Effects of levamisole on the immune response and disease resistance of Clarias fuscus

Li, Guifeng; Yungui, Guo; Zhao, Dianhui; Qian, Ping; Sun, Jijia; Xiao, Cuie; Liang, Lanqing; Wang, Haifang

doi:10.1016/j.aquaculture.2005.10.001

Cited by 35 publications

(44 citation statements)

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“…Feeds supplemented with levamisole enhance phagocytosis and natural killing cell activity in gilthead seabream (Sparus aurata) (Mulero et al 1998) and lysozyme activity in common carp (Cyprinus carpio) (Gopalakannan and Arul 2006) and whitespotted clarias (Clarias fuscus) (Li et al 2006a), and reduce mortality in fish infected with pathogenic bacteria (Gopalakannan and Arul 2006;Li et al 2006a). Moreover, dietary supplementation with levamisole enhances the growth of common carp juveniles (Gopalakannan and Arul 2006).…”

Section: Introductionmentioning

confidence: 99%

Impact of brewer's yeast extract and levamisole in diets with vegetable oils on the growth, chemical composition, and immunological and biochemical blood parameters of pikeperch (Sander lucioperca)

Kowalska¹,

Zakęś²,

Siwicki³

et al. 2015

CZECH J ANIM SCI

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The impact of applying NuPro® (40 g/kg feed) and levamisole (300 mg/kg feed) in European pikeperch (Sander lucioperca) diets with vegetable oils on growth, immunological, hematological, and blood chemical parameters was assayed. The fish were fed the feed containing sunflower and linseed oils (48 and 21 g/kg feed) (group VO) or this feed with levamisole (group VOL) or NuPro ® (group VON). The fourth group was fed the feed with fish oil added in the amount of 69 g/kg feed (group FO). The pikeperch were reared for 56 days. Feeding the fish feed supplemented with levamisole or NuPro ® increased the immunological responses of the phagocytes and lymphocytes, lysozyme activity, and total gamma-globulin levels. The feed supplemented with NuPro ® resulted in decreased aspartate and alanine aminotransferase and alkaline phosphatase activity. Vegetable oils in the feed were linked to increased contents of linoleic acid in fish bodies. The quantity of eicosapentaenoic and docosahexaenoic acids was significantly the highest in group FO. The immunological index obtained in group VON indicated that the diet supplemented with brewer's yeast extract (NuPro ® ) was the most advantageous when feeding juvenile pikeperch feeds with vegetable oils.

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Section: Introductionmentioning

confidence: 99%

Impact of brewer's yeast extract and levamisole in diets with vegetable oils on the growth, chemical composition, and immunological and biochemical blood parameters of pikeperch (Sander lucioperca)

Kowalska¹,

Zakęś²,

Siwicki³

et al. 2015

CZECH J ANIM SCI

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“…Similar findings were reported by Misra et al & Mulero et al [31][32][33] for gilthead seabream stating that the dietary intake of levamisole had a significant impact on the size and weight of fish throughout the experiment when compared with control. In a study by Li et al [34] on juvenile hybrid striped bass, low doses of levamisole (<500 mg kg -1 of diet) significantly enhanced feed efficiency and growth by approximately 10% after 3 weeks of feeding as compared to fish fed on basal diets. In the present study 37.86 % increase in growth has been observed by feeding the fish on levamisole (@ 250 mg kg -1 ) supplemented diets in comparison to controls.…”

Section: Discussionmentioning

confidence: 95%

“…Many studies have reported capability of levamisole in enhancing immune responses and/or reducing losses from bacteria and/or parasitic infections in different species such as carp [8,10], gilthead sea bream [33], rainbow trout [14,36], Atlantic salmon [37,38], rohu [39,40,11], hybrid striped bass [34], catfish [12].…”

Section: Discussionmentioning

confidence: 99%

“…Baba et al [8] also reported that survival rate after challenging the fish with Aeromonas hydrophila was higher in common carp treated with levamisole. Levamisole has also been found to be a possible modulator of the immune response by eliciting resistance after challenge trial in Cyprinus carpio [46,8] Oncohrynchus mykiss [42], Sparus aurata [33], Clarias batrachus [9], Morone chrysops×Morone saxatilis [34].…”

