Effects of long-term treatment with angiotensin-converting enzyme inhibitors in the presence or absence of aspirin: A systematic review

Drug Interactions of Medications Commonly Used in Diabetes

“…Clinically, the interaction does not appear to affect the ACE inhibitor's ability to prevent adverse cardiovascular or renal outcomes. 41 ACE inhibitors may increase hypersensitivity reactions, such as flulike symptoms and skin rash, with allopurinol, although the exact mechanism is not known. 7 ACE inhibitors and ARBs may increase lithium levels, and concurrent use warrants close monitoring of lithium levels.…”

Controversies in Antiplatelet Therapy for Patients With Cardiovascular Disease

“…Although some retrospective analyses have suggested that coadministration of these drugs decreases the mortality benefit associated with ACEI therapy in patients with heart failure or ischemic heart disease, other studies have suggested that a decrease in mortality does not occur. 10 Because aspirin 81 mg/d has the same efficacy as 325 mg/d, with half the bleeding risk, 11 J.D. was advised to take the lower aspirin dose with the additional theoretical possibility that any interaction with his ACEI would be decreased.…”

Combination antihypertensive therapy in patients with arterial hypertension and coronary heart disease

“…АСК в дозах 75-325 мг в сутки является основным препаратом для вторичной профилактики кардио-васкулярных событий у больных с разными прояв-лениями ИБС -и при стабильной стенокардии, и с ОКС, и с постинфарктным кардиосклерозом, осложненным развитием ХСН. Также очень часто она используется в комбинации с ИАПФ [22]. Однако вопрос о целесообразности совместного применения ИАПФ и ацетилсалициловой кислоты вызывает много споров и до настоящего времени остается открытым [23].…”