Association of blood groups with essential and secondary hypertension. A possible association of the MNS system.

Miller, Judy Z.; Grim, Clarence E.; Conneally, P. M.; Weinberger, Myron H.

doi:10.1161/01.hyp.1.5.493

Cited by 14 publications

(7 citation statements)

References 18 publications

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“…However, there were significant differences in the frequencies of the MNS blood group antigens when comparing normotensive controls with individuals who had essential or renovascular hypertension; when compared to normotensives, essential hypertensives were significantly different among Whites, while a similar difference was not seen among Blacks . Three distinctly different phenotypic frequencies were seen when individuals with atherosclerotic renovascular hypertension were compared to essential hypertensives and normotensives …”

Section: Cancermentioning

confidence: 89%

“…Essential hypertension is diagnosed when secondary forms of hypertension can be ruled out, but it can also be diagnosed due to renal stenosis (renovascular hypertension), atherosclerotic or fibromuscular etiology, or primary aldosteronism associated with low plasma renin levels; individuals with these conditions were compared to normotensive controls and to individuals with secondary hypertension, and no significant differences were found in ABO, Rh, Kidd, Kell, Duffy, P, haptoglobin, PGM‐1, or acid phosphatase systems . However, there were significant differences in the frequencies of the MNS blood group antigens when comparing normotensive controls with individuals who had essential or renovascular hypertension; when compared to normotensives, essential hypertensives were significantly different among Whites, while a similar difference was not seen among Blacks . Three distinctly different phenotypic frequencies were seen when individuals with atherosclerotic renovascular hypertension were compared to essential hypertensives and normotensives …”

Section: Cancermentioning

confidence: 99%

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Blood type biochemistry and human disease

Ewald

Sumner

2016

WIREs Mechanisms of Disease

124

163

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Associations between blood type and disease have been studied since the early 1900s when researchers determined that antibodies and antigens are inherited. In the 1950s, the chemical identification of the carbohydrate structure of surface antigens led to the understanding of biosynthetic pathways. The blood type is defined by oligosaccharide structures, which are specific to the antigens, thus, blood group antigens are secondary gene products, while the primary gene products are various glycosyltransferase enzymes that attach the sugar molecules to the oligosaccharide chain. Blood group antigens are found on red blood cells, platelets, leukocytes, plasma proteins, certain tissues, and various cell surface enzymes, and also exist in soluble form in body secretions such as breast milk, seminal fluid, saliva, sweat, gastric secretions, urine, and amniotic fluid. Recent advances in technology, biochemistry, and genetics have clarified the functional classifications of human blood group antigens, the structure of the A, B, H, and Lewis determinants and the enzymes that produce them, and the association of blood group antigens with disease risks. Further research to identify differences in the biochemical composition of blood group antigens, and the relationship to risks for disease, can be important for the identification of targets for the development of nutritional intervention strategies, or the identification of druggable targets.

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Section: Cancermentioning

confidence: 89%

Section: Cancermentioning

confidence: 99%

Blood type biochemistry and human disease

Ewald

Sumner

2016

WIREs Mechanisms of Disease

124

163

View full text Add to dashboard Cite

show abstract

“…Urinary excretion of sodium, potassium, and creatinine also was measured. Genetic markers were originally measured by the Department of Medical Genetics to examine associations with secondary forms of hypertension 12 and included haptoglobin (Hp) phenotypes, ABO Rh, secretor, MNS, Kell, Duffy, Kidd, P, parotid double band protein, phosphoglucomutase-1 and acid phosphatase in a group of 202 normotensive and essential hypertensive subjects.…”

Section: Methodsmentioning

confidence: 99%

Association of haptoglobin with sodium sensitivity and resistance of blood pressure.

et al. 1987

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SUMMARY Sodium sensitivity and resistance of blood pressure were examined in 117 normotensive and 85 hypertensive subjects by means of a protocol using rapid extracellular fluid volume expansion with intravenously administered saline (2 L over 4 hours) followed by a day of low dietary sodium intake (10 m£q) and volume contraction induced by a diuretic (furosemide, 120 mg orally). Genetic markers were also examined. Both hypertensive and normotensive subjects with haptoglobin 1-1 phenotype were significantly more (p<0.05) likely to be sodium-sensitive than were those with 2-1 or 2-2 phenotypes, and subjects with 2-2 phenotypes were more apt to be sodium-resistant. A second population was examined in which both adults and children with haptoglobin 1-1 phenotype were found to have significantly (p<0.05) higher casual systolic and diastolic blood pressures. These two studies independently confirm a relationship between haptoglobin phenotypes and blood pressure and suggest an environmental factor (sodium) as well. (Hypertension 10: 445-446, 1987) KEYWORDS hypertension blood pressure • sodium sensitivity • sodium resistance • haptoglobin T

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“…Determination of the association of ABO blood group with disease is an interesting area of research due to the ease of testing these antigens and their inheritance from one generation to the next. As a result, the understanding of ABO antigen has grown up and the clinical significance of blood groups has extended beyond transfusion medicine and organ transplantation (1,(3)(4)(5)(6). ABO blood group antigens become well-known genetic risk factors for diseases such as gastric malignancies, cognitive impairment, metabolic diseases, thrombotic cardiovascular adverse events, life expectancy, etc (3,(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

ABO Blood Type does not Influence Blood Pressure Levels in Healthy Indian Adolescents

Siddiqui

Soni

Gaur

et al. 2021

RABMS

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Background & Aims: ABO blood group antigens are well known genetic risk factors for various diseases. These antigens were reported as a non-modifiable risk factor for the development of hypertension independent of conventional modifiable risk factors. These findings were based on populations with pre-existing hypertension; however, such a relationship was rarely evaluated in normal healthy subjects. Materials & Methods:This cross-sectional study consisted of 400 healthy adolescents (203 males and 197 females) aged 17 to 25 years. The slide agglutination method was used for the determination of ABO blood typing. A standardized mercury sphygmomanometer was used for recording BP. Pulse Pressure (PP) and Mean Arterial Pressure (MAP) were also calculated. JNC-8 guidelines were used for calculation of the prevalence of elevated BP across ABO groups. ANOVA test was used to compare BP values in ABO blood groups. Chi-square correlation was used to assess frequency distribution of ABO blood groups among hypertensive and normal subjects.Results: Blood group B was most prevalent (35.2%) in our study. The highest average values of SBP DBP, PP, and MAP were recorded in blood group AB. The observed differences in the mean values of BP indices across ABO blood groups were statistically insignificant.Maximum subjects with elevated blood pressure were found in blood group A (n=12;10.81%) but no significant association was observed between ABO blood groups and elevated blood pressure. Conclusion:Tendencies for developing elevated BP levels have no significant association with ABO blood groups in young healthy subjects of any gender.

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Association of blood groups with essential and secondary hypertension. A possible association of the MNS system.

Cited by 14 publications

References 18 publications

Blood type biochemistry and human disease

Blood type biochemistry and human disease

Association of haptoglobin with sodium sensitivity and resistance of blood pressure.

ABO Blood Type does not Influence Blood Pressure Levels in Healthy Indian Adolescents

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