Effects of long‐term exercise training for different durations on pancreatic amylase activity and intestinal glucose transporter content in rats

Kondo, Shu; Fukazawa, Ayumi; Karasawa, Takuya; Terada, Shin

doi:10.14814/phy2.14255

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…Therefore, we assumed that the exercise-induced trend toward increased GLUT2 and SGLT1 in this study was induced via GLP-2 signaling. It has been reported that 6 wk of swimming training increased the expression of SGLT1, which was explained as an adaptation of the intestine to long-term exercise [15]. As the exercise style of this study was treadmill running, whereas that of the previous study was swimming, it was not possible to make a general comparison; however, GLP-2 might be a key factor in the adaptation of the intestine to exercise.…”

Section: Discussionmentioning

confidence: 66%

“…Motiani et al reported that 2 wk of moderate intensity training increased the expression level of glucose transporter 2 (GLUT2) in the intestine of mice [14]. In addition, Kondo et al reported that 6 wk of swimming exercise induced substantial adaptations in the digestive capability of the pancreas and absorptive capability in the small intestine in rats [15]. Therefore, exercise might be effective in improving the digestive and absorptive molecules of carbohydrates in the small intestine.…”

Section: Introductionmentioning

confidence: 99%

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Acute Low-intensity Treadmill Running Induces Intestinal Glucose Transporters via GLP-2 in Mice

Aoki¹,

Suzuki²,

F³

et al. 2021

Preprint

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Exercise affects various organs. However, its effects on nutrient digestion and absorption in the intestinal tract are not well understood. A few studies have reported that exercise training in-creases the expression of carbohydrate digestion and absorption molecules. Exercise was also shown to increase the concentration of blood glucagon like peptide-2(GLP-2), which regulates carbohydrate digestion and absorption in small intestinal epithelium. Therefore, we investigated the effects of exercise on intestinal digestion and absorption molecules and the levels of GLP-2. 6-wk-old of male mice were divided into 2 groups; sedentary (SED) and low-intensity exercise (LEx). LEx mice were required to run on a treadmill (12.5 m/min, 60 min), whereas SED mice rested. All mice were euthanized 1 h after exercise or rest and plasma, jejunum, ileum, and colon were sampled. Samples were analyzed using EIA and immunoblotting. The levels of plasma GLP-2 and the expression of the GLP-2 receptor, sucrase-isomaltase (SI), and glucose transporter (GLUT2) in the jejunum were increased in LEx group. We showed that acute low-intensity exer-cise affects the intestinal carbohydrate digestion and absorption molecules via GLP-2. Our results suggest that exercise might provide new benefits to the small intestine for people with intestinal frailty.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Acute Low-intensity Treadmill Running Induces Intestinal Glucose Transporters via GLP-2 in Mice

Aoki¹,

Suzuki²,

F³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Therefore, we assumed that the exercise-induced increase of GLUT2 and SGLT1 in this study might be mediated via GLP-2 signaling. Six weeks of swimming training were reported to upregulate SGLT1, deemed as an adaptative response of the intestine to long-term exercise [15]. The present study explored the effects of a 1 h treadmill run as a form of acute exercise.…”

Section: Discussionmentioning

confidence: 99%

“…Motiani et al reported that two weeks of moderate-intensity training upregulated the expression of glucose transporter 2 (GLUT2) in the intestines of mice [14]. Kondo et al reported that six weeks of swimming exercise induced substantial alterations in pancreatic digestive capability as well as in the absorptive capability of the small intestine in rats [15]. Therefore, exercise might be effective in improving the digestion and absorption of carbohydrates within the small intestine.…”

Section: Introductionmentioning

confidence: 99%

Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice

et al. 2021

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The effects of exercise on nutrient digestion and absorption in the intestinal tract are not well understood. A few studies have reported that exercise training increases the expression of molecules involved in carbohydrate digestion and absorption. Exercise was also shown to increase the blood concentration of glucagon-like peptide-2 (GLP-2), which regulates carbohydrate digestion and absorption in the small intestine. Therefore, we investigated the effects of exercise on the expression of molecules involved in intestinal digestion and absorption, including GLP-2. Six-week-old male mice were divided into a sedentary (SED) and low-intensity exercise (LEx) group. LEx mice were required to run on a treadmill (12.5 m/min, 1 h), whereas SED mice rested. All mice were euthanized 1 h after exercise or rest, and plasma, jejunum, ileum, and colon samples were collected, followed by analysis via IHC, EIA, and immunoblotting. The levels of plasma GLP-2 and the jejunum expression of the GLP-2 receptor, sucrase-isomaltase (SI), and glucose transporter 2 (GLUT2) were higher in LEx mice. Thus, we showed that acute low-intensity exercise affects the expression of molecules involved in intestinal carbohydrate digestion and absorption via GLP-2. Our results suggest that exercise might be beneficial for small intestine function in individuals with intestinal frailty.

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“…Among the known symptoms of digestive enzymes deficiency are food intolerances, poor nutrient absorption, a weaker immune system, weight gain and obesity, skin and digestive problems, etc. Moreover, long-term endurance training for a long duration causes changes in the activity of digestive enzymes (e.g., pancreatic amylase) [ 184 ]. The supplementation of digestive enzymes by athletes is, apart from a method to alleviate unpleasant symptoms, one of the methods of improving sports performance.…”

Section: The Inhibition Of Digestive Enzymes By Polyphenolic Compoundsmentioning

confidence: 99%

Possible Side Effects of Polyphenols and Their Interactions with Medicines

Duda-Chodak

Tarko

2023

Molecules

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Polyphenols are an important component of plant-derived food with a wide spectrum of beneficial effects on human health. For many years, they have aroused great interest, especially due to their antioxidant properties, which are used in the prevention and treatment of many diseases. Unfortunately, as with any chemical substance, depending on the conditions, dose, and interactions with the environment, it is possible for polyphenols to also exert harmful effects. This review presents a comprehensive current state of the knowledge on the negative impact of polyphenols on human health, describing the possible side effects of polyphenol intake, especially in the form of supplements. The review begins with a brief overview of the physiological role of polyphenols and their potential use in disease prevention, followed by the harmful effects of polyphenols which are exerted in particular situations. The individual chapters discuss the consequences of polyphenols’ ability to block iron uptake, which in some subpopulations can be harmful, as well as the possible inhibition of digestive enzymes, inhibition of intestinal microbiota, interactions of polyphenolic compounds with drugs, and impact on hormonal balance. Finally, the prooxidative activity of polyphenols as well as their mutagenic, carcinogenic, and genotoxic effects are presented. According to the authors, there is a need to raise public awareness about the possible side effects of polyphenols supplementation, especially in the case of vulnerable subpopulations.

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Effects of long‐term exercise training for different durations on pancreatic amylase activity and intestinal glucose transporter content in rats

Cited by 7 publications

References 30 publications

Acute Low-intensity Treadmill Running Induces Intestinal Glucose Transporters via GLP-2 in Mice

Acute Low-intensity Treadmill Running Induces Intestinal Glucose Transporters via GLP-2 in Mice

Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice

Possible Side Effects of Polyphenols and Their Interactions with Medicines

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