Effects of Lipid Peroxidation-Related Protein Modifications on RPE Lysosomal Functions and POS Phagocytosis

Kaemmerer, Elke; Schütt, F.; Krohne, Tim U.; Holz, Frank G.; Kopitz, Jürgen

doi:10.1167/iovs.06-0549

Cited by 115 publications

(81 citation statements)

References 33 publications

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“…14 generation of toxic intermediates, with consequent activation of the inflammatory cascade, either via direct complement activation or indirectly by inducing tissue injury and triggering apoptosis (Beattie, 2009;Dasari et al, 2010;Kaemmerer et al, 2007). Dendritic cells are subsequently recruited (Hageman et al, 2001).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes

Khan

Mahroo

Khan

et al. 2016

Progress in Retinal and Eye Research

166

152

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Drusen are discussed frequently in the context of their association with age-related macular degeneration (AMD). Some types may, however, be regarded as a normal consequence of ageing; others may be observed in young age groups. They also occur in a number of inherited disorders and some systemic conditions. Whilst drusen are classically located external (sclerad) to the retinal pigment epithelium, accumulations of material internal (vitread to) this layer can display a drusen-like appearance, having been variously termed pseudodrusen or subretinal drusenoid deposits. This review first briefly presents an overview of drusen biogenesis and subclinical deposit. The (frequently overlapping) subtypes of clinically detectable deposit, seen usually in the context of ageing or AMD, are then described in more detail, together with appearance on imaging modalities: these include hard and soft drusen, cuticular drusen, reticular pseudodrusen and "ghost drusen". Eye disorders other than AMD which may exhibit drusen or drusen-like features are subsequently discussed: these include monogenic conditions as well as conditions with undefined inheritance, the latter including some types of early onset drusen such as large colloid drusen. A number of systemic conditions in which drusen-like deposits may be seen are also considered. Throughout this review, high resolution images are presented for most of the conditions discussed, particularly the rarer ones, providing a useful reference library for images of the range of conditions associated with drusen-like appearances. In the final section, some common themes are highlighted, as well as a brief discussion of some future avenues for research.

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes

Khan

Mahroo

Khan

et al. 2016

Progress in Retinal and Eye Research

166

152

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“…Several studies have focused on homocysteine and lipid peroxidation in AMD; however, only one study on the PON1 activity and lipid peroxidation status of patients with active AMD is available (Baskol et al 2004;Kamburoglu et al 2006;Seddon et al 2006;Kaemmerer et al 2007). In the present study, we investigated the relationship between serum PON1 activity and homocysteine and MDA in AMD.…”

mentioning

confidence: 99%

Decreased Serum Paraoxonase 1 Activity and Increased Serum Homocysteine and Malondialdehyde Levels in Age-Related Macular Degeneration

Ateş

Azizi

Hakan

et al. 2009

Tohoku J. Exp. Med.

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“…[24][25][26][27][28][29][30][31] Evidências epidemiológicas, clínicas e experimentais indicam que o acúmulo de lipofuscina no EPR precede a atrofia das camadas celulares da retina externa, incluindo degeneração de fotorreceptores e atrofia do pró-prio EPR. 26,30,[32][33][34] A perda da função visual também em patologias heredodistróficas como Doença de Stargardt e Doença de Best tem sido atribuída ao acúmulo anormal de lipofuscina no EPR e/ou no espaço sub-retiniano. Figura 5.…”

Section: Figuraunclassified

Avaliação ocular multimodal em doenças heredodistróficas e degenerativas da retina

Ferrara¹,

Calucci²,

Oréfice³

et al. 2009

Rev. bras.oftalmol.

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RESUMOA tomografia de coerência óptica incorporou-se gradativamente ao contemporâneo arsenal diagnóstico em Oftalmologia, passando a exercer papel fundamental na investigação e condução de doenças oculares, particularmente na especialidade de Retina e Vítreo. A disponibilização comercial da nova geração de aparelhos, chamada de tomografia de coerência óptica "espectral", baseada em conceito físico distinto que permite a aquisição de imagens em alta velocidade, marcou o início de uma nova era desta tecnologia de investigação auxiliar. Adicionalmente, sua recente combinação com o oftalmoscópio de varredura a laser confocal (confocal scanning laser ophthalmoscope) vem propiciando a aquisição de imagens tomográficas guiadas em tempo real pelos diferentes modos de imagem (autofluorescência de fundo, reflectância com luz "infravermelha" e angiografia com fluoresceína ou indocianina verde). A avaliação ocular multimodal (multimodal fundus imaging) permite a correlação real e minuciosa de achados da morfologia retiniana e do epitélio pigmentar com dados de estudos angiográficos e de autofluorescência ou reflectância, propiciando assim inferências valiosas sobre a fisiologia do tecido. Neste artigo, discutimos brevemente as possíveis implicações da avaliação ocular multimodal na prática da especialidade de Retina e Vítreo.

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Effects of Lipid Peroxidation-Related Protein Modifications on RPE Lysosomal Functions and POS Phagocytosis

Abstract: The results indicate that lipid peroxidation-derived protein modifications are involved in lipofuscinogenesis and may contribute to cell damaging effects of lipofuscin in retinal diseases such as AMD.

Cited by 115 publications

References 33 publications

Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes

Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes

Decreased Serum Paraoxonase 1 Activity and Increased Serum Homocysteine and Malondialdehyde Levels in Age-Related Macular Degeneration

Avaliação ocular multimodal em doenças heredodistróficas e degenerativas da retina

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