Effects of L-Tryptophan (A Natural Sedative) on Human Sleep

Wyatt, Richard Jed; Engelman, Karl; Kupfer, David J.; Fram, David H.; Sjoerdsma, Albert; Snyder, Frederick

doi:10.1016/s0140-6736(70)92015-5

Cited by 135 publications

(43 citation statements)

References 3 publications

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“…For example, the availability of dietary tryptophan shortens sleep latency and increases NREM sleep, SWS and sleep time (6)(7)(8)(9)(10)(11). Glycine ingestion before bedtime improves subjective quality of sleep and shortens latency of sleep and SWS without affecting sleep architecture (12).…”

mentioning

confidence: 99%

Effects of Nutrient Composition of Dinner on Sleep Architecture and Energy Metabolism during Sleep

Yajima

Seya

Iwayama

et al. 2014

J Nutr Sci Vitaminol

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Summary Energy metabolism and substrate oxidation during sleep correlate with sleep stage, suggesting that energy metabolism affects sleep architecture or vice versa. The aim of the present study was to examine whether changes in energy metabolism during sleep, induced by a high-carbohydrate or high-fat meal for dinner, affect sleep architecture. Ten healthy males participated in this study, sleeping 3 nonconsecutive nights in a whole-room calorimeter. The first night was scheduled as an adaptation to the experimental environment. The other 2 nights were experimental calorimetry in a balanced cross-over design with intrasubject comparisons. In each session, subjects comsumed a high carbohydrate (HCD: PFC510 : 10 : 80) or high fat (HFD: PFC510 : 78 : 12) meal at 2000 h and slept with a polysomnographic recording in a metabolic chamber for indirect calorimetry (0000 h to 0800 h). Slow wave sleep was decreased during the first sleep cycle and not changed during the second or third sleep cycle under HCD conditions compared with those of HFD. Energy expenditure was not affected by dietary condition but substrate oxidation reflected differences in dietary composition of the dinner during the first and second sleep cycle. The present study suggested the possibility that substrate availability during sleep affects substrate oxidation during sleep, and affects sleep architecture during the first sleep cycle.

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confidence: 99%

Effects of Nutrient Composition of Dinner on Sleep Architecture and Energy Metabolism during Sleep

Yajima

Seya

Iwayama

et al. 2014

J Nutr Sci Vitaminol

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“…Schneider-Helmert [37] noted that in three studies of psychiatric patients with severe insomnia [16,17,38), the effective dose range was 4-7.5 g, but the sleep-enhancing effects seen in these patients may have been more related to antidepressant effects of 1-tryptophan rather than to primary hypnotic effects. Brown et al [23] found that 1-tryptophan 3 g reduced sleep latency on some but not all nights of administration in laboratory-screened Insomniacs.…”

Section: Ho R O Td U I~~ -----mentioning

confidence: 99%

Psychopharmacological techniques for optimizing human performance

Spinweber¹,

Johnson²

1983

PsycEXTRA Dataset

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“…L-tryptophan has been called a "natural hypnotic" [16,17]. Plasma tryptophan levels, which show a diurnal rhythm with peak levels in the late evening hours, may be a physiological regulator of sleep onset.…”

Section: L-tryptophanmentioning

confidence: 99%

“…In earlier sleep laboratory studies, 1-tryptophan was reported to significantly reduce sleep latency in doses ranging from 1-15 g [18][19][20][21][22][23][24], but not all investigators have found sleep-facilitating effects [16,[25][26][27][28]. Decreased time awake and/or increased total sleep time were found in some laboratory studies [16,[19][20][21].…”

Section: L-tryptophanmentioning

confidence: 99%