Effects of lactose on intestinal calcium absorption in normal and lactase-deficient subjects

Cochet, B; Jung, A; Griessen, M; Bartholdi, P.; Schaller, Paul Schmutz; Donath, A

doi:10.1016/0016-5085(83)90194-4

Cited by 138 publications

(34 citation statements)

References 25 publications

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“…They, as well as Pansu and Chapuy [8], assumed that non-hydrolyzed lactose in these patients, may have enhanced ileal calcium absorption, which, together with the metabolic acidosis, led to the hypercalcemia. On the other hand, Cochet et al [9], showed increased intestinal calcium absorption in normal-lactase subjects and decreased calcium intestinal absorption in lactase-deficient subjects, with the assumption that the osmotic effect of unabsorbed lactose accelerates the intestinal transit time, decreasing the time of contact between calcium ions and intestinal mucosa.…”

Section: Discussionmentioning

confidence: 97%

Nephrocalcinosis in glucose-galactose malabsorption, association with renal tubular acidosis

et al. 2005

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Section: Discussionmentioning

confidence: 97%

Nephrocalcinosis in glucose-galactose malabsorption, association with renal tubular acidosis

et al. 2005

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“…The current recommendations for calcium intake in the UK are 700 mg/day for men and women over 19 years and 1250 mg/day during breastfeeding 92 . Interestingly, despite lactose intolerance, calcium from milk and dairy products is still well absorbed 93, 94 …”

Section: Lactose Intake Restriction Re‐introduction and Nutritionalmentioning

confidence: 99%

Review article: lactose intolerance in clinical practice – myths and realities

Lomer

Parkes

Sanderson

2007

Aliment Pharmacol Ther

467

331

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Summary Background Approximately 70% of the world population has hypolactasia, which often remains undiagnosed and has the potential to cause some morbidity. However, not everyone has lactose intolerance, as several nutritional and genetic factors influence tolerance. Aims To review current clinical practice and identify published literature on the management of lactose intolerance. Methods PubMed was searched using the terms lactose, lactase and diet to find original research and reviews. Relevant articles and clinical experience provided the basis for this review. Results Lactose is found only in mammalian milk and is hydrolysed by lactase in the small intestine. The lactase gene has recently been identified. ‘Wild‐type’ is characterized by lactase nonpersistence, often leading to lactose intolerance. Two genetic polymorphisms responsible for persistence have been identified, with their distribution concentrated in north Europeans. Symptoms of lactose intolerance include abdominal pain, bloating, flatulence and diarrhoea. Diagnosis is most commonly by the lactose hydrogen breath test. However, most people with hypolactasia, if given appropriate advice, can tolerate some lactose‐containing foods without symptoms. Conclusion In clinical practice, some people with lactose intolerance can consume milk and dairy foods without developing symptoms, whereas others will need lactose restriction.

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“…The ability to maintain high lactase activity throughout life is inherited as a dominant single‐gene trait. The results of studies on the role of LM in the development of bone mass have been controversial; the effect of lactose on the absorption of calcium has been shown to be dependent on lactase enzyme activity leading to decreased calcium absorption in lactase‐deficient subjects, 10 but opposite data have also been reported 11,12 …”

mentioning

confidence: 99%

Genetic Variant of Lactase‐Persistent C/T_‐13910 Is Associated with Bone Fractures in Very Old Age

Enattah

Sulkava

Halonen

et al. 2004

J American Geriatrics Society

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Effects of lactose on intestinal calcium absorption in normal and lactase-deficient subjects

Cited by 138 publications

References 25 publications

Nephrocalcinosis in glucose-galactose malabsorption, association with renal tubular acidosis

Nephrocalcinosis in glucose-galactose malabsorption, association with renal tubular acidosis

Review article: lactose intolerance in clinical practice – myths and realities

Genetic Variant of Lactase‐Persistent C/T_‐13910 Is Associated with Bone Fractures in Very Old Age

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Effects of lactose on intestinal calcium absorption in normal and lactase-deficient subjects

Cited by 138 publications

References 25 publications

Nephrocalcinosis in glucose-galactose malabsorption, association with renal tubular acidosis

Nephrocalcinosis in glucose-galactose malabsorption, association with renal tubular acidosis

Review article: lactose intolerance in clinical practice – myths and realities

Genetic Variant of Lactase‐Persistent C/T‐13910 Is Associated with Bone Fractures in Very Old Age

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Product

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Genetic Variant of Lactase‐Persistent C/T_‐13910 Is Associated with Bone Fractures in Very Old Age