Effects of low-level combined static and weak low-frequency alternating magnetic fields on cytokine production and tumor development in mice

Новоселова, Е. Г.; Novikov, V. V.; Лунин, С. М.; Глушкова, О. В.; Новоселова, Т. В.; Parfenyuk, Svetlana B.; Novoselov, Sergey V.; Хренов, М. О.; Фесенко, Е. Е.

doi:10.1080/15368378.2018.1545667

Cited by 13 publications

(21 citation statements)

References 42 publications

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“…In addition, Chen et al (2010) found that the static magnetic fields enhanced the potency of cisplatin on K562 cells, resulting in DNA damage [53]. The same findings were observed in vivo by others, where tumours' growth suppression in mice was demonstrated [19,20].…”

Section: Ros and Intracellular Ca 2+ Changes Generated By Rotating Magnetic Field-cell Type Mattersmentioning

confidence: 58%

Modulation of Cellular Response to Different Parameters of the Rotating Magnetic Field (RMF)—An In Vitro Wound Healing Study

Jedrzejczak-Silicka,

Kordas,

Konopacki

et al. 2021

IJMS

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Since the effect of MFs (magnetic fields) on various biological systems has been studied, different results have been obtained from an insignificant effect of weak MFs on the disruption of the circadian clock system. On the other hand, magnetic fields, electromagnetic fields, or electric fields are used in medicine. The presented study was conducted to determine whether a low-frequency RMF (rotating magnetic field) with different field parameters could evoke the cellular response in vitro and is possible to modulate the cellular response. The cellular metabolic activity, ROS and Ca2+ concentration levels, wound healing assay, and gene expression analyses were conducted to evaluate the effect of RMF. It was shown that different values of magnetic induction (B) and frequency (f) of RMF evoke a different response of cells, e.g., increase in the general metabolic activity may be associated with the increasing of ROS levels. The lower intracellular Ca2+ concentration (for 50 Hz) evoked the inability of cells to wound closure. It can be stated that the subtle balance in the ROS level is crucial in the wound for the effective healing process, and it is possible to modulate the cellular response to the RMF in the context of an in vitro wound healing.

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Section: Ros and Intracellular Ca 2+ Changes Generated By Rotating Magnetic Field-cell Type Mattersmentioning

confidence: 58%

Modulation of Cellular Response to Different Parameters of the Rotating Magnetic Field (RMF)—An In Vitro Wound Healing Study

Jedrzejczak-Silicka,

Kordas,

Konopacki

et al. 2021

IJMS

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“…Meanwhile, the MF exposure was associated with the activation of macrophages and dendritic cells, enhancement of the profiles of CD4+T and CD8+T lymphocytes, the balance of Th17/Treg, and the reduction of the inhibitory function of Treg cells in vivo (82). A combination of SMF with AMF stimulated the production of tumor necrosis factor-α (TNF-α), interferon-gamma, IL-2, and IL-3 in healthy mouse cells, inhibited solid tumor growth, and enhanced the average lifespan, after daily exposure for 2 h within 14 days (83).…”

Section: The Effects Of Mfs On the Immune Systemmentioning

confidence: 99%

Progressive Study on the Non-thermal Effects of Magnetic Field Therapy in Oncology

Wang

et al. 2021

Front. Oncol.

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Cancer is one of the most common causes of death worldwide. Although the existing therapies have made great progress and significantly improved the prognosis of patients, it is undeniable that these treatment measures still cause some serious side effects. In this context, a new treatment method is needed to address these shortcomings. In recent years, the magnetic fields have been proposed as a novel treatment method with the advantages of less side effects, high efficiency, wide applications, and low costs without forming scars. Previous studies reported that static magnetic fields (SMFs) and low-frequency magnetic fields (LF-MFs, frequency below 300 Hz) exert anti-tumor function, independent of thermal effects. Magnetic fields (MFs) could inhibit cell growth and proliferation; induce cell cycle arrest, apoptosis, autophagy, and differentiation; regulate the immune system; and suppress angiogenesis and metastasis via various signaling pathways. In addition, they are effective in combination therapies: MFs not only promote the absorption of chemotherapy drugs by producing small holes on the surface of cell membrane but also enhance the inhibitory effects by regulating apoptosis and cell cycle related proteins. At present, MFs can be used as drug delivery systems to target magnetic nanoparticles (MNPs) to tumors. This review aims to summarize and analyze the current knowledge of the pre-clinical studies of anti-tumor effects and their underlying mechanisms and discuss the prospects of the application of MF therapy in cancer prevention and treatment.

