Effects of low and high molecular weight hyaluronic acid on the osteoarthritic temporomandibular joint in rabbit

Iturriaga, Verónica; Vásquez, Bélgica; Bornhardt, Thomas; Sol, Mariano del

doi:10.1007/s00784-020-03763-x

Cited by 23 publications

(31 citation statements)

References 47 publications

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“…High-molecular-weight HA (HMW HA), which is more than 1000 kDa, contributes to the viscoelasticity of the synovial fluid [ 20 ]. Iturriaga et al [ 24 ] distinguished three different categories of the exogenous HA preparations regarding their molecular weight, namely low-molecular-weight HA (LMW HA) 500–1000 kDa, medium-molecular-weight (MMW HA) 1200–4500 kDa and HMW HA 6000–7000 kDa. HMW HA presents an anti-inflammatory effect [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…Lemos et al [ 35 ] concluded that HMW HA may have a positive impact on osteoarthritic TMJs, because in individuals treated with HMW HA, the authors observed, among others, limited histologic changes, lower activity of metalloproteinases (MMP-2 and MMP-9), as well as a greater arrangement of collagenous fibers. Contrary to the previously mentioned studies, Iturriaga et al [ 24 ] compared the efficacy of LMW HA and HMW HA intraarticular injections in the treatment of TMJ OA. The authors noticed that better results regarding the repairing processes of the cartilage and the articular disc were obtained with the usage of the LMW HA.…”

Section: Resultsmentioning

confidence: 99%

“…The authors noticed that better results regarding the repairing processes of the cartilage and the articular disc were obtained with the usage of the LMW HA. Although the results presented by the above-listed authors [ 24 , 33 , 34 , 35 ] seem very promising, it must be emphasized that all of these studies were performed on different animal models, namely rats [ 33 , 35 ] and rabbits [ 24 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

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Mechanisms of Action and Efficacy of Hyaluronic Acid, Corticosteroids and Platelet-Rich Plasma in the Treatment of Temporomandibular Joint Osteoarthritis—A Systematic Review

Derwich¹,

Mituś-Kenig

Pawłowska

2021

IJMS

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Temporomandibular joint osteoarthritis (TMJ OA) is a low-inflammatory disorder with multifactorial etiology. The aim of this review was to present the current state of knowledge regarding the mechanisms of action and the efficacy of hyaluronic acid (HA), corticosteroids (CS) and platelet-rich plasma (PRP) in the treatment of TMJ OA.: The PubMed database was analyzed with the keywords: “(temporomandibular joint) AND ((osteoarthritis) OR (dysfunction) OR (disorders) OR (pain)) AND ((treatment) OR (arthrocentesis) OR (arthroscopy) OR (injection)) AND ((hyaluronic acid) OR (corticosteroid) OR (platelet rich plasma))”. After screening of 363 results, 16 studies were included in this review. Arthrocentesis alone effectively reduces pain and improves jaw function in patients diagnosed with TMJ OA. Additional injections of HA, either low-molecular-weight (LMW) HA or high-molecular-weight (HMW) HA, or CS at the end of the arthrocentesis do not improve the final clinical outcomes. CS present several negative effects on the articular cartilage. Results related to additional PRP injections are not consistent and are rather questionable. Further studies should be multicenter, based on a larger group of patients and should answer the question of whether other methods of TMJ OA treatment are more beneficial for the patients than simple arthrocentesis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Mechanisms of Action and Efficacy of Hyaluronic Acid, Corticosteroids and Platelet-Rich Plasma in the Treatment of Temporomandibular Joint Osteoarthritis—A Systematic Review

Derwich¹,

Mituś-Kenig

Pawłowska

2021

IJMS

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“…Fourthly, strati cation of drug (e.g. low and high molecular weight (LMW / HMW) HA) (36) was insu cient in the RCTs included, which may bring confounding factors to our NMA.…”

Section: Disccusionmentioning

confidence: 99%

No Effects of Intra-Articular Injections of Sodium Hyaluronate, Corticosteroids, Platelet-Rich Plasma on Temporomandibular Joint Osteoarthritis: a Systematic Review and Network Meta-analysis of Randomized Controlled Trials

