Inhibitory Effect of Loratadine on Leukotriene B4Production by Neutrophils Either Alone or During Interaction with Human Airway Epithelial Cells

Amsellem, Carole; Czarlewski, W.; Lagarde, Michel; Pachéco, Yves

doi:10.1006/pupt.1998.0151

Cited by 15 publications

(11 citation statements)

References 3 publications

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“…Loratadine is a very safe, potent, minimal sedation antihistamine with two important pharmacodynamic effects: (i) it decreases LTB4 production, 19,20 and (ii) it increases cellular cAMP content while decreasing the cGMP content 21…”

Section: Loratadinementioning

confidence: 99%

Cannabinoids, loratadine and allopurinol as novel additions to the antipsoriatic ammunition

Namazi

2005

Acad Dermatol Venereol

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As the current antipsoriatic medications are commonly associated with deleterious side-effects, a determined search for safer agents, which could be used alone or in combination with current antipsoriatic drugs, would be very imperative. Psoriasis is believed to be characterized by a type 1 cytokine pattern; interferon-gamma, interleukin (IL)-2 and tumour necrosis factor (TNF)-alpha are predominantly expressed in this disorder. Nitric oxide, reactive oxygen species, histamine, leukotriene B4, and decreased [corrected] keratinocyte cyclic adenosine monophosphate/cyclic guanosine monophosphate (cAMP/cGMP) ratio are supposed to play roles in the pathogenesis of this disorder. Based on the immunopathogenesis of psoriasis, this paper introduces three novel, potential treatments for this clinical conundrum: (i) cannabinoids, which exert inhibitory effects on antigen processing and macrophage/T-cell interaction and also on the release of IL-2, TNF-alpha and nitric oxide from immune cells; (ii) loratadine, which is an antihistamine capable of increasing [corrected] the cAMP/cGMP ratio and the production of leukotriene B4; and (iii) allopurinol, which scavenges free radicals, inhibits the production of TNF-alpha, and downregulates the expression of intercellular adhesion molecule-1 and P2X7 receptors on monocytes/macrophages, which are involved in antigen presentation and production of the inflammatory response, respectively. Importantly, allopurinol, especially in combination with cyclosporin, has been shown to be effective against experimental autoimmune uveitis, which, like psoriasis, is a cell-mediated autoimmune disorder.

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Section: Loratadinementioning

confidence: 99%

Cannabinoids, loratadine and allopurinol as novel additions to the antipsoriatic ammunition

Namazi

2005

Acad Dermatol Venereol

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“…LOR might reduce the inflammatory reaction by a direct effect on PMNL LTB 4 production in PMNL [305].…”

Section: Ah and Pmnl Functionsmentioning

confidence: 99%

Antiplatelet and Antileukocyte Effects of Cardiovascular,Immunomodulatory and Chemotherapeutic Drugs

Nosáľ¹

2006

CHAMC

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In vitro and ex vivo interactions of betaadrenoceptor blocking drugs, antihistamines and chloroquine with blood platelets and polymorphonuclear leukocytes resulted in different alterations of regulatory functions of these blood cells. Inhibition of platelet aggregation, arachidonate regulatory pathway, 5-hydroxytryptamine transportation, removal of platelet membrane receptors, inhibition of second messenger pathways at subcellular level and suppression of phagocytosis are indicative of nonreceptor rather than specific receptor interactions. Binding of drugs with biomembranes is reversible depending on the ionic charge of the molecule and hydrophobicity of the bilayer, partition coefficient, pH and pKa of the amphiphilic molecules and other physico-chemical properties of amphiphilic drugs. Alterations in the drug molecule structure alters the drug-phospholipid binding profile. Any change in the metabolism of membrane phospholipids directly or indirectly influences one or more of the important components of the phospholipid-signalling pathway. In addition to changes in phospholipase A, C and D activities, protein kinase C, calmodulin-phosphodiesterase, Ca2+,Mg2+-ATPase, Na+,K+-ATPase and other messengers were found to be changed in cells and tissue after cationic amphiphilic drug (CAD) administration. Although not much has been understood of the mechanism by which some CAD affect immune functions, there are good reasons to suggest that these effects might occur. CADs share sufficient similarities in their structure even though they come from diverse pharmacological classes. CADs affect ion transport, immune functions, tumour growth, serotonin metabolism and several other functions in the body. Extensive therapeutic use and associated side effects have generated a great deal of interest in understanding the nonreceptor interactions with CADs.

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“…Cheng et al [22] established on an experimental model performed on A549 cells that loratadine has anti-inflammatory effects through inhibition of IL-8. Amsellen et al [23] evaluated the loratadine effects on PMN cocultured with HAEC and assessed that anti-inflammatory effect is realized through reduction of LTB4 synthesis by neutrophils. From the best of our knowledge, loratadine was not used in a study on inflammation with carrageenan in rats, and in our study, we established that the administration of this selective inverse agonist of peripheral H 1 -receptors increases the paw's oedema.…”

Section: Livermentioning

confidence: 99%

Resveratrol and Loratadine Effects on Oxidative Stress Induced by Experimental Inflammation

Mitrea¹,

Clichici²,

Filip³

et al. 2017

Studia UBB Chemia

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ABSTRACT.Resveratrol is a polyphenol with important antioxidant and antiinflammatory roles. Loratadine, as a selective inverse-agonist of peripheral receptor H1, is described as an anti-allergic substance with potential antiinflammatory effects. We aimed to assess the protective capacity of loratadine against oxidative stress produced by inflammation with carrageenan in comparison with a well-known antioxidant compound, resveratrol.Our results showed that resveratrol and loratadine had no protective anti-inflammatory effects in inflamed skin. As expected, resveratrol had antioxidant effects in serum and in liver. Loratadine developed oxidative stress in tegument and serum.In this experimental model, our results do not sustain the initial hypothesis that loratadine could have a protective effect in inflammation, and, in the contrary, is capable of increasing it, by producing an oxidative stress.

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Inhibitory Effect of Loratadine on Leukotriene B4Production by Neutrophils Either Alone or During Interaction with Human Airway Epithelial Cells

Cited by 15 publications

References 3 publications

Cannabinoids, loratadine and allopurinol as novel additions to the antipsoriatic ammunition

Cannabinoids, loratadine and allopurinol as novel additions to the antipsoriatic ammunition

Antiplatelet and Antileukocyte Effects of Cardiovascular,Immunomodulatory and Chemotherapeutic Drugs

Resveratrol and Loratadine Effects on Oxidative Stress Induced by Experimental Inflammation

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