Properties of a New Probiotic Candidate and Lactobacterin-TK2 Against Diarrhea in Calves

Boranbayeva, Togzhan; Karahan, Aynur Gül; Tulemissova, Zhanara; Myktybayeva, Raya; Özkaya, Serkan

doi:10.1007/s12602-020-09649-4

Cited by 16 publications

(10 citation statements)

References 55 publications

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“…The expression of B mRNA and inflammatory factors further indicates that probiotic supply can effectively resist E. coli infection by enhancing the intestinal innate immune function of newborn calves. This is consistent with the results of previous studies (Dong et al, 2019;Boranbayeva et al, 2020;Kan et al, 2021). However, some studies believe that the physiological functions of different probiotic strains are different (Kang and Im, 2015).…”

Section: Discussionsupporting

confidence: 92%

Effects of Multispecies Probiotic on Intestinal Microbiota and Mucosal Barrier Function of Neonatal Calves Infected With E. coli K99

Nie

Luo³

et al. 2022

Front. Microbiol.

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Altered gut microbiota are implicated in inflammatory neonatal calf diarrhea caused by E. coli K99. Beneficial probiotics are used to modulate gut microbiota. However, factors that mediate host-microbe interactions remain unclear. We evaluated the effects of a combination of multispecies probiotics (MSP) on growth, intestinal epithelial development, intestinal immune function and microbiota of neonatal calves infected with E. coli K99. Twelve newborn calves were randomly assigned as follows: C (control, without MSP); D (E. coli O78:K99 + gentamycin); and P (E. coli O78:K99 + supplemental MSP). All groups were studied for 21 d. MSP supplementation significantly (i) changed fungal Chao1 and Shannon indices of the intestine compared with group D; (ii) reduced the relative abundance of Bacteroides and Actinobacteria, while increasing Bifidobacteria, Ascomycetes, and Saccharomyces, compared with groups C and D; (iii) improved duodenal and jejunal mucosal SIgA and total Short Chain Fatty Acids (SCFA) concentrations compared with group D; (iv) increased relative ZO-1 and occludin mRNA expression in jejunal mucosa compared with group D; and (v) enhanced intestinal energy metabolism and defense mechanisms of calves by reducing HSP90 expression in E. coli K99, thereby alleviating the inflammatory response and promoting recovery of mucosal function. Our research may provide direct theoretical support for future applications of MSP in ruminant production.

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Section: Discussionsupporting

confidence: 92%

Effects of Multispecies Probiotic on Intestinal Microbiota and Mucosal Barrier Function of Neonatal Calves Infected With E. coli K99

Nie

Luo³

et al. 2022

Front. Microbiol.

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“…To test if these strains may suppress pathogenic strains as suggested in Figure 5 , we conducted antimicrobial activity of these strains against E. coli and S . Typhimurium, which can cause calf diarrhea ( Boranbayeva et al, 2020 ). All Lactobacillus spp.…”

Section: Resultsmentioning

confidence: 99%

“…Antimicrobial activity of the Lactobacillus isolates was assessed against Escherichia coli KCJ2K2616, E. coli K88 KCJ4567, and Salmonella enterica Typhimurium KCJ187. For antimicrobial activity of the isolates, the agar well diffusion method was 2 http://gephi.org used with slight modification (Espeche et al, 2009;Boranbayeva et al, 2020). Briefly, antimicrobial activities of filter (0.22 μm) sterilized supernatants of 18 h cultures of Lactobacillus spp.…”

Section: Isolation Of Lactobacillus Spp Strains and Antimicrobial Activitiesmentioning

confidence: 99%

“…We also identified Lactobacillus johnsonii, Lactobacillus amylovorus, and Ligilactobacillus animalis (formerly known as Lactobacillus animalis) in the normal feces (Figure 6B). To test if these strains may suppress pathogenic strains as suggested in Figure 5, we conducted antimicrobial activity of these strains against E. coli and S. Typhimurium, which can cause calf diarrhea (Boranbayeva et al, 2020). All Lactobacillus spp.…”

Section: Identification Of Lactobacillus Spp Strains and Their Antimicrobial Activitiesmentioning

confidence: 99%

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The Gut Microbiota of Newborn Calves and Influence of Potential Probiotics on Reducing Diarrheic Disease by Inhibition of Pathogen Colonization

et al. 2021

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Calf diarrhea is one of the most concerning challenges facing both the dairy and beef cattle industry. Maintaining healthy gut microbiota is essential for preventing gastrointestinal disorders. Here, we observed significantly less bacterial richness in the abnormal feces with watery or hemorrhagic morphology compared to the normal solid feces. The normal solid feces showed high relative abundances of Osllospiraceae, Christensenellaceae, Barnesiella, and Lactobacillus, while the abnormal feces contained more bacterial taxa of Negativicutes, Tyzzerella, Parasutterella, Veillonella, Fusobacterium, and Campylobacter. Healthy calves had extensive bacterial-bacterial correlations, with negative correlation between Lactobacillus and potential diarrheagenic Escherichia coli-Shigella, but not in the abnormal feces. We isolated Lactobacillus species (L. reuteri, L. johnsonii, L. amylovorus, and L. animalis), with L. reuteri being the most abundant, from the healthy gut microbiota. Isolated Lactobacillus strains inhibited pathogenic strains including E. coli K88 and Salmonella Typhimurium. These findings indicate the importance of a diverse gut microbiota in newborn calf’s health and provide multiple potential probiotics that suppress pathogen colonization in the gastrointestinal tract to prevent calf diarrhea.

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“…The calf diarrhoea has a high incidence especially in the first 4 weeks of a calves' life, resulting in a high mortality and morbidity rate [160]. The long-term, broad-spectrum antibiotics have conventionally been applied as therapy for the disease [161].…”

Section: Probioticsmentioning

confidence: 99%

Healthy Cattle Microbiome and Dysbiosis in Diseased Phenotypes

Khalil¹,

Batool²,

Arif³

2021

Preprint

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: Cattle farming is an ancient practice, with roots in the early Neolithic era that has retained its status in the food industry today, with global beef market revenue amounting to $385.7B, as of 2018. Hence, cattle maintenance is naturally essential to cater to nutritional requirements of modern civilization. This extensive review aims to provide a holistic overview of cattle microbiome, analysing the native microbial composition within respiratory tract, gastrointestinal tract, reproductive tract, and skin. The dysbiosis associated with various diseases such as bovine respiratory disease, bovine digital dermatitis, mastitis, Johne's disease, uterine diseases (metritis and endometritis) and metabolic disorders (ruminal acidosis and ketosis) has been discussed. Moreover, various non-antibiotic microbial therapies including phage therapy, prebiotics and probiotics have been examined as potential means to reduce disease-associated dysbiosis. In general, this review highlights the importance of the microbiome in maintenance of health in cattle and its potential in alleviating bovine diseases, with an aim to enhance cattle health and production.

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Properties of a New Probiotic Candidate and Lactobacterin-TK2 Against Diarrhea in Calves

Cited by 16 publications

References 55 publications

Effects of Multispecies Probiotic on Intestinal Microbiota and Mucosal Barrier Function of Neonatal Calves Infected With E. coli K99

Effects of Multispecies Probiotic on Intestinal Microbiota and Mucosal Barrier Function of Neonatal Calves Infected With E. coli K99

The Gut Microbiota of Newborn Calves and Influence of Potential Probiotics on Reducing Diarrheic Disease by Inhibition of Pathogen Colonization

Healthy Cattle Microbiome and Dysbiosis in Diseased Phenotypes

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