Effects of Lantana camara (Verbenaceae) on general reproductive performance and teratology in rats

Mello, Fernanda Bastos de; Jacobus, Daniela; Carvalho, Kelly Cristina Silva de; Mello, João Roberto Braga de

doi:10.1016/j.toxicon.2004.12.004

Cited by 52 publications

(42 citation statements)

References 10 publications

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“…At higher doses (500 and 1000 mg/ kg), fecal output was almost completely stopped. Mello et al (2005) investigated the effects of the hydroalcoholic extract of the leaves of L. camara var. aculeate on reproduction.…”

Section: Anti-motility Activitymentioning

confidence: 99%

Genus Lantana: chemical aspects and biological activities

Sousa¹,

Costa²

2012

Rev. bras. farmacogn.

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Species of the genus Lantana, belonging to the family Verbenaceae, is among the various species studied scientifically. These species are mainly native to the tropical and subtropical regions of the Americas. Currently, they are present in various countries, where they are often grown as ornamental plants. For decades, species of Lantana have been of great interest for phytochemical, biological and pharmacological studies, which have been recently intensified. The components isolated from different species of Lantana cited in the literature constitute the focus of this review. Information ethnopharmacology of Lantana, as well as the activities of their different phytochemicals are discussed. In this review, it was observed that the genus Lantana has been widely studied in relation to its phytochemical components and terpenoids, flavonoids and phenylpropanoids are the more common secondary metabolites in Lantana. All these aspects, considered in this review, allow an evaluation of the ethnopharmacological potential of Lantana for the utilization of the large biomass of these plants.

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Section: Anti-motility Activitymentioning

confidence: 99%

Genus Lantana: chemical aspects and biological activities

Sousa¹,

Costa²

2012

Rev. bras. farmacogn.

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“…O período de pré-implantação compreende o período de 0-16 dias de gestação em humanos (Rang et al, 2004), na qual ocorre a diferenciação celular e conseqüente formação do blastocisto (Mello, 2000). A fase que antecede a implantação, fase pré-implantação, representa um período de autonomia relativa do embrião.…”

Section: Plantas Medicinais Com Potencial Embriotóxico Teratogênico unclassified

“…Estudos realizados com ratas wistar prenhas mostraram que arruda (Gonzales et al, 2006), barbatimão (Vitral et al, 1987), cambará (Mello et al, 2005), chapéu-de-couro (Toledo et al, 2004b), falso boldo (Almeida & Lemonica, 2000), vidreira (Chan & NG, 1995), Rhazya stricta (Rasheed et al, 1997) ... continuação TABELA 1. Relação de plantas embriotóxicas, teratogênicas e abortivas comumente utilizadas pela população.…”

Section: Plantas Medicinais Com Potencial Embriotóxico Teratogênico unclassified

“…A partir de então, acredita-se que o efeito do barbatimão ocorra através de alterações da zona basal da placenta, acarretando a morte embrionária e atrofia do corpo lúteo (Vitral et al, 1987). Mello et al (2005) afirmam que o cambará (Lantana camara) apresenta atividade embriotóxica. É utilizado para fins antipiréticos, antimicrobianos e antimutagênicos (Seawrigth, 1965;Sharma et al, 1988).…”

Section: Plantas Medicinais Com Potencial Embriotóxico Teratogênico unclassified

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Efeito embriotóxico, teratogênico e abortivo de plantas medicinais

Rodrigues¹,

Meireles²,

Lima³

et al. 2011

Rev. bras. plantas med.

