Effects of lichen homogenates, mixtures of extracted substances and secondary metabolites on macromycetes – a critical review

Furmanek, Łukasz; Czarnota, Paweł; Seaward, M. R. D.

doi:10.1016/j.sajb.2022.06.048

Cited by 6 publications

(19 citation statements)

References 66 publications

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“…Firstly, we performed a literature search on the 817 cited plants and classified them on their use: plants for human health (87.1%, 712), plants for preparation of liqueurs (11.5%, 94), and plants for veterinary use (1.4%, 11) (Figure 2). The cited officinal natural sources include one lichen (Cetraria islandica L.) which is now an emerging organism in the drug development field [40] We particularly focused on the 56 species specifically mentioned by informants for medicinal uses and calculated relative frequency citation (0 < RFC < 1), useful to identify the frequency of use and the local importance of each species. The RFC index is given by the frequency of citation (FC, the number of informants mentioning the use of the species) divided by the total number of informants participating in the survey (N), without considering the use categories [41].…”

Section: Plant Species Cited By Informantsmentioning

confidence: 99%

Walking around the Autonomous Province of Trento (Italy): An Ethnobotanical Investigation

Cavalloro

Cuna

Quai

et al. 2022

Plants

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The Trentino-South Tyrol region is a special statute region of northeastern Italy. This territory is of particular interest for its morphology, flourishing vegetation, and history, having been a meeting area among different civilizations. Hence, Trentino is characterized by an ethnic plurality and a rich ethnobotanical knowledge, even if the available information is fragmentary, widely dispersed, and often guarded in oral popular culture. To fill this gap, in the present work 200 subjects were interviewed using an ethnobotanical survey. The resulting 817 citations referred to 64 native species, used either for human or animal health or for domestic purposes. As a second step, for each plant exploited for medicinal purposes, local importance was evaluated by calculating their relative frequency of citation. Moreover, the main traditional preparations were discussed. Among them, the most cited and exploited ones are Achillea millefolium, Arnica montana, Hypericum perforatum, Malva sylvestris, Pinus mugo, and Satureja montana, for which a deeper analysis has been performed. Lastly, the ethnobotanical knowledge of the plants growing in this territory will add a piece to the mosaic of traditional medicine in Italy and may lay the foundation for a nature-aided drug discovery process.

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Section: Plant Species Cited By Informantsmentioning

confidence: 99%

Walking around the Autonomous Province of Trento (Italy): An Ethnobotanical Investigation

Cavalloro

Cuna

Quai

et al. 2022

Plants

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“…7, 16, 18, 33, Os riscos toxicológicos a saúde humana podem advir da exposição ambiental ou ocupacional, sendo considerada uma importante, uma vez que este composto pode ser rapidamente absorvida por via inalatória, oral ou cutânea. 14,18,33,34,35,36 C. TOXICOLOGIA DA ANILINA A anilina é um composto que apresenta absorção sistêmica rápida quando ocorrem exposições por inalação, cutânea e ingestão. Em contato cutâneo, podem ocorrer absorção em quantidades que favoreçam a intoxicação sistêmica, além dos riscos de contaminação secundária aos socorristas.…”

Section: B Aplicação Da Anilina E Seus Derivados Importantesunclassified

Anilina

Kramer

Júnior

Sousa³

et al. 2023

Saúde e meio ambient.: rev. interdisciplin.

