Effects of locus MN on diastolic blood pressure in a human population

A Search for Associations between Genetical Polymorphic Systems and Physical, Biochemical and Haematological Variables

“…Thus. Cruz-Coke et al [2] concluded that the MN locus constituted a relatively important source of variation of blood pressure since they found a dosage effect of the N allele determining an increase in diastolic pressure in a very small population sample. N ance et al [7] studied a much larger sample and concluded that the diastolic blood pressure of group O individuals was significantly higher than that of their siblings of other ABO types.…”

Do the MN and Jk systems influence environmental variability in serum lipid levels?

“…Because hyperlipidaemia is a risk factor for coronary heart disease (Goldstein et al 1973) we may therefore expect that MN blood group may be as well. Association of MN blood group with another CHD risk factor, hypertension, has been reported by Cruz-Coke et al (1964) who found a significantly higher diastolic blood pressure in NN than MM individuals and they also observed, but did not comment on, a greater variance in the NN blood group (P = 0.06, 2 tail). A number of associations of the MN blood group with hypertension and various forms of coronary heart disease have been reported, although these are inconsistent in that some groups show an elevated risk of blood group N and others of group M (Mourant et al 1978).…”

Association of blood groups with essential and secondary hypertension. A possible association of the MNS system.

“…5 The present investigation failed to demonstrate any association of blood group O with increased blood pressure as reflected in the occurrence of essential hypertension, nor were there seen quantitative differences in blood pressure among groups. The current study population is quite different from that of Nance et al 6 In contrast to their very large rural population with inadequte medical care, the current investigation contains both rural and urban populations with above average medical care.…”

“…In 1964, Cruz-Coke et al 6 reported that changes in blood pressure that occurred in Easter Islanders who migrated behaved differently in subjects differing in the MN system. Under the influence of the new environment, genotypes MM and NN reacted in opposite ways, and further analysis of the phenotypic variation of blood pressure indicated that a substantial portion (0.246) could be attributed to the effects of these genes.…”

“…5 A population study of Easter Islanders migrating to Chile on the South American continent reported that the MN system may influence the developrrtent of increased diastolic blood pressure attributable to the environmental changes, with NN genotypes showing the greatest blood pressure increase. 6 The gene frequencies were not different in the continental and island populations, so the results could not be attributed to selective migration. Their results showed an increased variance in diastolic blood pressure in the Easter Islanders when they migrated to the continent with blood pressures of the two homozygous (MM and NN) groups reacting in opposite ways.…”