Effects of lorazepam on rate of forgetting, on retrieval from semantic memory and on manual dexterity

Brown, John L.; Brown, Malcolm W.; Bowes, John E.

doi:10.1016/0028-3932(83)90006-4

Cited by 48 publications

(20 citation statements)

References 15 publications

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“…The massive impairment found with variable cue locations is consistent with the proposal that BZs affect attentional processes that are stressed by factors such as unpredictability which increase stimulus complexity. This would also be in agreement with the human evidence (Brown et al 1983) that BZs disrupt encoding but not short-term memory storage.…”

Section: Discussionsupporting

confidence: 80%

Effects of chlordiazepoxide on cued radial maze performance in rats

Hodges

Green

1986

Psychopharmacology

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Effects of chlordiazepoxide (CDP) were examined on the performance of rats in an eight-arm radial maze with four cued and food-baited arms. Two conditions were used; random, with cue location varying over trials, and constant, with the same subset of arms consistently cued. In rats pre-trained to a 60-70% efficiency level (Rewarded entries/Total entries X 100), the effects of CDP (2.5, 5.0 and 10.0 mg/kg, IP) differed according to condition. Efficiency was substantially reduced in the random condition, and types of error were undifferentiated. In the constant cue condition the post-drug drop in efficiency was less marked, and errors were selectively those of re-entry into rewarded arms. In both conditions there was a high incidence of error clusters involving re-entries into both rewarded and non-rewarded arms in the random condition, and rewarded arms in the constant condition. The results suggested that CDP induced a general disruption of information processing rather than a specific impairment of working memory, together with some response perseveration which could occur in the presence or absence of discrimination failure.

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Section: Discussionsupporting

confidence: 80%

Effects of chlordiazepoxide on cued radial maze performance in rats

Hodges

Green

1986

Psychopharmacology

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“…Therefore, postdrug list recall should be impaired, but recall for the pre-drug word list should be better for the diazepam group than for the placebo group. This effect has often been reported and is explained by a reduced interference of the post-drug words in the diazepam group (Ghoneim and Mewaldt, 1990 (Brown, Brown and Bowes, 1983).…”

Section: Introductionmentioning

confidence: 68%

“…Although these differences did not always reach significance, the pattern was remarkably consistent. Impairments of psychomotor performance has been frequently reported to be a consequence of BZD intake (Curran, Schifano and Lader, 1991;Ghoneim, Mewaldt and Hinrichs, 1984) (Brown, Brown and Bowes, 1983;Brown and Brown, 1990;Frith et al, 1984) and rate of rehearsal (Rich and Brown, 1992) are affected by diazepam.…”

Section: Discussionmentioning

confidence: 99%

Effects of diazepam on encoding processes

et al. 1995

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“…The results presented here could reconcile our observations of an impairment of semantic memory in general knowledge tasks with the preserved performances of lorazepam-treated participants in verbal fluency tasks. Some of the authors who have used fluency tasks have also observed a slowing down of reaction times (Brown, Brown, & Bowes, 1983;Green et al, 1996;Vermeeren et al, 1995). In verbal fluency tasks, the slowing down of the normal retrieval process induced by the drug does not affect its accuracy.…”

Section: Why Does the Phenomenology Of Tots Occur After Commissions Amentioning

confidence: 96%