Section: Discussionmentioning

confidence: 99%

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Immunostimulating and Growth Promoting Activity of Dietary Levamisole on Cirrhinus mrigala Fingerlings

Bhatnagar¹

2016

JAMB

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The effects of supplementing diets with levamisole on growth, immune response and resistance against pathogenic Aeromonas hydrophila were determined. Fish were assigned to three treatments with different level of levamisole (125, 250 and 500 mg kg¯¹ diet) and the control diet was prepared without levamisole. Cirrhinus mrigala were fed at 4% of their body mass for 60 days. Growth performance, enzyme activities and immunological parameters were analyzed among groups. The total erythrocyte count, total leucocyte count, phagocytic activity and NBT reduction were significantly (P<0.05) enhanced in levamisole treated group when compared to control. The relative percentage survival, A. hydrophila post-challenge was significantly higher in fishes fed on 250 mg kg¯¹ of levamisole supplemented diet. The same dose also resulted in significantly high specific growth rate (SGR), feed conversion ratio (FCR), apparent protein digestibility (APD) and elevated intestinal enzyme activities compared to other groups. Thus, administration of 250 mg of levamisole kg¯¹ diet is recommended for enhancement of immunity, growth and survival of C. mrigala hence acting as a potent immunostimulant agent

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“…Levamisole (LEV), an antihelminthic and immunomodulator drug, is widely used in veterinary medicine as an antiparasitic. In fish, Li et al (2006) observed that oral administration of LEV stimulates nonspecific defense mechanisms and the specific immune response against Acinetobacter iwoffii in Clarias fuscus. Findlay et al (2000) showed that Atlantic salmon treated with LEV bath enhances the resistance to amoebic gill disease and stimulate the nonspecific immune system.…”

Section: Introductionmentioning

confidence: 99%

Influence of dexamethasone and levamisole on macrophage recruitment, giant cell formation and blood parameters in the tropical fish Piaractus mesopotamicus

Petrillo¹,

Claudiano²,

Yunis‐Aguinaga³

et al. 2017

Biosci. J.

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ABSTRACT:The aim of this study was to evaluate the effect of parenteral administration of dexamethasone and levamisole on the accumulation of macrophages and formation of giant cells in chronic inflammation by foreign body and blood parameters in pacu (Piaractus mesopotamicus). It was used 50 mg/kg of levamisole and 2.0 mg/kg of dexamethasone and the combination of both drugs. Coverslips were implanted under the skin. After 2, 7, and 15 days postimplantation (DPI), fish were anesthetized for removal of coverslips and the number of macrophages and giant cells were count. It was also collected blood from the caudal vessel to evaluate: red blood cell count, hematocrit, hemoglobin concentration, leukocytes count, thrombocytes count, MCV, and MCHC. We observed that dexamethasone affects negatively the formation of giant cells in the chronic inflammation for foreign body. Levamisole, despite being immunostimulatory in several species, showed limited action. However, it was enough to counteract the effect of dexamethasone; the association of the drugs did not interfere significantly in erythrocyte and leukocyte number in most of the treatments and times studied. In dexamethasone group there was a reduction in the number of erythrocytes and hemoglobin associated with increased mean corpuscular volume, suggesting slight macrocytic anemia. At 15 DPI, most groups showed the recovery of hematologic response. As in mammals, dexamethasone affects negatively the inflammatory response. Levamisole showed little effect by itself. However, in some parameters the association of both drugs causes similar response to control and naïve groups, showing the antagonistic effect of these drugs.

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Effects of levamisole on the immune response and disease resistance of Clarias fuscus

Cited by 35 publications

References 10 publications

Impact of brewer's yeast extract and levamisole in diets with vegetable oils on the growth, chemical composition, and immunological and biochemical blood parameters of pikeperch (Sander lucioperca)

Impact of brewer's yeast extract and levamisole in diets with vegetable oils on the growth, chemical composition, and immunological and biochemical blood parameters of pikeperch (Sander lucioperca)

Immunostimulating and Growth Promoting Activity of Dietary Levamisole on Cirrhinus mrigala Fingerlings

Influence of dexamethasone and levamisole on macrophage recruitment, giant cell formation and blood parameters in the tropical fish Piaractus mesopotamicus

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