutaneous blood photomodification. Our data suggest that exposure of the human body to polychromatic visible + IR light may photomodify blood in the dermal vasculature of the irradiated area to lead to an immediate transfer of the light-induced effects to Lym of the entire circulating blood, which can result in modulation of Lym functional state at the systemic level.

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Section: Discussionmentioning

confidence: 75%

Polychromatic Light Similar to the Terrestrial Solar Spectrum Without its UV Component Stimulates DNA Synthesis in Human Peripheral Blood Lymphocytes In Vivo and In Vitro

Zhevago

Samoilova

Calderhead

2006

Photochem & Photobiology

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“…In recent studies, it has been shown that LLLT affects several immunologic reactions [15][16][17]. The present study investigated whether LLLT stimulates immune cells at inflamed sites to express beta-endorphins, thereby enhancing peripheral endogenous opioid analgesia.…”

Section: Introductionmentioning

confidence: 92%

GaAlAs (830 nm) low‐level laser enhances peripheral endogenous opioid analgesia in rats

et al. 2007

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“…5 In an experimental model, the positive effect of LPL therapy was demonstrated in fracture healing. 8 Numerous effects of LPL irradiation were demonstrated in in vitro experiments, such as: (i) increase of HeLa cell-cell and cellglass adhesion; 9 (ii) protection of erythrocytes from the damage caused by a heart-lung machine; 1 0 (iii) increased recovery from the ischemic injury of hypocampal cells; 11 (iv) interference with cell cycling and different effects on cell proliferation; 1 2,13 and (v) change in phagocytic activity, viability, adherence and level of metabolic processes in the polymorphonuclear cells and monocytes. 8 Numerous effects of LPL irradiation were demonstrated in in vitro experiments, such as: (i) increase of HeLa cell-cell and cellglass adhesion; 9 (ii) protection of erythrocytes from the damage caused by a heart-lung machine; 1 0 (iii) increased recovery from the ischemic injury of hypocampal cells; 11 (iv) interference with cell cycling and different effects on cell proliferation; 1 2,13 and (v) change in phagocytic activity, viability, adherence and level of metabolic processes in the polymorphonuclear cells and monocytes.…”

Section: Introductionmentioning

confidence: 99%

Blood irradiation by He-Ne laser induces a decrease in platelet responses to physiological agonists and an increase in platelet cyclic GMP

Brill

Шенкман²,

Brill

et al. 2000

Platelets

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The effect of He-Ne laser irradiation on platelet adhesion, activation and aggregation was investigated. Citrated whole blood was irradiated in vitro by He-Ne laser (632.8 nm, 7 mW) and then subjected to shear stress (1300 s-1) on subendothelial extracellular matrix (ECM)-coated plates. Laser irradiation was followed by a decrease in platelet adhesion and aggregation on ECM under flow conditions in a time exposure-dependent manner (by 30-40%). The inhibiting effect of laser light on platelets was detectable up to 1 h after the termination of irradiation. Laser irradiation of either platelet-rich plasma, gel-filtered platelets, platelet-poor plasma, or packed blood cells followed by whole blood reconstitution revealed a marked decrease in platelet deposition on ECM only in the cases of platelet-rich plasma or gel filtered platelets. In conventional aggregometry, laser-treated platelet-rich plasma demonstrated a diminished platelet response to both thrombin receptor-activating peptide (TRAP), converting a two-wave aggregation curve to reversible, and to the protein kinase C activator PMA (by 45%). In flow cytometry analysis, irradiated platelets presented lower fibrinogen binding and P-selectin expression in response to TRAP. Laser irradiation had no additional inhibitory effect on dibutyryl cGMP- and dibutyryl cAMP-pretreated platelets. A 50% increase in cGMP level was observed in laser-treated gel filtered platelets, both in the presence and in absence of the phosphodiesterase inhibitor, isobuthylmethylxanthine. The results suggest that guanylate cyclase is one of the primary mediators of the laser effect on platelet function.

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Effects of low power laser-irradiation on differential blood count and body temperature in endotoxin-preimmunized rabbits

Cited by 18 publications

References 24 publications

Polychromatic Light Similar to the Terrestrial Solar Spectrum Without its UV Component Stimulates DNA Synthesis in Human Peripheral Blood Lymphocytes In Vivo and In Vitro

Polychromatic Light Similar to the Terrestrial Solar Spectrum Without its UV Component Stimulates DNA Synthesis in Human Peripheral Blood Lymphocytes In Vivo and In Vitro

GaAlAs (830 nm) low‐level laser enhances peripheral endogenous opioid analgesia in rats

Blood irradiation by He-Ne laser induces a decrease in platelet responses to physiological agonists and an increase in platelet cyclic GMP

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