Effects of lanthanum, cerium, and neodymium on the nuclei and mitochondria of hepatocytes: Accumulation and oxidative damage

Huang, Peili; Li, Jianxin; Zhang, Shuhua; Chen, Chunxia; Han, Ying; Liu, Na; Xiao, Yang; Wang, Hui; Zhang, Man; Yu, Qiuhong; Liu, Yuting; Wang, Wei

doi:10.1016/j.etap.2010.09.001

Cited by 91 publications

(45 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Until now, only a few studies have been carried out to investigate the influence of ECAP on corrosion behaviors of magnesium and its alloys [12,13]. The limited literatures present that these ECAP procedures endow some magnesium alloys with higher corrosion resistance and better mechanical properties [8,9,14]. However, the corrosion results in NaCl solution cannot be used to perfectly predict biodegradation behaviors of magnesium alloys in the physiological environment.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the magnesium alloy containing Al, Cd and heavy metals is not appropriate for clinical application from the medical aspect [15]. The ZE41A magnesium alloy with low rare-earth (RE) content is suitable to act a biodegradable material since some RE elements are proven to be tolerated by the human body [14,16]. Our previous work showed that the ZE41A alloy after multi-pass ECAP consists of UFG Mg matrix and homogeneously dispersed second-phase particles, which contribute to better mechanical properties at room temperature and the higher corrosion resistance in NaCl solutions [17,18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biodegradable Behaviors of Ultrafine-Grained ZE41A Magnesium Alloy in DMEM Solution

Jiang

Zhang

et al. 2015

Metals

View full text Add to dashboard Cite

Abstract:The main limitation to the clinical application of magnesium alloys is their too-fast degradation rate in the physiological environment. Bio-corrosion behaviors of the ZE41A magnesium alloy processed by multi-pass equal channel angular pressing (ECAP) were investigated in Dulbecco's Modified Eagle Medium (DMEM) solution, in order to tailor the effect of grain ultrafining on the biodegradation rate of the alloy implant. Hydrogen evolution tests indicated that a large number of ECAP passes decreased the stable corrosion rate of the alloy after the initial incubation period. Potentiodynamic polarization curves showed that more ECAP passes made the corrosion potential nobler and the corrosion tendency lower. Corroded surfaces of the ECAPed alloy indicated a higher resistance toward localized corrosion due to the homogeneous redistribution of broken second phases on the ultrafine-grained Mg matrix. It suggests that grain ultrafining can decrease the biodegradable rate of the magnesium alloy-containing rare-earth elements and tailor the lifetime of the biodegradable material.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biodegradable Behaviors of Ultrafine-Grained ZE41A Magnesium Alloy in DMEM Solution

Jiang

Zhang

et al. 2015

Metals

View full text Add to dashboard Cite

show abstract

“…As Neodymium level of exposure increased, a corresponding increase of Neodymium occurred in the tissues. 6 The effect of Neodymium on distributions and accumulations in various tissues, especially in the liver, lung, bone and kidney of people and animals has been reported, [6][7][8][9][10] but few papers have focused on the interactions of Neodymium with serum albumin through multi-spectroscopic techniques.…”

Section: Introductionmentioning

confidence: 99%

Study on the Interaction of Nd³⁺ with Human Serum Albumin at Molecular Level

Yuan

Shen

Liu

et al. 2011

J Chinese Chemical Soc

View full text Add to dashboard Cite

Neodymium is applied widely in agriculture to improve crop nutrition and incidentally in fertilizers, yet little is known of its effect on the biological function of human serum albumin (HSA). The interaction of Nd 3+ to HSA has been investigated mainly by fluorescence spectra, UV-vis absorption spectra and circular dichroism (CD) under simulative physiological conditions. Fluorescence data revealed that the quenching mechanism of HSA by Nd 3+ was a static quenching process and the binding constant is 5.71 × 10 4 L mol -1 and the number of binding sites is 1 at 292 K. The thermodynamic parameters (DH 0 = -20.79 kJ mol -1 , DG 0 = -26.58 kJ mol -1 , and DS 0 = 19.85 J mol -1 K -1 ) indicate that electrostatic effect between the protein and Nd 3+ is the main binding force. The distance r = 2.91 nm between donor (HSA) and acceptor (Nd 3+ ) was obtained according to Förster's nonradiative energy transfer. In addition, UV-vis, CD and synchronous fluorescence results showed that the addition of Nd 3+ changed the conformation of HSA.

show abstract

“…Accordingly, it has been reported that some lanthanides induce mitochondrial dysfunction that could be the cause of this cytotoxic effect. [74,[76][77] It should be noticed that Gd did not show any toxic effect at these concentrations. Likewise, for 1400 µM an important difference between La vs Gd results was also observed in viability with Acridine Orange dye.…”

Section: Threshold Values Of Cyto-genototicity Values Of Individual Ionsmentioning

confidence: 80%

Cellular response to rare earth mixtures (La and Gd) as components of degradable Mg alloys for medical applications

Grillo

Álvarez

Mele

2014

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Effects of lanthanum, cerium, and neodymium on the nuclei and mitochondria of hepatocytes: Accumulation and oxidative damage

Cited by 91 publications

References 25 publications

Biodegradable Behaviors of Ultrafine-Grained ZE41A Magnesium Alloy in DMEM Solution

Biodegradable Behaviors of Ultrafine-Grained ZE41A Magnesium Alloy in DMEM Solution

Study on the Interaction of Nd³⁺ with Human Serum Albumin at Molecular Level

Cellular response to rare earth mixtures (La and Gd) as components of degradable Mg alloys for medical applications

Contact Info

Product

Resources

About

Effects of lanthanum, cerium, and neodymium on the nuclei and mitochondria of hepatocytes: Accumulation and oxidative damage

Cited by 91 publications

References 25 publications

Biodegradable Behaviors of Ultrafine-Grained ZE41A Magnesium Alloy in DMEM Solution

Biodegradable Behaviors of Ultrafine-Grained ZE41A Magnesium Alloy in DMEM Solution

Study on the Interaction of Nd3+ with Human Serum Albumin at Molecular Level

Cellular response to rare earth mixtures (La and Gd) as components of degradable Mg alloys for medical applications

Contact Info

Product

Resources

About

Study on the Interaction of Nd³⁺ with Human Serum Albumin at Molecular Level