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A anilina é obtida a partir do nitrobenzol e pertence ao grupo de benzoaminas (aminas aromáticas). É um importante precursor de produtos utilizados no setor agropecuário, corantes sintéticos, antioxidantes, espumas de poliuretano, setor de alimentos e têxtil. Apesar desta diversidade, a anilina e seus derivados podem incorrer em riscos à saúde humana e ambiental. Neste sentido, objetivou-se discorrer através de uma revisão os aspectos importantes inerentes a anilina. Este estudo caracterizou-se como um estudo de revisão, sendo para tanto, utilizados como descritores: anilina, corante, aditivo, química, toxidade e aplicação. Sendo considerados como fontes bibliográficas, artigos, livros e fichas técnicas. A partir dos dados coletados, observou-se como principais aplicações da anilina, a produção de diisocianato-poliuretano, azobenzenos, quinonas, anilidas e sulfonamidas, aplicados nos setores automotivos, construção civil, farmacêuticos, alimentos, inseticidas e corantes. Quanto aos aspectos toxicológicos, principalmente ocupacionais, verificou-se como principais vias de exposição a inalatória, ingestão e cutânea, com rápida absorção sistêmica. Na sequência, o metabolismo da anilina gera compostos que afetam a hemoglobina e hemácias acarretando em cianose dos tecidos, gerando como sintomas da intoxicação: náusea, emêse, desconforto abdominal, diarreia, tonturas e cefaleia. Acerca dos riscos ambientais, observou-se a ocorrência de azocompostos, corantes, principalmente no setor têxtil, com riscos a fauna. Portanto, está revisão possibilitou apresentar uma revisão sobre a anilina, englobando-se seus derivados, suas aplicações e riscos toxicológicos/ambientais. Possibilitando colaborar com o debate acadêmico acerca de sua importância industrial, bem como apresentar os riscos à saúde humana e ambiental, devendo-se haver controles de exposição ocupacional e descarte adequado de efluentes, para mitigação destes riscos. Palavras-chave: Benzoaminas. Toxicidade. Anilina. Aplicação. Ambiental.

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“…Most of these secondary metabolites are not synthesized by other organisms, even by the fungal partner cultured outside the symbiosis. Although about 1000 secondary metabolites have been isolated from lichens so far (Elix, 2014;Furmanek et al, 2022b), the number of those tested for their biological activities is relatively small. However, the number of studies on the bioactivities of lichen-derived secondary metabolites has increased significantly in recent years (Adenubi et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…It is commonly known as "horsehair lichen" (Smith, 2009). Researchers reported antibacterial (Karagoz et al, 2018;Tas et al, 2019;Yılmaz Sarıözlü et al, 2016), antifungal (Furmanek et al, 2022a(Furmanek et al, , 2022b(Furmanek et al, , 2022c, anti-cancer (Goncu et al, 2020;Ozturk et al, 2021;Tripathi et al, 2022;Varol, 2018), antioxidant and antigenotoxic (Tas et al, 2017;Tufan-Cetin & Cetin, 2021;Turkez et al, 2014) effects of BC.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of carbonic anhydrase and cholinesterase enzymes by acetone extract of Bryoria capillaris (Ach.) Brodo & D.Hawksw.

KARAGÖZ,

UZUN,

ALPARSLAN

et al. 2024

International Journal of Secondary Metabolite

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In traditional medicine, people commonly consume Bryoria capillaris (BC) as flour and tea, particularly in Northeast Anatolia, where it is one of the most prevalent lichen species. This study aimed to obtain an acetone extract of BC and investigate its inhibitory effects on carbonic anhydrase (CA) I, CA II, acetylcholine esterase (AChE), and butyrylcholine esterase (BChE) enzymes. We determined IC50 values of BC for each enzyme to measure the level of inhibition. The IC50 values for CA I and CA II were 8.77 μg/mL and 7.56 μg/mL, respectively. Acetazolamide, a specific CA I and II inhibitor, had IC50 values of 1.65 and 0.016 μg/mL, respectively. The IC50 values of BC for AChE and BChE were 7.96 and 8.58 μg/mL, respectively. Galantamine had IC50 values of 4.68 and 16.07 μg/mL for AChE and BChE, respectively. These results indicate that BC extract has a high potential to provide new drug candidates for all the tested enzymes, particularly for BChE.

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Effects of lichen homogenates, mixtures of extracted substances and secondary metabolites on macromycetes – a critical review

Cited by 6 publications

References 66 publications

Walking around the Autonomous Province of Trento (Italy): An Ethnobotanical Investigation

Walking around the Autonomous Province of Trento (Italy): An Ethnobotanical Investigation

Anilina

Inhibition of carbonic anhydrase and cholinesterase enzymes by acetone extract of Bryoria capillaris (Ach.) Brodo & D.Hawksw.

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