Luteotropic Properties of Luteinizing Hormone and Nature of Oxytocin Induced Luteal Inhibition in Cattle

Donaldson, Lloyd E.; Hansel, William; Vleck, L.D. Van

doi:10.3168/jds.s0022-0302(65)88223-6

Cited by 60 publications

(16 citation statements)

References 30 publications

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“…4). (Donaldson & Takken, 1968 Donaldson, Hansel & Van Vleck, 1965;Donaldson & Takken, 1968) PLATE 1 (Facing p. 262) local (uterine, Ginther, 1967), control mechanisms. However, as yet, no normal physiological role in ovarian function has been ascribed to oxytocin.…”

Section: Introductionmentioning

confidence: 99%

Effect of Continued Daily Injections of Oxytocin on Oestrous Cycle Length and Reproductive Tract Morphology in the Cow

Donaldson¹

1969

Reproduction

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Oxytocin produced epithelial cysts in the fimbria of the infundibulum, in the ampulla of the oviduct and in the mucosa of the endometrium of the uterus. There was mild cystic endometrial hyperplasia of the uterus, and occasional cyst formation in the rete ovarii. The epoophoron was dilated and distinct in many ovaries. Large luteinized follicles, apparently cystic, were present at slaughter in four heifers.

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Section: Introductionmentioning

confidence: 99%

Effect of Continued Daily Injections of Oxytocin on Oestrous Cycle Length and Reproductive Tract Morphology in the Cow

Donaldson¹

1969

Reproduction

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“…Since the injection caused a temporary reduction of the prolactin levels by 80-90%, the authors concluded that prolactin has little or no luteotrophic activity. Donaldson et al (1965) and Smith et al (1957) concluded that prolactin has no luteotrophic properties in the cow on the results of experiments in which the endogenous concentration of prolactin was increased by the injection of prolactin preparations. It appeared that the increased level of prolactin did not affect the concentration of progesterone in the peripheral blood or the duration of the oestrous cycle.…”

Section: Resultsmentioning

confidence: 99%

“…Bartosik et al (1967) demonstrated an increased progesterone production during perfusion of bovine ovaries in vitro with prolactin. Administration of prolactin to heifers to overcome oxytocin-induced luteal inhibition (Donaldson et al, 1965 ) did not increase progesterone levels to normal values. Administration of a lactogen preparation during the luteal phase of heifers had no effect on the duration of the oestrous cycle compared to the previous cycle (Smith et al, 1957), Moreover, Hoffmann et al (1974) observed no change in the progesterone level after a marked reduction ofprolactin which was caused by the administration of bromocryptine in the luteal phase of heifers.…”

Section: Introductionmentioning

confidence: 86%

Effect of chronic treatment with bromocryptine on the corpus luteum function of the cow

Bevers

Dieleman

1987

Animal Reproduction Science

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Six heifers received an intramuscular injection of 15 mg bromocryptine twice daily from day 1 (the day of standing oestrus was defined as day 0) until 50 h after the start of luteal regression. The overall mean level of prolactin was 0.22 __ 0.01 #g/1 (SEM; n = 6) in the bromocryptine-treated group and 10.7 + 2.7 ttg/1 (SEM; n=6) in the control group. No significant differences in the overall mean level of progesterone and LH, the mean length of the early-luteal phase, the luteal phase and the period of luteal regression were measured between the two groups. The results provide strong evidence that prolactin has no luteotrophic properties in the cow during the oestrous cycle.

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“…Whether luteal oxytocin also has a role in modulating the release of hormones from other endocrine tissues during the oestrous cycle should be the subject of further investigation (Donaldson, Hansel & Van Vleck, 1965;Tan, Tweedale & Biggs, 1982;Froehlick, Ben-Jonathan & Neill, 1984).…”

Section: Discussionmentioning

confidence: 96%

Evidence for the pulsatile release of PGF-2 inducing the release of ovarian oxytocin during luteolysis in the ewe

Moore¹,

Choy²,

Elliot³

et al. 1986

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Frequent blood samples were removed from a utero-ovarian vein, a jugular vein and a femoral artery of 5 ewes during luteolysis. Analysis of these samples for oxytocin-associated neurophysin revealed a significant venous-arterial difference across the ovary and uterus but not across the head. This occurred during the pulsatile surges as well as when levels were basal and confirms the corpus luteum as a major source of the pulsatile surges of oxytocin-associated neurophysin and oxytocin that occur during CL regression and also of the elevated luteal phase concentrations of both hormones. The pulsatile surges of oxytocin-associated neurophysin measured in the utero-ovarian vein were accompanied by the release of an approximately equimolar amount of oxytocin. The concentration of PGF-2 alpha in the utero-ovarian vein samples began to increase before the levels of oxytocin and oxytocin-associated neurophysin started to increase. This suggests that uterine PGF-2 alpha initiates the release of ovarian oxytocin and oxytocin-associated neurophysin during luteolysis in the ewe.

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Luteotropic Properties of Luteinizing Hormone and Nature of Oxytocin Induced Luteal Inhibition in Cattle

Cited by 60 publications

References 30 publications

Effect of Continued Daily Injections of Oxytocin on Oestrous Cycle Length and Reproductive Tract Morphology in the Cow

Effect of Continued Daily Injections of Oxytocin on Oestrous Cycle Length and Reproductive Tract Morphology in the Cow

Effect of chronic treatment with bromocryptine on the corpus luteum function of the cow

Evidence for the pulsatile release of PGF-2 inducing the release of ovarian oxytocin during luteolysis in the ewe

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