To better understand the possible role of projected land use and cover change (LUCC) in future regional climate projections, we explored the regional climate change response from land use/cover change under different climate scenarios. To do so, we propose a research framework based on different SSP-RCPs to simulate and explore the impacts of future land use/cover changes on the future climate of Zhengzhou City, China, using the Weather Research and Forecasting (WRF) model with land use/cover and meteorological data under different SSP-RCP scenarios based on CMIP6. Two scenarios, SSP2-4.5 and SSP5-8.5, were compared and analyzed by simulating changes in future climate factors of temperature at 2 m height above ground(T2) and precipitation. The results show that T2 is higher for all 4 months by the year 2060 compared to that in the year 2030. Furthermore, a comparison of the abovementioned years showed that the mean temperatures of January and July were higher than those of SSP2-4.5 under the SSP5-8.5 scenario in both years, but in 2030, the mean T2 of April and October were lower than those of SSP2-4.5 under the SSP5-8.5 scenario. In terms of precipitation, both scenarios have no significant precipitation in July in 2030 and 2060, but there is an unusual increase in January and October.