Intra-articular hyaluronic acid: dependence of the effect on molecular weight

Filatova, Yu.S.; Gawert, V.R.

doi:10.32364/2587-6821-2021-5-3-156-161

Russian Medical Inquiry

2021

DOI: 10.32364/2587-6821-2021-5-3-156-161

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Intra-articular hyaluronic acid: dependence of the effect on molecular weight

Yu.S. Filatova¹,

V.R. Gawert²

Abstract: The article discusses the patient management with knee osteoarthritis according to the ESCEO 2019 algorithm. The focus is on the second stage in the persistence of osteoarthritis signs. The article pays attention to the means based on hyaluronic acid for intra-articular injection. It also provides the study analysis that proved the anti-inflammatory mechanism of action of hyaluronic acid-based drugs during intraarticular administration, as well as the study results in which histology data indicated that hyalur… Show more

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Cited by 3 publications

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Comparative effectiveness of intra-articular administration of different drugs of hyaluronic acid with various physico-chemical properties in knee osteoarthritis

Belyaeva

Fatenko

Авдеева

et al. 2021

Sovremennaâ revmatologiâ

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Knee osteoarthritis (KOA) is a chronic disease that leads to a significant deterioration in the quality of life and disability. In the treatment of OA, hyaluronic acid (HA) drugs have an important place.Objective: to compare the effectiveness of ROA treatment with different HA drugs with different physicochemical properties and molecular weight.Patients and methods. A 12-week prospective randomized study of the comparative efficacy of a single intra-articular injection of three HA drugs – Armaviscon Forte (AF), Flexotron Cross (FCr) and Flexotron Ultra (FUL) was carried out. The study group consisted of 90 patients with knee osteoarthritis, aged from 43 to 50 years (the majority were women – 63.3%) with an initial severity of pain >40 mm according to the visual analogue scale (VAS). The result of therapy was assessed by the dynamics of pain (VAS), WOMAC index, and subjective assessment of the effect 3 months after intra-articular administration of HA.Results and discussion. Eight patients dropped out of the study: in the AF group – 3, FCr – 4, FUL – 1. After 90 days, the decrease in pain compared to baseline values in the AF group was 30%, in FCr – 46% and in FUL – 57% (p ≤0,05), and the dynamics of the WOMAC index – 27, 36, and 42%, respectively. After 90 days, 85.0, 93.4 and 96.5% of patients noted improvement and significant improvement in the AF, FCr and FUL groups, respectively. No serious adverse events were recorded.Conclusion. All investigated drugs demonstrated high analgesic potential, but the best clinical effect was observed with FUL.

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Comparative effectiveness of intra-articular administration of different drugs of hyaluronic acid with various physico-chemical properties in knee osteoarthritis

Belyaeva

Fatenko

Авдеева

et al. 2021

Sovremennaâ revmatologiâ

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Osteoarthritis of the hip joints: possibilities of local therapy

Filatova,

Solovyov,

Gruzdev

2023

Medicinskij sovet

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Osteoarthritis of the hip joints is one of the most common pathology of the musculoskeletal system. The issues of its therapy are discussed in all clinical recommendations and recently more and more attention has been paid to the introduction of hyaluronic acid preparations. In the Russian recommendations for the treatment of coxarthrosis, this recommendation has a high level of credibility and evidence and is based on a significant number of studies confirming the safety and effectiveness of this therapy in the long term. The article provides data from some studies, as well as the conclusions of the European Consensus Group on intra-articular administration of hyaluronic acid, which prescribes indications and contraindications for the introduction of drugs into the hip joints. The issue of choosing a specific drug among a variety of forms is also discussed and a clinical example of the administration of hyaluronic acid to a patient with osteoarthritis of the hip joints under ultrasound control is considered. A detailed technique of drug administration is described. When considering this clinical example, the good tolerability of the drug, the accuracy of the administration of the drug, as well as the long-term results of the safety and effectiveness of therapy in the form of pain reduction and the absence of the need for NSAIDs are demonstrated.

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Application of Hyaluronic Acid Preparations in Orthopedics and Dentistry

Yarikov,

Rumyantseva,

Khudoshin

et al. 2024

Bulletin of Science and Practice

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The article is a comparative analysis of hyaluronic acid preparations widely used in clinical practice. An analysis of modern literature on the use of “synovial fluid prostheses” for patients with osteoarthritis is presented. The advantages of using intra-articular injections of hyaluronic acid preparations are shown. According to indications and in compliance with technical conditions the use of products containing hyaluronic acid and its salts for intra-articular injections can improve the functional state of the joints. The article also describes the use of hyaluronic acid in dentistry for diseases of the temporomandibular joint, inflammatory diseases of the oral cavity, including diseases of periodontal tissue, tooth extraction, osteotomies, etc.

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Intra-articular hyaluronic acid: dependence of the effect on molecular weight

Cited by 3 publications

References 33 publications

Comparative effectiveness of intra-articular administration of different drugs of hyaluronic acid with various physico-chemical properties in knee osteoarthritis

Comparative effectiveness of intra-articular administration of different drugs of hyaluronic acid with various physico-chemical properties in knee osteoarthritis

Osteoarthritis of the hip joints: possibilities of local therapy

Application of Hyaluronic Acid Preparations in Orthopedics and Dentistry

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