Effects of lead acetate on guinea pig—Cochear microphonics, action potential, and motor nerve conduction velocity

Yamamura, Kohtaroh; Maehara, Naoki; Terayama, Kazuyuki; Ueno, Nobumasa; Kohyama, Akio; Sawada, Yukihiro; Kishi, Reiko

doi:10.1007/bf01608588

Cited by 8 publications

(2 citation statements)

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“…We have already demonstrated that exposure to 80 dB sound or the injection of 80 mg lead acetate alone did not induce changes in inner ear function [2,7,21,28,29]. In this report, concomitant effects of relatively high levels of lead acetate and relatively low levels of sound exposure were able to induce significant changes in inner ear function, especially in CM output voltage.…”

Section: Discussionmentioning

confidence: 60%

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Combined effects of acute lead acetate exposure and tone exposure of the guinea pig cochlea

Hotta

Sugisawa

Matsui

et al. 1996

Eur Arch Otorhinolaryngol

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Lead acetate exposure to humans can induce various disorders of the cranial nerves. Although vertigo and sensorineural deafness have been reported in lead workers, the dose effects of lead acetate on the cochlea and eighth cranial nerve are not well documented. We investigated the effects of lead acetate on the male albino Hartley guinea pig cochlea by measuring cochlear microphonics (CM), whole nerve action potential (AP), endocochlear potential (EP) and K+ ion concentration of the endolymph. Animals were given lead acetate by intraperitoneal injection as 20 mg/week for 4 consecutive weeks. A total dose < 80 mg did not induce electrophysiological changes in the cochlea. However, the AP output voltage (N1) decreased if the 80 mg lead acetate treatment was followed by an 80 dB tone exposure at 6 kHz during 24 h. A change was observed in CM and EP but not K+ ion concentration in the scala media.

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Section: Discussionmentioning

confidence: 60%

“…A difference in AP threshold was not observed [27]. Yamamura et al [28] reported the effects of lead acetate on the inner ear, using measurements of CM and AR and found only a change in AP maximum output.…”

Section: Discussionmentioning

confidence: 99%