Effects of Lactogenic and Gonadotropic Hormones on Hypophysectomized Pregnant Rats

Luteotropic Properties of Luteinizing Hormone and Nature of Oxytocin Induced Luteal Inhibition in Cattle

“…ovine prolactin, or equine luteinizing hormone (LH) did not. The luteotropie effects of prolactin in the rat have been clearly demonstrated (5,11), but attempts to show that prolactin was luteotropic h~ guinea pigs (1, 31), rabbits (18,30), cattle (35,36), sheep (12,26), goats (10), swine (32), and monkeys (8) have been unsuccessful or unconvincing. Kilpatrick et al (18) presented evidence that LH is luteotropic in hypophysectomized rabbits.…”

Ovarian function following pituitary stalk-section or hypophysectomy in the pig

“…The quantity of pituitary homogenate, HCG or PMSG re quired for implantation was one tenth of the level of tH or FSH activity required for implantation. Cutuly (1942) Averill, Ray and Lyons (1950) found that subcutaneous injections of day 12 rat placenta maintained pregnancy in rats hypophysectomized on the 6th day after mating. Injections were given for 6 days and consisted of 5 placenta, 275 mg placental tissue or 1 placenta and 0.5 mg estrone per day.…”

Ovarian function following pituitary stalk-section or hypophysectomy in the pig

“…The quantity of pituitary homogenate, HCG or PMSG re quired for implantation was one tenth of the level of tH or FSH activity required for implantation. Cutuly (1942) reported the maintenance of pregnancy in hypophysec tomized rats with the injection of pituitary gonadotropin plus LtH. The corpora lutea and progesterone production were maintained by this hormone treatment.…”