Effects of light-emitting diode irradiation on RANKL-induced osteoclastogenesis

Abstract

Taken together, the results presented herein show that LED irradiation downregulates osteoclastogenesis by reducing ROS production. Therefore, LED irradiation/LLLT might be useful as an alternative, conservative approach to osteoporosis management.

Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light

“…To date, only a handful of studies have evaluated the effects of PBM on Nrf2 expression and activity. Interestingly, Sohn et al reported an increase in Nrf2 gene expression following irradiation at 635 nm (140). Similarly, Trotter et al also found that application of blue light induced significant increases in Nrf2 expression in vitro (141).…”

Photobiomodulation with red light‐emitting diodes accelerates hepatocyte proliferation through reactive oxygen species/extracellular signal‐regulated kinase pathway

“…The use of LED irradiation in PBT has already been determined in terms of its positive role in the stimulation of neuronal growth, post‐ischemia skeletal muscle protective effects, protection of cardiomyocytes, acceleration of wound healing, reduction of the inflammatory response, and cellular proliferation and differentiation . In this study, it has been determined that red LED irradiation also has an effect on hepatocyte proliferation.…”

“…Photobiomodulation therapy modulates cell function mainly through the photoreceptors existing in cells that can achieve activation transformation after absorbing the energy of light, including metabolism, mitosis, and apoptosis. Ulteriorly, it achieves biological effects, such as promoting wound healing, neurite growth acceleration, and the increase of stem cell differentiation . Different from short‐wavelength visible light, which mainly correlates to cell apoptosis, red light can be specifically absorbed by cytochrome c oxidase, and which plays an essential role in mitochondrial respiration and electron transport, increasing adenosine triphosphate and reactive oxygen species (ROS) production and affecting various biological processes .…”

The Effects of Photobiomodulation on MC3T3-E1 Cells via 630 nm and 810 nm Light-Emitting Diode

“…Beyond its effects on osteoblasts, some studies have also demonstrated the potential of PBM to inhibit osteoclastogenesis [41,42]. Reduced ROS production has been proposed as a possible cause of reduced osteoclastogenesis following irradiation [41–43]. Moreover, many studies found that PBM could promote bone healing and improve bone quantity and strength in ovariectomized rats [39,40,44–46], in which near infrared light was more commonly used.…”