Effects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis

Preud'homme, Valérie; Milla, Sylvain; Gillardin, Virginie; Pauw, Edwin De; Denoël, Mathieu; Kestemont, Patrick

doi:10.1016/j.chemosphere.2014.07.096

Cited by 19 publications

(2 citation statements)

References 49 publications

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“…In rats, the mechanism responsible for AChE activation may be induced by adrenaline through the induction of guanylate and adenylate cyclases [80]. These findings are in agreement with several results from other papers evaluating the impact of insecticides on neurobehavioral performance in the animal model [81,82].…”

Section: Discussionsupporting

confidence: 88%

Deltamethrin and Its Nanoformulations Induce Behavioral Alteration and Toxicity in Rat Brain through Oxidative Stress and JAK2/STAT3 Signaling Pathway

Khalifa

Moselhy

Mohammed

et al. 2022

Toxics

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Deltamethrin (DM) is the most powerful synthetic pyrethroid that has toxicity to the central nervous system and results in behavioral changes in both animals and humans. This effect is mediated by inducing alterations in the action of neurotransmitters and brain pathological changes. Nanocarrier encapsulated pesticides may decrease the toxicity of pesticides. Thus, this study aimed to determine the effect of an inorganic metal carrier (silica Nps) and polymeric capsule (chitosan Nps) of deltamethrin nano-formulations on antioxidant levels and oxidative stress in the brain and on behavior of the male albino rat. Sixty male albino rats were equally divided into four groups. Group I: control group; group II given DM liquefied in corn oil at 3.855 mg/kg BW; group III receiving silica-loaded deltamethrin (S/DM Nps) at 8.795 mg/kg BW; and group IV: given chitosan encapsulated deltamethrin (CS/DM Nps) at 30.44 mg/kg BW. All treatments were given orally for four weeks. Following this, behavioral tests were conducted to record locomotor activity, anxiety like behaviors, exploration, and the short memory of rats. In addition, brain antioxidant/oxidant, serum neurotransmitters such as acetylcholine esterase (AchE) and monoamine oxidase (MAO), JAK2 and STAT3 gene and proteins expression were measured. The DM group showed a highly significant elevation in malondialdehyde content, MAO, AchE, vascular endothelial growth factor (VEGF) levels, and the expression level of neurogenic genes, JAK2 and STAT3, in comparison with the control group. Both S/DM Nps and CS/DM Nps significantly decreased MAO, AchE, and VEGF compared with the DM group. Moreover, both S/DM Nps and CS/DM Nps significantly decreased the gene and proteins expression of JAK2 and STAT3 compared with the DM group. These alterations were evidenced by the deficiency in memory and learning behaviors that were accompanied by histopathological findings of the hippocampus and the cortex. It was concluded that the nano formulations containing DM induced less neurobehavioral toxicity than free DM. Additionally, the use of nanocarriers reduced the damage to health and the environment.

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Section: Discussionsupporting

confidence: 88%

Deltamethrin and Its Nanoformulations Induce Behavioral Alteration and Toxicity in Rat Brain through Oxidative Stress and JAK2/STAT3 Signaling Pathway

Khalifa

Moselhy

Mohammed

et al. 2022

Toxics

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show abstract

“…Regarding endosulfan, initial reports indicated that this pesticide is "very plant tolerant", producing little damage to the plants and having little effect on mineral tissue composition and yields of different crops [52]. However, more recent studies revealed its high phytotoxic effects, even at lower concentrations, on seed germination, plant growth, and nutrients uptake [53][54][55][56][57], and its adverse effects on soil and water biota [58][59][60][61] and human health [14,62]. In the present study, the deleterious effects of the pesticide were most clearly shown by the substantial inhibition of seed germination.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Pesticide Endosulfan and Two Different Biostimulants on the Stress Responses of Phaseolus leptostachyus Plants Grown in a Saline Soil

et al. 2021

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Soil salinity and the indiscriminate use of agrochemicals has significantly reduced the productivity of the ‘Chinampas’ agroecosystem in Mexico City. Crop improvement under these stressful conditions may be achieved by soil bioremediation. In this study, we checked the effects of the organochlorine pesticide endosulfan and bioremediation with Penicillium crustosum or a citric waste on the growth of Phaseolus leptostachyus plants in saline soil from the Chinampas area. Biochemical markers associated with specific stress responses were also determined after one month of growth in the different substrates. Plant growth was stimulated by bioremediation of the soil. Both biostimulants reduced the degree of stress affecting the plants, as shown by the increase in photosynthetic pigments and the reduction of proline, malondialdehyde (MDA), and H2O2 contents, and the activation of antioxidant systems. However, the biostimulants appeared to mitigate oxidative stress through different mechanisms. Endosulfan contamination inhibited seed germination—which was reverted to control values in the presence of the biostimulants—and further decreased plant growth. No clear patterns of variation of biochemical stress markers were observed combining endosulfan and the biostimulants. In any case, bioremediation with P. crustosum and/or citric waste is recommended to improve the germination and growth of P. leptostachyus plants.

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Effect of Lead Exposure on Jumping Ability in Pelophylax nigromaculata

Duan

Huang

et al. 2021

Bull Environ Contam Toxicol

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Effects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis

Cited by 19 publications

References 49 publications

Deltamethrin and Its Nanoformulations Induce Behavioral Alteration and Toxicity in Rat Brain through Oxidative Stress and JAK2/STAT3 Signaling Pathway

Deltamethrin and Its Nanoformulations Induce Behavioral Alteration and Toxicity in Rat Brain through Oxidative Stress and JAK2/STAT3 Signaling Pathway

Effect of the Pesticide Endosulfan and Two Different Biostimulants on the Stress Responses of Phaseolus leptostachyus Plants Grown in a Saline Soil

Effect of Lead Exposure on Jumping Ability in Pelophylax nigromaculata

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