Effects of Lactic Acid Bacteria (Lab) Supplement on The Growth Rate and Elimination of Enteropathogenic Bacteria in Calves

An, Hyang Mi; Lee, Do Kyung; Kyeong, Min; Lee, Si Won; Lee, Sang Jin; Kim, Buem Surk; Ha, Nam Joo

doi:10.5504/bbeq.2011.0085

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…In comparison to the CN group, the CD group exhibited a decreasing trend in the relative abundance of the Ligilactobacillus , and a significant reduction in the relative abundance of Alistipes , Enterorhabdus , Desulfovibrio , and Candidatus_Saccharimonas , and a significant increase in Bacteroides and [Ruminococcus]_torques_group . Ligilactobacillus is a lactic acid-producing probiotic in the gut, known for its various health benefits and alleviation of diarrhea ( An et al, 2011 ; Guerrero Sanchez et al, 2022 ). Alistipes , belonging to the Bacteroidetes phylum, may have protective effects against certain diseases such as liver fibrosis, colitis, and cardiovascular diseases, and it is a bacterium that produces short-chain fatty acids ( Parker et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…Ligilactobacillus , a probiotic producing lactic acid in the gut, is associated with various health benefits and diarrhea alleviation. Studies have shown that bacterial-produced lactic acid can significantly reduce TMA levels ( An et al, 2011 ; Park et al, 2020 ; Guerrero Sanchez et al, 2022 ), and CutC activity directly influences the production of TMA, a precursor to TMAO. It can be inferred that Ligilactobacillus may inhibit CutC activity and reduce TMA production by generating lactic acid.…”

Section: Discussionmentioning

confidence: 99%

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Dysfunction of cecal microbiota and CutC activity in mice mediating diarrhea with kidney-yang deficiency syndrome

Guo,

Fang,

Chen

et al. 2024

Front. Microbiol.

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ObjectivePrevious studies have indicated that diarrhea with kidney-yang deficiency syndrome leads to a disorder of small intestine contents and mucosal microbiota. However, the relationship of TMA-lyase (CutC) activity and TMAO with diarrhea with kidney-yang deficiency syndrome remains unexplored. Therefore, this study explores the relationship between cecal microbiota and choline TMA-lyase (CutC) activity, as well as the correlation between trimethylamine oxide (TMAO), inflammatory index, and CutC activity.MethodTwenty SPF-grade male KM mice were randomly divided into the normal group (CN) and the diarrhea model group (CD). Diarrhea mouse models were established by adenine combined with Folium sennae administration. CutC activity, TMAO, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) levels were detected, and the cecal content microbiota was sequenced.ResultAfter 14 days, diarrhea occurred in the CD group. Compared with the CN group, there was no significant change in the activity of CutC in the small intestine of the CD group, while the activity of CutC in the cecum was significantly increased, and the levels of TMAO, IL-6, and TNF-α showed a significant increase. The Chao1 index, Observed_species index, Shannon index, and Simpson index all exhibited a decreasing trend. The main changes at the bacterial genus level were Alistipes, Enterorhabdus, Desulfovibrio, Bacteroides, Candidatus_Saccharimonas, and [Ruminococcus]_torques_group. The results of LEfSe analysis, random forest analysis and ROC curve analysis revealed Paludicola, Blautia, Negativibacillus, Paraprevotella, Harryflintia, Candidatus_Soleaferrea, Anaerotruncus, Oscillibacter, Colidextribacter, [Ruminococcus]_torques_group, and Bacteroides as characteristic bacteria in the CD group. Correlation analysis showed a significant negative correlation between cecal CutC activity and Ligilactobacillus, and a significant positive correlation with Negativibacillus and Paludicola. The level of TMAO was significantly positively correlated with CutC activity and IL-6.ConclusionDiarrhea with kidney-yang deficiency syndrome significantly affects the physiological status, digestive enzyme activity, CutC activity, TMAO levels, and inflammatory response in mice. Additionally, there are changes in the composition and function of cecal microbiota, indicating an important impact of diarrhea with kidney-yang deficiency syndrome on the host intestinal microbiota balance. The occurrence of diarrhea with kidney-yang deficiency syndrome may be associated with dysbiosis of intestinal microbiota, increased CutC activity, elevated TMAO levels, and heightened inflammatory factor levels.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dysfunction of cecal microbiota and CutC activity in mice mediating diarrhea with kidney-yang deficiency syndrome

Guo,

Fang,

Chen

et al. 2024

Front. Microbiol.

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“…Kawakami et al reported that feeding milk replacers containing yeast and lactic acid bacteria to calves significantly increased their feed conversion rate, reduced the fecal score, and inhibited diarrhea [8]. An et al also found that lactic acid bacteria can regulate the balance of gastrointestinal flora in calves, reduce the number of pathogenic bacteria in their feces, improve their health, and reduce diarrhea [9]. The same study also reported that the probiotics colonized the intestinal tract of the animals and adhered to the surface of the intestinal mucosa, thus forming a microbial protective layer to prevent the invasion of pathogenic bacteria and reduce their living space.…”

Section: Introductionmentioning

confidence: 99%

Compound Probiotics Improve the Diarrhea Rate and Intestinal Microbiota of Newborn Calves

Liu

Wang

Simujide

et al. 2022

Animals

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We evaluated the effects of probiotic compounds on the composition of the gut microbiota. Forty newborn calves were random allocated to the lactic acid bacteria + yeast group (LS group), lactic acid bacteria group (L group), yeast group (S group), and control group (D group). Probiotics containing Lactococcus lactis subsp. lactis, Pediococcus pentosaceus, Lactobacillus plantarum, Saccharomyces cerevisiae, and Kluyveromyces marxianus were fed to calves in the three treatment groups for 15 days. The feeding process lasted 15 days. Fecal samples were collected from all calves at the end of the trial and analyzed using high-throughput 16S rRNA sequencing. Totals of 1,029,260 high-quality reads and 420,010,128 bp of sequences were obtained. Among the four groups, the alpha diversity of gut microbes was significantly higher in newborn cattle in the LS group than in those in the L, S, and D groups. Overall, the dominant phyla were Firmicutes, Actinobacteria, and Bacteroidetes, whereas Bifidobacterium was the most abundant phylum in the gut of cattle in the LS group. Newborn calves from the compound probiotic groups had closely clustered gut bacterial communities and had lower rates of diarrhea. Overall, compound probiotics regulated the intestinal microbiota community structure of newborn calves and improved intestinal health. New information relevant to the prevention of diarrhea is provided by our research in newborn calves.

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Properties of a New Probiotic Candidate and Lactobacterin-TK2 Against Diarrhea in Calves

Boranbayeva

Karahan

Tulemissova

et al. 2020

Probiotics & Antimicro. Prot.

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Effects of Lactic Acid Bacteria (Lab) Supplement on The Growth Rate and Elimination of Enteropathogenic Bacteria in Calves

Cited by 5 publications

References 23 publications

Dysfunction of cecal microbiota and CutC activity in mice mediating diarrhea with kidney-yang deficiency syndrome

Dysfunction of cecal microbiota and CutC activity in mice mediating diarrhea with kidney-yang deficiency syndrome

Compound Probiotics Improve the Diarrhea Rate and Intestinal Microbiota of Newborn Calves

Properties of a New Probiotic Candidate and Lactobacterin-TK2 Against Diarrhea in Calves

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