Effects of Long-Term Administration of Hesperidin and Glucosyl Hesperidin to Spontaneously Hypertensive Rats.

Effects of Glucosyl Hesperidin on Serum Lipids in Hyperlipidemic Subjects: Preferential Reduction in Elevated Serum Triglyceride Level

“…G Hesperidin is soluble in water, and its solubility is about 10,000 times greater than that of conventional hesperi din (17). Moreover, it has been verified that this deriva tive releases hesperidin through hydrolysis by brush border a-glucosidases and results in the exhibition of physiological activities (17,18). We have also found that the supplementation of G-hesperidin significantly lowered serum TG in hyperlipidemic mice and that the lowering effect was probably due to hesperidin released in vivo (19).…”

Glucosyl Hesperidin Lowers Serum Triglyceride Level in Hypertriglyceridemic Subjects through the Improvement of Very Low-Density Lipoprotein Metabolic Abnormality

“…Our recent studies have shown that G-hesperidin as well as hesperidin exhibits such physiological activities as decrease of serum lipid peroxide level in hyperlipidemic mice (6), antihypertensive effect on spontaneously hypertensive rats ( 7,8) and suppression of passive cuta neous anaphylaxis in rats (9). These findings indicate that G-hesperidin behaves as hesperidin in the body and results in the exhibition of physiological activities.…”

Bioavailability of Glucosyl Hesperidin in Rats

“…The safety of G-hesperidin has also been confirmed in long-term administration studies using mice and rats. 6,31) In a human study, no clinical changes related to 24-week administration of G-hesperidin were observed in subjects. 32) Hence the safety of G-hesperidin is considered to be comparable to that of hesperidin.…”