Effects of low-level lead exposure on pyrimidine 5'-nucleotidase and other erythrocyte enzymes. Possible role of pyrimidine 5'-nucleotidase in the pathogenesis of lead-induced anemia.

Paglia, Donald E.; Valentine, William N.; Dahlgren, James

doi:10.1172/jci108192

Cited by 125 publications

(49 citation statements)

References 27 publications

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“…Lead bioaccumulation caused essential reduction of the percentage normal erythrocytes and respectively significant increase of the percentage pathological erythrocytes in the peripheral blood [95]. This finding confirms the study of [94] that has been shown that Pb causes morphological changes in erythropoietic bone marrow cells, leading to production of microcytic and hypochromic erythrocytes.…”

Section: Lead -Toxic Effects On Animals and Humanssupporting

confidence: 90%

Zeolites versus Lead Toxicity

R¹

2015

J Bioequiv Availab

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Section: Lead -Toxic Effects On Animals and Humanssupporting

confidence: 90%

Zeolites versus Lead Toxicity

R¹

2015

J Bioequiv Availab

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“…This has been reported in lead workers, with the greatest inhibition and marked accumulations of pyrimidine nucleotides apparent in workers with overt intoxication, including anemia (Paglia et al 1975(Paglia et al , 1977. PbBs in these workers ranged between 45 and 110 μg/dL, and 7 of 9 were anemic.…”

Section: Health Effectsmentioning

confidence: 69%

Characterizing Golden Eagle Risk to Lead and Anticoagulant Rodenticide Exposure: A Review

Herring

Eagles‐Smith

Buck

2017

Journal of Raptor Research

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“…A lead-induced deficiency of P5N-I also results in the induction of basophilic stippling and premature erythrocyte hemolysis analogous to that encountered in genetically induced enzyme-deficiency syndrome [17,18,22]. Treatment of erythrocytes with lead also inhibits canine P5N-I [8], resulting in retardation of the morphological reticulocyte maturation [7].…”

Section: Discussionmentioning

confidence: 95%

Inhibitory Effect of Pyrimidine and Purine Nucleotides on the Multiplication of <i>Babesia gibsoni</i>: Possible Cause of Low Parasitemia and Simultaneous Reticulocytosis in Canine Babesiosis

Hossain

Yamato

Yamasaki

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. The present study was conducted to determine the cause of low parasitemia and simultaneous reticulocytosis in canine babesiosis. The parasitemia was significantly decreased in in vitro cultures of Babesia gibsoni by the pretreatment of host canine erythrocytes with lead acetate, which is a specific inhibitor of pyrimidine 5'-nucleotidase subclass I (P5N-I). The serum from dogs chronically infected with B. gibsoni did not decrease the activities of hexokinase, glucose-6-phosphate dehydrogenase or 6-phosphogluconate dehydrogenase in canine reticulocytes, although it was previously reported that this serum had inhibitory effects on both the maturation of reticulocytes and the canine P5N-I and purine-specific 5'-nucleotidase activities. Furthermore, the in vitro multiplication of B. gibsoni was significantly inhibited by pyrimidine nucleotides such as cytidine 5'-monophosphate (5'-CMP), which is preferentially catalyzed by P5N-I and also inhibits the morphological maturation of canine reticulocytes. Purine nucleotides such as inosine 5'-monophospha te (5'-IMP) also had an inhibitory effect on the multiplication of this parasite. These results suggest that nucleotides such as 5'-CMP and 5'-IMP might accumulate in young erythrocytes and/or serum in dogs infected with B. gibsoni as a result of the decreased activity of erythrocyte 5'-nucleotidase, and the accumulation of these nucleotides might inhibit the multiplication of this parasite and simultaneously retard the maturation of reticulocytes. The results obtained from the in vitro examinations in the present study may partially clarify the relationship between low parasitemia and simultaneous reticulocytosis in vivo in canine babesiosis. KEY WORDS: Babesia gibsoni, erythrocyte 5'-nucleotidase, purine nucleotide, pyrimidine nucleotide, reticulocyte.

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Effects of low-level lead exposure on pyrimidine 5'-nucleotidase and other erythrocyte enzymes. Possible role of pyrimidine 5'-nucleotidase in the pathogenesis of lead-induced anemia.

Cited by 125 publications

References 27 publications

Zeolites versus Lead Toxicity

Zeolites versus Lead Toxicity

Characterizing Golden Eagle Risk to Lead and Anticoagulant Rodenticide Exposure: A Review

Inhibitory Effect of Pyrimidine and Purine Nucleotides on the Multiplication of <i>Babesia gibsoni</i>: Possible Cause of Low Parasitemia and Simultaneous Reticulocytosis in Canine Babesiosis

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