Effects of Lidocaine on the Anesthetic Requirements for Nitrous Oxide and Halothane

Himes, Richard S.; DiFazio, Cosmo A.; Burney, Robert G.

doi:10.1097/00000542-197711000-00010

Cited by 143 publications

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“…A analgesia per-operatória promovida pela peridural sacra possibilitou que os pacientes fossem mantidos sob anestesia geral com a fração expirada fixa do agente halogenado com a finalidade de uniformizar o plano anestésico. A associação de anestesia locorregional durante a manutenção de anestesia inalatória diminui a necessidade de halogenado 14,15 . A anestesia peridural, com lidocaína, durante anestesia mantida com sevoflurano diminui a CAM deste anestésico em 50%.…”

Section: Discussionunclassified

“…Perioperative analgesia promoted by caudal epidural anesthesia allowed patients to be maintained under general anesthesia with a fixed expired concentration of halogenate in order to get a similar level of anesthesia. The association of local-regional anesthesia to inhalational anesthesia decreases the need for halogenates 14,15 . Epidural anesthesia with lidocaine during sevoflurane anesthesia decreases sevoflurane's MAC in 50%.…”

Section: Discussionmentioning

confidence: 99%

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Influência do óxido nitroso na velocidade de indução e de recuperação do halotano e do sevoflurano em pacientes pediátricos

Tardelli

Iwata

Amaral

et al. 2001

Rev. Bras. Anestesiol.

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Section: Discussionunclassified

Section: Discussionmentioning

confidence: 99%

Influência do óxido nitroso na velocidade de indução e de recuperação do halotano e do sevoflurano em pacientes pediátricos

Tardelli

Iwata

Amaral

et al. 2001

Rev. Bras. Anestesiol.

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“…Other basic science papers suggest the inhibition of G-protein-coupled receptors and the inflammatory response as possible contributors to the analgesia seen with lidocaine infusions (11). Lidocaine infusion may also reduce anesthetic requirements and MAC by 20% to 40% (12,13), with potential economic benefits.…”

Section: Discussionmentioning

confidence: 99%

Lidocaine Infusion as a Rescue Analgesic in the Perioperative Setting

Clarke

McConachie

Banner

2008

Pain Research and Management

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In the present case series, three patients for whom regional anesthesia may have been the optimum technique for controlling postoperative pain are discussed. However, due to prevailing circumstances, regional anesthesia could not be provided. An intravenous infusion of lidocaine at 4 mg/min was administered perioperatively as an alternative 'rescue' analgesic technique. This infusion rate, based on previous extensive pharmacokinetic studies, is widely considered to be safe. Postoperative pain was lower than expected for the type of surgery. Anecdotal experience suggests that hospital length of stay may also be reduced, with both patient and economic benefits.Key Words: Analgesia; Lidocaine; Postoperative pain Perfusion de lidocaïne comme analgésique de dernier ressort dans un contexte périopératoire Avec la présente série de cas, on décrit trois patients pour qui l'anesthésie régionale aurait pu être la technique optimale de soulagement de la douleur post-opératoire. Or, en raison des circonstances, l'anesthésie régionale n'a pas pu leur être offerte. En dernier ressort, une perfusion intraveineuse de lidocaïne leur a été administrée à raison de 4 mg/min comme solution de rechange en période périopératoire. Ce débit de perfusion, établi selon des études pharmacocinétiques antérieures approfondies, est largement considéré sécuritaire. La douleur post-opératoire a été moins intense que prévu compte tenu du type de chirurgie. L'expérience anecdotique donne à penser que le séjour hospitalier peut également être abrégé, ce qui est intéressant pour le patient et économiquement avantageux.

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“…33 It has been suggested that this analgesic effect of lidocaine may be important in its ability to decrease the requirement for inhalation anesthetics. 34 Ketorolac is a non-steroidal anti-inflammatory drug that has been used to inhibit the inflammatory response to surgical trauma and improve postoperative analgesia. 17 In addition, ketorolac was associated with decreased incidence of postoperative nausea and vomiting and provided an earlier discharge compared to patients receiving opioid drugs.…”

Section: Statisticsmentioning

confidence: 99%

Non-opioid analgesia improves pain relief and decreases sedation after gastric bypass surgery

Feld

Laurito

Beckerman

et al. 2003

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : Several non-opioid drugs have been shown to provide analgesia during and after surgery. We compared sevoflurane anesthesia with fentanyl analgesia to sevoflurane and non-opioid drug treatment for gastric bypass surgery and recovery.M Me et th ho od ds s: : Thirty obese patients (body mass index > 50 kg·m -2 ) undergoing gastric bypass were randomized to receive sevoflurane anesthesia with either fentanyl or a non-opioid regimen including ketorolac, clonidine, lidocaine, ketamine, magnesium sulfate, and methylprednisolone. Morphine use by patient-controlled analgesia (PCA) pump and pain score measured by visual analogue scale were determined in the postanesthesia care unit (PACU) and for the first 16 hr after surgery. Sedation was evaluated in the PACU. Investigators assessing patient outcomes were blinded to the study group.R Re es su ul lt ts s: : Fentanyl treated patients were more sedated in the PACU compared to the non-opioid group. Non-opioid treated patients required 5.2 ± 2.6 mg·hr -1 morphine by PCA during their stay in the PACU while patients anesthetized with fentanyl used 7.8 ± 3.3 mg·hr -1 (P < 0.05). Fentanyl and non-opioid treated patients showed no difference in pain score one or 16 hr after surgery.C Co on nc cl lu us si io on n: : Our results show that non-opioid analgesia produced pain relief and less sedation during recovery from gastric bypass surgery compared to fentanyl. Objectif : On reconnaît à certains médicaments non-opioïdes des Résultats : La sédation, notée à la SDR, était plus importante chez les patients traités au fentanyl, comparés à ceux traités avec un médicament non-opioïde. Les patients traités aux non-opioïdes ont demandé 5,2 ± 2,6 mg·h -1 de morphine en AAC pendant leur séjour en SDR tandis que les patients anesthésiés au fentanyl en ont utilisé 7,8 ± 3,3 mg·h -1 (P < 0,05). Les scores de douleurs des patients des deux groupes n'ont présenté aucune différence, une ou 16 h après l'opération. Conclusion : L'analgésie avec des non opioïdes, comparé au fentanyl, a mieux soulagé la douleur et provoqué moins de sédation pendant la récupération qui suit un pontage gastrique.HE body mass index (BMI), calculated as the weight in kilograms divided by the height in metres squared, has been used in clinical and epidemiological studies as a predictor of health risk. 1 A BMI of 25 kg·m -2 is considered normal, > 30 kg·m -2 obese, > 35 kg·m -2 morbidly obese and > 55 kg·m -2 super morbidly obese. Respiratory problems are associated with morbid obesity, including obstructive apnea during sleep, decreased functional residual capacity and lung compliance and increased work of breathing. 2,3 Obese patients may be sensitive to the respiratory depressant effect of opioid analgesic drugs and more likely to require postoperative ventilation to avoid hypoxic episodes.

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Effects of Lidocaine on the Anesthetic Requirements for Nitrous Oxide and Halothane

Cited by 143 publications

References 0 publications

Influência do óxido nitroso na velocidade de indução e de recuperação do halotano e do sevoflurano em pacientes pediátricos

Influência do óxido nitroso na velocidade de indução e de recuperação do halotano e do sevoflurano em pacientes pediátricos

Lidocaine Infusion as a Rescue Analgesic in the Perioperative Setting

Non-opioid analgesia improves pain relief and decreases sedation after gastric bypass surgery

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