Effects of local irritation and dextran sulphate administration on the periodontium of the rat

Abstract

Local irritation, provided by means of silk ligatures at the necks of mandibular first molars of rats, caused significant resorption of crestal alveolar bone. This resorption did not change significantly in extent from 27 days after placement of the ligatures. However, in rats receiving injections of dextran sulphate, there was no significant reduction in height of crestal alveolar bone of non‐ligated mandibular first molars. The injections of dextran sulphate caused the appearance of large numbers of multinucleated osteoclasts adjacent to the alveolar bone surrounding the mandibular molar teeth. There was increased irregularity of the periodontal surface of this alveolar bone. When the local and general factors were combined there was a significant increase in resorption of the crestal alveolar bone mesial to the mandibular first molars at 37 days after placement of ligatures. The systemic agent was seen to augment the effects of the local irritant beyond the time at which local irritation alone ceased to have any demonstrable effect.

Selective cyclooxygenase-2 inhibition prevents bone resorption

“…The groups with ligature around the mandibular right first molar 11 had an initial gingival lesion, and this fact provoked the dilatation of the microvascular net of the region, with an increase in the hydrostatic pressure and fluid permeability, and also in the displacement of the leucocytes to the crevicular gingival fluid; cell response had been well established between two and four days. In this study, the group treated with meloxicam did not show results statistically different from the group not treated with meloxicam when the treatment was performed for 15 days (groups VII and VIII (p > 0.05)).…”

“…Thus, the activation of other inflammatory mediators can be explained by the absence of the inhibition of bone resorption found in the groups treated with meloxicam in the available periods 11 . Meloxicam and other NSAIDs may be considered promising agents in the treatment of periodontal disease, but other studies may be necessary and should be idealized to explore the various aspects that are not yet elucidated.…”

Periodontal Disease-Associated Compensatory Expression of Osteoprotegerin Is Lost in Type 1 Diabetes Mellitus and Correlates with Alveolar Bone Destruction by Regulating Osteoclastogenesis

“…PD was induced by ligature with No. 10 cotton thread tied bilaterally around the lower first molar, according to Johnson [1975].…”

Local application of statins in the treatment of experimental periodontal disease in rats

“…10 cotton thread (current cotton no. 10; Coats Corrente; São Paulo; SP; Brazil) was adapted around the left first mandibular molars and kept in position by means of surgical knots 13 .…”