Effects of Low Level Lead ingestion in Sheep

Tl, Carson; Ga, Van Gelder; Wb, Buck; Lj, Hoffman; Dl, Mick; Kr, Long

doi:10.3109/15563657308990539

Cited by 16 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the first part of the experiment, 6, 8, and 6 lambs from ewes which had re-ceived 0 (control), 2.3 (low), or 4.5 (high) mg lead/kg-day, respectively, throughout gestation were tested in the maze (14). Mean blood residues in the ewes during pregnancy were 5, 18, and 34 uag/100 ml for the control, low, and high groups, respectively.…”

mentioning

confidence: 99%

Development of Behavioral Tests for the Assessment of Neurologic Effects of Lead in Sheep

Carson¹,

Gelder²,

Karas³

et al. 1974

Environmental Health Perspectives

Self Cite

View full text Add to dashboard Cite

Reports of neurologic impairment of children following recovery from acute lead encephalopathy have raised questions concerning the effects of chronic low-level lead exposure on the central nervous system. Behavioral toxicologic techniques have been employed to assess the effects of lead on the central nervous system in sheep. Mature sheep receiving daily doses of 100 mg lead/kg showed a significant decrease in performance on an auditory signal detection task. Daily oral doses of 120 and 230 mg lead/sheep for 27 weeks did not alter the performance of mature sheep on a fixed-interval schedule of reinforcement behavioral task. Prenatal exposure to maternal blood lead levels of 16 or 34 mug/100 ml during gestation and postnatal daily ingestion of 16, 8, 4, or 2 mg lead/kg did not alter performance of lambs on a closed-field maze task. Slowed learning was demonstrated in lambs prenatally exposed to maternal blood lead levels of 34 mug/100 ml during gestation when tested on nonspatial, two-choice visual discrimination problems at 10-15 months of age.

show abstract

mentioning

confidence: 99%