Effects of Long-term Ingestion of Wheat Albumin in Mild Non-insulin-dependent Diabetes Mellitus.

Morimoto, Toshihisa; Tanaka, Shun‐ichi; Miyazaki, Toshiyuki; Kodama, Toshiaki; Kitamura, Ikuo; Inoue, Shuji

doi:10.4327/jsnfs.52.293

Cited by 9 publications

(5 citation statements)

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“…To date, there are many studies on the control of the blood glucose level for the prophylaxis of diabetic disease by physiologically functional food materials ( − ). In this study, we have proved that some anthocyanin extracts from plants possess potent AGH and α-amylase inhibitory activities.…”

Section: Discussionmentioning

confidence: 99%

α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins. 1. Survey of Natural Pigments with Potent Inhibitory Activity

Matsui

Ueda

Oki

et al. 2001

J. Agric. Food Chem.

368

212

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alpha-Glucosidase (AGH) inhibitory study by natural anthocyanin extracts was done. As the result of a free AGH assay system, 12 anthocyanin extracts were found to have a potent AGH inhibitory activity; in particular, Pharbitis nil (SOA) extract showed the strongest maltase inhibitory activity, with an IC(50) value of 0.35 mg/mL, as great as that of Ipomoea batatas (YGM) extract (IC(50) = 0.36 mg/mL). Interestingly, neither extract inhibited the sucrase activity at all. For the immobilized assay system, which may reflect the pharmacokinetics of AGH at the small intestine, SOA and YGM extracts gave more potent maltase inhibitory activities than those of the free AGH assay, with IC(50) values of 0.17 and 0.26 mg/mL, respectively. Both extracts also inhibited alpha-amylase action, indicating that anthocyanins would have a potential function to suppress the increase in postprandial glucose level from starch.

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Section: Discussionmentioning

confidence: 99%

α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins. 1. Survey of Natural Pigments with Potent Inhibitory Activity

Matsui

Ueda

Oki

et al. 2001

J. Agric. Food Chem.

368

212

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“…Prevention of the development of its subsequent combined diseases such as retinopathy, neuropathy and cataracts1 is also of great importance clinically. In the field of food science, much interest has been focused on the development of alternative medicinal foods with the ability to regulate excess BGL rise 2, 3. This is because any control of postprandial BGL rise by antihyperglycaemic foods would be of benefit in improving the quality of life of people with borderline NIDDM.…”

Section: Introductionmentioning

confidence: 99%

Suppression of blood glucose level by a new fermented tea obtained by tea‐rolling processing of loquat (Eriobotrya japonica) and green tea leaves in disaccharide‐loaded Sprague‐Dawley rats

et al. 2010

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“…One successful approach to achieve optimal BGL is through retardation of α-glucosidase (AGH, EC 3.2.1.20) activity (), in a fashion similar to that of acarbose [a membrane-bound sucrase−isomaltase (SI) complex] in the small intestine (). Clinical indications of some anti-hyperglycemic foods have demonstrated the efficacy of food intake on postprandial BGL control ( , ), all of which involve the inhibition or delay of glucose production from carbohydrates.…”

Section: Introductionmentioning

confidence: 99%

α-Glucosidase Inhibitory Profile of Catechins and Theaflavins

Matsui

Tanaka

Tamura

et al. 2006

J. Agric. Food Chem.

310

192

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To clarify the postprandial glucose suppression effect of flavonoids, the inhibitory effects of catechins and theaflavins against alpha-glucosidase (AGH) were examined in this study. It was initially demonstrated that theaflavins and catechins preferentially inhibited maltase rather than sucrase in an immobilized AGH inhibitory assay system. For the maltase inhibitory effects of theaflavins, the effects were observed in descending order of potency of theaflavin (TF)-3-O-gallate (Gal) > TF-3,3'-di-O-Gal > TF-3'-O-Gal > TF. This suggests that the AGH inhibition induced by theaflavins is closely associated with the presence of a free hydroxyl group at the 3'-position of TF as well as the esterification of TF with a mono-Gal group. In addition, the R-configuration at the 3'-position of TF-3-O-Gal showed a higher inhibitory activity than the S-configuration. As a result of a single oral administration of maltose (2 g/kg) in rats, a significant reduction in blood glucose level was observed at a dose of 10 mg/kg of TF-3-O-Gal, demonstrating for the first time that TF-3-O-Gal can suppress glucose production from maltose through inhibition of AGH in the gut.

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Effects of Long-term Ingestion of Wheat Albumin in Mild Non-insulin-dependent Diabetes Mellitus.

Cited by 9 publications

References 0 publications

α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins. 1. Survey of Natural Pigments with Potent Inhibitory Activity

α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins. 1. Survey of Natural Pigments with Potent Inhibitory Activity

Suppression of blood glucose level by a new fermented tea obtained by tea‐rolling processing of loquat (Eriobotrya japonica) and green tea leaves in disaccharide‐loaded Sprague‐Dawley rats

α-Glucosidase Inhibitory Profile of Catechins and Theaflavins

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