Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity

Letari, Ornella; Miozzo, A.; Folco, Giancarlo; Belloni, P. A.; Sala, Angelo; Rovati, G. Enrico; Nicosia, S.

doi:10.1016/0922-4106(94)90130-9

Cited by 38 publications

(22 citation statements)

References 25 publications

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“…In this case, a secondary effect of the loratadine-inhibited adhesion on the LTB 4 release will probably unrelated to the inhibition of histamine receptors of neutrophils. 26,38 Activation of 5-lipneed to be demonstrated. Of interest, the release of LTB 4 by TNF--treated oxygenase in neutrophils requires arachidonic acid and superoxide anion generation.…”

Section: Effect Of Loratadine-treated Haec On Ltb 4 Effect Of Tnf--trmentioning

confidence: 99%

“…5F, smooth muscle. 26 and from human lung fragments 27 and platelets. 26 It is already known that Flow cytometric analysis of intercellular adhesion molecule-1 (ICAM-1) expression was performed.…”

Section: Increases Leukocyte Adherencementioning

confidence: 99%

“…26 and from human lung fragments 27 and platelets. 26 It is already known that Flow cytometric analysis of intercellular adhesion molecule-1 (ICAM-1) expression was performed. LTB 4 production is higher in blood neutrophils (PMN) from allergic subjects than in PMN from healthy HAEC monolayers were incubated for 48 h with a combination of TNF-(100 U/ml; concentration donors.…”

Section: Increases Leukocyte Adherencementioning

confidence: 99%

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Inhibitory Effect of Loratadine on Leukotriene B4Production by Neutrophils Either Alone or During Interaction with Human Airway Epithelial Cells

Amsellem

Czarlewski²,

Lagarde

et al. 1998

Pulmonary Pharmacology & Therapeutics

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Section: Effect Of Loratadine-treated Haec On Ltb 4 Effect Of Tnf--trmentioning

confidence: 99%

Section: Increases Leukocyte Adherencementioning

confidence: 99%

Section: Increases Leukocyte Adherencementioning

confidence: 99%

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Inhibitory Effect of Loratadine on Leukotriene B4Production by Neutrophils Either Alone or During Interaction with Human Airway Epithelial Cells

Amsellem

Czarlewski²,

Lagarde

et al. 1998

Pulmonary Pharmacology & Therapeutics

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“…These differences between our experiment and other studies can be explained through the following effects. Loratadine increases the cytosolic calcium by releasing it from intracellular stores (calcium activates NF-kB, increases the cytokines release), partially inhibits the leukotrienes as Letari et al [24] assessed in their research performed in vitro on rat peritoneal macrophages. Naclerio [25] in a study performed on nasal challenge antigen model and Shroeder et al [26] in their research in vitro on human basophils established that loratadine reduces the release of histamine and PGD 2, but not significantly.…”

Section: Livermentioning

confidence: 99%

Resveratrol and Loratadine Effects on Oxidative Stress Induced by Experimental Inflammation

Mitrea¹,

Clichici²,

Filip³

et al. 2017

Studia UBB Chemia

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ABSTRACT.Resveratrol is a polyphenol with important antioxidant and antiinflammatory roles. Loratadine, as a selective inverse-agonist of peripheral receptor H1, is described as an anti-allergic substance with potential antiinflammatory effects. We aimed to assess the protective capacity of loratadine against oxidative stress produced by inflammation with carrageenan in comparison with a well-known antioxidant compound, resveratrol.Our results showed that resveratrol and loratadine had no protective anti-inflammatory effects in inflamed skin. As expected, resveratrol had antioxidant effects in serum and in liver. Loratadine developed oxidative stress in tegument and serum.In this experimental model, our results do not sustain the initial hypothesis that loratadine could have a protective effect in inflammation, and, in the contrary, is capable of increasing it, by producing an oxidative stress.

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“…The mechanism of this elevation resides in the ability of LOR to discharge intracellular Ca 2+ stores, similarly to thapsigargin. One of the active metabolites of LOR, descarbo-ethoxy-loratadine, and another anti-histamine, namely terfenadine (TER), exhibit the same effects [150].…”

Section: Ah -Platelet Calcium and Atp-asesmentioning

confidence: 99%

Antiplatelet and Antileukocyte Effects of Cardiovascular,Immunomodulatory and Chemotherapeutic Drugs

Nosáľ¹

2006

CHAMC

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In vitro and ex vivo interactions of betaadrenoceptor blocking drugs, antihistamines and chloroquine with blood platelets and polymorphonuclear leukocytes resulted in different alterations of regulatory functions of these blood cells. Inhibition of platelet aggregation, arachidonate regulatory pathway, 5-hydroxytryptamine transportation, removal of platelet membrane receptors, inhibition of second messenger pathways at subcellular level and suppression of phagocytosis are indicative of nonreceptor rather than specific receptor interactions. Binding of drugs with biomembranes is reversible depending on the ionic charge of the molecule and hydrophobicity of the bilayer, partition coefficient, pH and pKa of the amphiphilic molecules and other physico-chemical properties of amphiphilic drugs. Alterations in the drug molecule structure alters the drug-phospholipid binding profile. Any change in the metabolism of membrane phospholipids directly or indirectly influences one or more of the important components of the phospholipid-signalling pathway. In addition to changes in phospholipase A, C and D activities, protein kinase C, calmodulin-phosphodiesterase, Ca2+,Mg2+-ATPase, Na+,K+-ATPase and other messengers were found to be changed in cells and tissue after cationic amphiphilic drug (CAD) administration. Although not much has been understood of the mechanism by which some CAD affect immune functions, there are good reasons to suggest that these effects might occur. CADs share sufficient similarities in their structure even though they come from diverse pharmacological classes. CADs affect ion transport, immune functions, tumour growth, serotonin metabolism and several other functions in the body. Extensive therapeutic use and associated side effects have generated a great deal of interest in understanding the nonreceptor interactions with CADs.

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Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity

Cited by 38 publications

References 25 publications

Inhibitory Effect of Loratadine on Leukotriene B4Production by Neutrophils Either Alone or During Interaction with Human Airway Epithelial Cells

Inhibitory Effect of Loratadine on Leukotriene B4Production by Neutrophils Either Alone or During Interaction with Human Airway Epithelial Cells

Resveratrol and Loratadine Effects on Oxidative Stress Induced by Experimental Inflammation

Antiplatelet and Antileukocyte Effects of Cardiovascular,Immunomodulatory and Chemotherapeutic Drugs

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