Efeito embriotóxico, teratogênico e abortivo de plantas medicinais

Rodrigues, Hector Galdino; Meireles, C.G.; Lima, Jacicarlos; Toledo, G.P.; Cardoso, J.L.; Gomes, Simone Loiola

doi:10.1590/s1516-05722011000300016

Cited by 52 publications

(54 citation statements)

References 26 publications

(25 reference statements)

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“…Despite the therapeutic advantages of medicinal plants, their potential toxicity is not recognized by the general public or by many professional groups of traditional medicine (SOETAN; AIYELAAGBE, 2009). Many plant species commonly considered medicinal can contain potentially dangerous substances (RODRIGUES et al, 2011;MELO-REIS et al, 2011). Recent research studies conducted in vitro and in vivo revealed that many plants used as food or in traditional medicine have cytotoxic and genotoxic effects (SEHGAL et al, 2006;DALLA NORA et al, 2010;CARDOSO et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Jatropha curcas L. latex in Allium cepa test

Ciappina¹,

Ferreira²,

Pereira³

et al. 2017

Biosci. J.

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ABSTRACT:The latex obtained from Jatropha curcas (physic nut) is used in traditional medicine to treat a variety of disturbs, including burns, hemorrhoids, ringworm and ulcers. Phytochemical analyses have shown that J. curcas latex contains natural compounds with therapeutic potential. In this study, the toxicity, cytotoxicity and genotoxicity effects of J. curcas latex on the root cells of Allium cepa were examined. Onion seeds and bulbs were exposed to seven different concentrations of latex and then the roots were submitted to macro and microscopic analyses. Water and sodium azide were used as negative and positive controls, respectively. The analysis of root growth showed that J. curcas crude latex or 50% diluted is highly toxic. Cytogenetic results showed that the mitotic index of the onion roots submitted to latex treatment decreased significantly compared to the negative control, which suggests that the latex is cytotoxic. High incidence of chromosome aberrations in the cells treated with J. curcas latex was observed too, indicating that the latex also presents genotoxic effect. The analyses presented in this report suggest the toxic, cytotoxic and genotoxic effects of J. curcas latex. Then, the indiscriminate use of J. curcas latex in folk medicine could bring risk to human health.

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Section: Introductionmentioning

confidence: 99%

Toxicity of Jatropha curcas L. latex in Allium cepa test

Ciappina¹,

Ferreira²,

Pereira³

et al. 2017

Biosci. J.

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“…Despite the therapeutic advantages of medicinal plants, their potential toxicity has not been recognized by the general public or by professional groups of traditional medicine (Soetan and Aiyelaagbe, 2009), and many plant species commonly considered medicinal can contain potentially dangerous substances (Rodrigues et al, 2011). Recent research studies conducted in vitro and in vivo assay have revealed that many plants used as food or in traditional medicine have cytotoxic and genotoxic effects (Sehgal et al, 2006;Dalla Nora et al, 2010;Luz et al, 2012;Ping et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytotoxicity and genotoxicity of Hancornia speciosa latex in Allium cepa root model