Zhao

Yao

et al. 2021

Preprint

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Background Intra-articular injections of corticosteroids (CCS), hyaluronic acid (HA), and platelet-rich plasma (PRP) have often been used for temporomandibular joint osteoarthritis (TMJ OA). However, there is no guideline for the choice of pharmacological injections. The aim of this network meta-analysis (NMA) is to compare the efficacy of different intra-articular injectable treatments on TMJ OA. Methods Studies were identified from PubMed, Embase and Cochrane Central with date up to December 2020. Randomized Controlled Trials (RCTs) included were the studies of patients with TMJ OA who had intra-articular treatment with CCS, HA, PRP, placebo and follow-up assessing TMJ function in target outcome variables. The primary outcome was temporomandibular joint pain (VAS). The secondary outcomes were maximal mouth opening (mm), and lateral movement to the affected side (mm). Results Nine RCTs involving 316 patients were included. For primary pain outcome, no significance was detected when CCS, HA and PRP were compared with placebo by both short- (3-6 months) and long-term (>12 months) follow-up. In addition, these injectables did not significantly outperform placebo by evaluating secondary functional outcomes (maximal mouth opening and lateral movement) with the same follow-up. Subgroup analyses showed that the effect of CCS on subgroups with more than 70% women was statistically less effective compared with placebo. Conclusion Evidence suggested that intra-articular pharmacological injections of CCS, HA, and PRP had no effect on improving TMJ pain and functional outcomes compared with placebo injection. Trial registration This study is registered with PROSPERO, number CRD42021270914.

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“…Было продемонстрировано восстановление хряща и суставного диска через 30 дней, при этом препараты со средней молекулярной массой оказывали лучшее воздействие на суставную ткань, чем препараты с высокой молекулярной массой. Однако через 135 дней в обеих группах наблюдался регресс восстановления суставной ткани, что подтверждает необходимость регулярных курсов терапии для сохранения полученного эффекта [33].…”

Section: препараты с различной молекулярной массой гкunclassified

Intra-articular hyaluronic acid: dependence of the effect on molecular weight

Filatova¹,

Gawert²

2021

Russian Medical Inquiry

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The article discusses the patient management with knee osteoarthritis according to the ESCEO 2019 algorithm. The focus is on the second stage in the persistence of osteoarthritis signs. The article pays attention to the means based on hyaluronic acid for intra-articular injection. It also provides the study analysis that proved the anti-inflammatory mechanism of action of hyaluronic acid-based drugs during intraarticular administration, as well as the study results in which histology data indicated that hyaluronic acid prevents cartilage degradation and can promote its regeneration. These researches show that repeated injections of hyaluronic acid are not only effective, but also safe. In the literature, there is evidence that during treatment, the time to endoprosthesis increases, as well as the need for taking NSAIDs and opioids decreases. The article discusses the molecular weight of hyaluronic acid, providing research data confirming the greatest efficacy of hyaluronic acid with medium and high molecular weight. KEYWORDS: osteoarthritis, knee joints, hyaluronic acid, intraarticular injection. FOR CITATION: Filatova Yu.S., Gawert V.R. Intra-articular hyaluronic acid: dependence of the effect on molecular weight. Russian Medical Inquiry. 2021;5(3):156–161. DOI: 10.32364/2587-6821-2021-5-3-156-161.

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Effects of low and high molecular weight hyaluronic acid on the osteoarthritic temporomandibular joint in rabbit

Cited by 23 publications

References 47 publications

Mechanisms of Action and Efficacy of Hyaluronic Acid, Corticosteroids and Platelet-Rich Plasma in the Treatment of Temporomandibular Joint Osteoarthritis—A Systematic Review

Mechanisms of Action and Efficacy of Hyaluronic Acid, Corticosteroids and Platelet-Rich Plasma in the Treatment of Temporomandibular Joint Osteoarthritis—A Systematic Review

No Effects of Intra-Articular Injections of Sodium Hyaluronate, Corticosteroids, Platelet-Rich Plasma on Temporomandibular Joint Osteoarthritis: a Systematic Review and Network Meta-analysis of Randomized Controlled Trials

Intra-articular hyaluronic acid: dependence of the effect on molecular weight

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