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“…We summarize the reactions of both the innate and the adaptive immune cells to different types of MFs in Table 1. Generally, upon exposure to a very low-frequency AMF (50-75 Hz, 0.8-7 mT), the innate immune cells get more activated and initiate the inflammatory responses in mice and rats (9,(16)(17)(18)(19)(20)(21). Natural killer cells (NK cells) are found to be more cytotoxic under 0.4 T SMF Abbreviations: AMF, alternating magnetic fields; DC, dendritic cell; EMF, electromagnetic field; FTH, heavy chain H-ferritin; FPN1, ferroportin-1; GPX4, glutathione peroxidase; HGMF, high-gradient magnetic field; HO-1, heme oxygenase-1; MDSC, myeloid-derived suppressor cell; MF, magnetic field; MRI, magnetic resonance imaging; NK cell, natural killer cell; NP, nanoparticle; OC, osteoclast; ROS, reactive oxygen species; SMF, static magnetic field; TCR, T-cell receptor; TfR1, transferrin receptor-1.…”

Section: Immune Reactions Under Various Types Of Mfsmentioning

confidence: 99%

Innate Immune Regulation Under Magnetic Fields With Possible Mechanisms and Therapeutic Applications

Lei

Pan

et al. 2020

Front. Immunol.

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With the wide applications of magnetic fields (MFs) in medicine, researchers from different disciplines have gained interest in understanding the effect of various types of MFs on living cells and organisms. In this paper, we mainly focus on the immunological and physical aspects of the immune responses and their mechanisms under different types of MFs. Immune cells were slightly affected by low-frequency alternating MFs but were strongly influenced by moderate-intensity MFs and high-gradient MFs (HGMFs). Larger immune cells, such as macrophages, were more sensitive to HGMFs, which biased the cell polarization into the anti-inflammatory M2 phenotype. Subject to the gradient forces of varying directions and strength, the elongated M2 macrophage also remodeled the cytoskeleton with actin polymerization and changed the membrane receptors and ion channel gating. These alterations were very similar to changes caused by the small GTPase RhoA interference in macrophage. Regulation of iron metabolism may also contribute to the MF effects in macrophages. High MFs were found to regulate the iron content in monocyte-/macrophage-derived osteoclasts by affecting the expression of iron-regulation genes. On the other hand, paramagnetic nanoparticles (NPs) combined with external MFs play an important role in T-cell immunity. Paramagnetic NP-coated Tcells can cluster their T-cell receptors (TCRs) by using an external MF, thus increasing the cell-cell contact and communication followed by enhanced tumor killing capacity. The external MF can also guide the adoptively transferred magnetic NP-coated T-cells to their target sites in vivo, thus dramatically increasing the efficiency of cell therapy. Additionally, iron oxide NPs for ferroptosis-based cancer therapy and other MF-related therapeutic applications with obstacles were also addressed. Furthermore, for a profound understanding of the effect of MFs on immune cells, multidisciplinary research involving both experimental research and theoretical modeling is essential.

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Effects of low-level combined static and weak low-frequency alternating magnetic fields on cytokine production and tumor development in mice

Cited by 13 publications

References 42 publications

Modulation of Cellular Response to Different Parameters of the Rotating Magnetic Field (RMF)—An In Vitro Wound Healing Study

Modulation of Cellular Response to Different Parameters of the Rotating Magnetic Field (RMF)—An In Vitro Wound Healing Study

Progressive Study on the Non-thermal Effects of Magnetic Field Therapy in Oncology

Innate Immune Regulation Under Magnetic Fields With Possible Mechanisms and Therapeutic Applications

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