Effects of Long-term Smoking on Myocardial Blood Flow, Coronary Vasomotion, and Vasodilator Capacity

Campisi, Roxana; Czernin, Johannes; Schöder, Heiko; Sayre, James W.; Marengo, Fernando D.; Phelps, Michael E.; Schelbert, Heinrich R.

doi:10.1161/01.cir.98.2.119

Cited by 163 publications

(122 citation statements)

References 52 publications

(42 reference statements)

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“…Second, smokers are likely to have atherosclerotic lesions, a local and chronic inflammation of vessel walls. Smokers have a tendency to have dyslipidemia, coronary vasomotor reactivity, platelet aggregation, and a prothrombotic state [36][37][38] . Accumulation of these risk factors promotes the initiation and progression of atherosclerosis.…”

Section: Fig 2 Relationships Of Hs-crp To Fasting Iri In Nonsmokersmentioning

confidence: 99%

High-Sensitivity CRP Reflects Insulin Resistance in Smokers

Hanyu

Yoshida

Abe

et al. 2009

JAT

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Section: Fig 2 Relationships Of Hs-crp To Fasting Iri In Nonsmokersmentioning

confidence: 99%

High-Sensitivity CRP Reflects Insulin Resistance in Smokers

Hanyu

Yoshida

Abe

et al. 2009

JAT

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“…9 -11 Moreover, smoking is associated with microvascular endothelial dysfunction that may limit the ability of epicardial revascularization to restore normal coronary blood flow. 12,13 Finally, recent studies have shown that smoking is associated with reduced exercise capacity after PTCA 14 and impaired functional capacity after bypass surgery. 15 Little is known, however, about the specific effects of smoking on overall health-related quality of life after PTCA.…”

Section: See P 1340mentioning

confidence: 99%

Impact of Smoking on Health-Related Quality of Life After Percutaneous Coronary Revascularization

Taira

Seto

et al. 2000

Circulation

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Background-PTCA is performed primarily to improve health-related quality of life (HRQOL) in patients with symptomatic coronary artery disease. In patients undergoing PTCA, smoking has been shown to increase risks of late myocardial infarction and death. Whether smoking also affects HRQOL after PTCA is currently unknown. Methods and Results-We examined the relation between smoking status and HRQOL among 1432 patients who underwent PTCA as part of 2 multicenter clinical trials. HRQOL was assessed with the use of the Medical Outcomes Study SF-36 questionnaire. Patients were classified as smokers (nϭ301), quitters (nϭ141), or nonsmokers (nϭ990) on the basis of their smoking status at the time of their index procedure and during the first year of follow-up. For the overall population, HRQOL improved significantly after PTCA for all scales except general health perception, with improvements ranging from 5.5 points for mental health to 23.2 points for role-physical functioning. After adjustment for baseline characteristics and initial HRQOL, nonsmokers had gains at 6 months that were larger than those of smokers for all health domains: physical function (15.4 versus 10.4 points), role-physical (24.5 versus 13.9), pain (18.4 versus 13.3), general health perception (1.7 versus Ϫ4.5), vitality (11.0 versus 4.7), social function (12.8 versus 3.5), role-emotional (13.5 versus 6.7), and mental health (6.8 versus 0.8; PϽ0.02 for all comparisons). Quitters had 6-month HRQOL improvements that were greater than those in smokers for all domains as well. Findings were similar at 1 year. Conclusions-Quality-of-life benefits of PTCA are diminished by continued smoking. Efforts to promote smoking cessation at the time of PTCA may substantially improve the health outcomes of these procedures. (Circulation.

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“…Coronary endothelial dysfunction is the earliest abnormality in the development of coronary atherosclerosis and is also independently associated with future cardiac events [2]. Several coronary risk factors adversely affect endothelial function [3][4][5][6]. Among these risk factors, smoking is the leading cause of preventable cardiovascular death and is a related factor in more than 450,000 deaths annually in the United States [7].…”

Section: Introductionmentioning

confidence: 99%