et al. 2016

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The latex obtained from Hancornia speciosa Gomes (Mangabeira tree) is widely used in traditional medicine to treat a variety of diseases, including diarrhea, ulcer, gastritis, tuberculosis, acne and warts. In this study, the cytotoxicity and genotoxicity effects of H. speciosa latex on the root meristem cells of Allium cepa were examined. Onion bulbs were exposed to different concentrations of latex and then submitted to microscopic analysis using Giemsa stain. Water was used as a negative control and sodium azide as a positive control. The results showed that, under the testing conditions, the mitotic index (MI) of the onion roots submitted to latex treatment did not differ significantly from the negative control, which suggests that the latex is not cytotoxic. Low incidence of chromosome aberrations in the cells treated with H. speciosa latex was also observed, indicating that the latex does not have genotoxic effect either. The MI and the chromosome aberration frequency responded to the latex concentration, requiring more studies to evaluate the dosage effect on genotoxicity. The results indicate that in tested concentrations H. speciosa latex is probably not harmful to human health and may be potentially used in medicine.Keywords: Cerrado, popular medicine, mutagenesis. Avaliação da citotoxicidade e genotoxicidade do látex de Hancornia speciosa usando o modelo da raiz de Allium cepaResumo O látex obtido de Hancornia speciosa é amplamente utilizado na medicina popular para tratar uma variedade de doenças, tais como: diarreia, úlcera, gastrite, tuberculose, acne e verrugas. Nesse estudo, foram avaliados os efeitos citotóxicos e genotóxicos do látex de H. speciosa sobre as células meristemáticas das raízes de Allium cepa. Os bulbos das cebolas foram expostos a diferentes concentrações de látex e depois submetidos à analise microscópica usando o corante Giemsa. A água foi usada como controle negativo e a ázida sódica como controle positivo. Os resultados mostraram que o índice mitótico (IM) das raízes de cebola submetidas ao tratamento com látex, nas condições testadas, não diferiram significativamente do controle negativo, e sugerem que o látex não é citotóxico. Também foi observada uma baixa incidência de aberrações cromossômicas nas células tratadas com látex de H. speciosa, o que sugere que o látex também não possui efeito genotóxico. O IM e a frequência de aberrações cromossômicas foram dependentes da concentração de látex. Outros estudos devem ser realizados para avaliar o efeito da dose na genotoxidade. Os resultados indicam que o látex de mangabeira, nas concentrações testadas, provavelmente não é danoso para saúde humana e pode ter potencial para ser usado na medicina.Palavras-chave: Cerrado, medicina popular, mutagênese.

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“…The most worrying effects of the indiscriminate use of medicinal plants are embryotoxic, teratogenic and abortifacient, once the constituents of plants can cross the placenta and reach the fetus. 19 The plants cited as potentially toxic Arnica montana L., Artemisia vulgaris L., Stryphnodendron polyphyllum Mart., Vernonia condensata Baker, Echinodorus macrophyllus (Kunth) Micheli, Phyllanthus amarus Schumach. & Thonn., Mentha piperita L., among others.…”

Section: Discussionmentioning

confidence: 99%

Conhecimento sobre plantas medicinais e fitoterápicos de agentes comunitários de saúde de Ijuí/RS Knowledge on medicinal plants and herbal medicines by community health agents of Ijuí/RS

Schiavo

Schwambach

Colet

2017

R. pesq. cuid. fundam. online

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Objective: To assess the knowledge of medicinal plants and herbal medicines by Community Health Agents (ACS) in a ESF municipality Ijuí/RS. Method: Cross-sectional study, quantitative and qualitative, with 13 ACS. Data collection occurred in April 2014, and the analysis of quantitative data was done using descriptive statistics. The qualitative data were presented through the Collective Subject Discourse. Results: The main understanding of ACS on herbal medicine is related to the use of medicinal plants. Everyone agrees on the availability of plants and herbal medicines in the NHS, and provide information as to the mode of preparation and storage plants. Also believe that the incorrect use of plants can cause health hazards. Conclusion: There is a lack of knowledge about herbal medicine for ACS. Herbal medicine can and should be considered as a field of interaction of knowledge and practice that values and considers cultural resources, practices and local knowledge, with the involvement of the professional health care team. Todo el mundo está de acuerdo sobre la disponibilidad de plantas y hierbas medicinales en el NHS, y proporcionar información en cuanto a la forma de las plantas de preparación y almacenamiento. También creen que el uso incorrecto de las plantas puede causar riesgos para la salud. Conclusión: Existe una brecha de conocimiento con respecto a la fitoterapia por ACS. La medicina herbaria puede y debe ser considerado como un campo de interacción de los conocimientos y la práctica que valora y considera los recursos culturales, las prácticas y el conocimiento local, con la participación del equipo profesional de la salud. Descriptores: Plantas medicinales; Trabajadores de la Salud de la Comunidad; Fitoterapia. Descriptors

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Efeito embriotóxico, teratogênico e abortivo de plantas medicinais

Cited by 52 publications

References 26 publications

Toxicity of Jatropha curcas L. latex in Allium cepa test

Toxicity of Jatropha curcas L. latex in Allium cepa test

Evaluation of cytotoxicity and genotoxicity of Hancornia speciosa latex in Allium cepa root model

Conhecimento sobre plantas medicinais e fitoterápicos de agentes comunitários de saúde de Ijuí/RS Knowledge on medicinal plants and herbal medicines by community health agents of Ijuí/RS

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