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RESUMO: O uso milenar de plantas medicinais mostrou ao longo dos anos, que determinadas plantas apresentam substâncias potencialmente perigosas. Do ponto de vista científico, algumas pesquisas mostraram que muitas dessas plantas possuem substâncias agressivas e por essa razão devem ser utilizadas com cuidado, respeitando seus riscos toxicológicos. Os efeitos mais preocupantes do uso indiscriminado de plantas medicinais são embriotóxico, teratogênico e abortivo, uma vez, que os constituintes da planta podem atravessar a placenta, chegar ao feto e gerar um desses efeitos. Este estudo objetiva fornecer uma listagem das principais plantas medicinais que tenham efeitos embriotóxicos, teratogênicos e abortivos comprovados, conhecendo as partes da planta utilizadas e seus respectivos nomes científicos, com a finalidade de alertar gestantes quanto aos riscos de seu uso. Realizou-se buscas nas bases eletrônicas de dados SciELO, PubMed, MEDLINE, LILACS, CAPES e Google acadêmico. Nos resultados encontrados, plantas como Arnica (Arnica montana), Artemísia (Artemisia vulgaris), Arruda (Ruta chalepensis/ Ruta graveolens), Barbatimão (Stryphnodendron polyphyllum), Boldo (Vernonia condensata) dentre outras, podem vir a gerar um desses efeitos. A partir deste estudo comprova-se que para a maioria das plantas medicinais não há dados a respeito da segurança de seu uso durante a gravidez.Palavras-chave: plantas medicinais, gestação, teratogênico, embriotóxico, abortivo ABSTRACT: Embryotoxic, teratogenic and abortive effects of medicinal plants. The ancient use of medicinal plants has shown over the years that certain plants have potentially dangerous substances. From a scientific point of view, some studies have shown that many of these plants contain aggressive substances and therefore should be used with caution, respecting their toxicological risks. The most important effects of the indiscriminate use of medicinal plants are embryotoxic, teratogenic and abortifacient since the plant constituents can cross the placenta, reaching the fetus and leading to one of these effects. This study aimed to provide a list of the major medicinal plants that have proven embryotoxic, teratogenic and abortifacient effects, including the used plant parts and their respective scientific names, in order to warn pregnant women about the risks of its use. Searches were carried out in the electronic databases SciELO, PubMed, MEDLINE, LILACS, CAPES and Google Scholar. Results indicated that plants such as mountain arnica (Arnica montana), mugwort (Artemisia vulgaris), fringed rue (Ruta chalepensis / Ruta graveolens), "Barbatimão" (Stryphnodendron polyphyllum) and "Boldo" (Vernonia condensata) are likely to generate such an effect. This study shows that for most medicinal plants there are not data regarding the safety of their use during pregnancy.

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“…A great number of experimental studies had indicated that the prenatal administration of plants can result in structural and functional suppression of the growth, fetal anomaly and death (Lemonica and Alvarenga 1994, Damasceno and Lemonica 1999, Damasceno et al 2002a, Mello et al 2005, Dallaqua et al 2013). However, several plants had already been studied during pregnancy, and showed no deleterious effects (Monteiro et al 2001, Rudge et al 2007, Volpato et al 2011.…”

Section: Introductionmentioning

confidence: 99%

Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats

Volpato

Francia-Farje

Damasceno

et al. 2015

An. Acad. Bras. Ciênc.

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Citrus aurantium L., commonly known as bitter orange, is widely used in folk medicine, but there is little data in the literature about the effects on pregnancy. The aim of the present study was to evaluate the influence of essential oil obtained from fruits of Citrus aurantium on the maternal reproductive outcome and fetal anomaly incidence in rats. Pregnant Wistar rats were randomized into four groups (n minimum = 12 animals/group): G1 = control, G2 to G4 = treated with essential oil from C. aurantium at dose 125, 250 and 500 mg/kg, respectively. Rats were orally treated, by gavage, with plant essential oil or vehicle during pre-implantation and organogenic period (gestational day 0-14). On gestational day 20 the rats were anaesthetized and the gravid uterus was weighed with its contents and the fetuses were analyzed. Results showed that the treated group with 500 mg/kg presented decreased placental weights and placental index, although the treatment with bitter orange essential oil did not show any alteration in maternal reproductive performance, toxicological effect, changes in ossification sites, and malformation index. In conclusion, the treatment of Citrus aurantium essential oil was not teratogenic and did not alter the maternal reproductive outcome.

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Effects of Lantana camara (Verbenaceae) on general reproductive performance and teratology in rats

Cited by 52 publications

References 10 publications

Genus Lantana: chemical aspects and biological activities

Genus Lantana: chemical aspects and biological activities

Efeito embriotóxico, teratogênico e abortivo de plantas medicinais

Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats

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