Effects of low molecular weight soybean peptide on mRNA and protein expression levels of differentiation markers in normal human epidermal keratinocytes

Tokudome, Yoshihiro; Nakamura, Keisuke; Hashimoto, Fumie

doi:10.1080/09168451.2014.910092

Cited by 2 publications

(2 citation statements)

References 20 publications

(13 reference statements)

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“…The induction of ichthyosis vulgaris and allergen response has been reportedly associated with loss-of-function mutations in the filaggrin gene, resulting in defective barrier functioning [28,30,31]. In 2014, Tokudone et al, reported that a low molecular weight peptide originating from soybean can modulate epidermal metabolism by enhancing the gene expression of involucrin and profilaggrinin in human epidermal keratinocytes [32]. Soybean trypsin inhibitor (STI) and Bowman-Birk protein inhibitor (BBI) were first isolated from soybean in the early 1940s.…”

Section: Soybean Peptidesmentioning

confidence: 99%

Review of Soybean Phytochemicals and Their Bioactive Properties Relevant for Skin Health

Kim¹,

Kang²,

Park³

et al. 2017

JFNR

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Numerous studies have investigated the bioactive properties of compounds present in soybean (Glycine max) that may have beneficial effects on the health of human skin. Several such compounds have already been introduced into commercial cosmetic products to promote functional properties such as skin whitening, anti-wrinkle activity and skin hydration. However, a significantly greater understanding of the application of soybean ingredients in these types of products is needed before optimal benefits can be realized. In this review, we aim to summarize some of the biological properties of soybean constituents and the underlying mechanisms of action responsible for beneficial effects in skin. In addition, we will discuss future directions for studies that may help to expand the applications for soybean compounds.

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Section: Soybean Peptidesmentioning

confidence: 99%

Review of Soybean Phytochemicals and Their Bioactive Properties Relevant for Skin Health

Kim¹,

Kang²,

Park³

et al. 2017

JFNR

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“…Some of these peptides exert numerous beneficial effects, such as antidiabetic, anticancer, hypotensive, anti-inflammatory, and radical scavenging effects, in various experimental models. Soybean peptides have an average molecular weight of approximately 3-10 kDa and high glutamic acid content [4]. Enzymes, bacteria, and types of soy protein affect the composition and production of peptides [5].…”

Section: Introductionmentioning

confidence: 99%

The Radical Scavenging Activities and Anti-Wrinkle Effects of Soymilk Fractions Fermented with Lacticaseibacillus paracasei MK1 and Their Derived Peptides

Lee¹,

Choi²,

Jeong

et al. 2023

Antioxidants

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Soybean-derived peptides exert several beneficial effects in various experimental models. However, only a few studies have focused on the radical scavenging and anti-wrinkle effects of soymilk-derived peptides produced via different processes, such as fermentation, enzymatic treatment, and ultrafiltration. Therefore, in this study, we investigated the radical scavenging and antiwrinkle effects of soymilk fractions produced using these processes. We found that 50SFMKUF5, a 5 kDa ultrafiltration fraction fermented with Lacticaseibacillus paracasei MK1 after flavourzyme treatment, exhibited the highest radical scavenging activity using the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay as well as potent anti-wrinkle effects assessed by type 1 procollagen production and tumor necrosis factor-α production in ultraviolet B (UVB)-treated human dermal fibroblasts and HaCaT keratinocytes. To identify potential bioactive peptides, candidate peptides were synthesized, and their anti-wrinkle effects were assessed. APEFLKEAFGVN (APE), palmitoyl-APE, and QIVTVEGGLSVISPK peptides were synthesized and used to treat UVB-irradiated fibroblasts, HaCaT keratinocytes, and α-melanocyte-stimulating hormone-induced B16F1 melanoma cells. Among these peptides, Pal-APE exerted the strongest effect. Our results highlight the potential of soymilk peptides as anti-aging substances.

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Effects of low molecular weight soybean peptide on mRNA and protein expression levels of differentiation markers in normal human epidermal keratinocytes

Cited by 2 publications

References 20 publications

Review of Soybean Phytochemicals and Their Bioactive Properties Relevant for Skin Health

Review of Soybean Phytochemicals and Their Bioactive Properties Relevant for Skin Health

The Radical Scavenging Activities and Anti-Wrinkle Effects of Soymilk Fractions Fermented with Lacticaseibacillus paracasei MK1 and Their Derived Peptides

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