Effects of L-thyroxine treatment on heart functions in infants with congenital hypothyroidism

Arslan, Alev; Baş, Veysel Nijat; Uytun, Salih; Poyrazoğlu, Hatice Gamze

doi:10.1515/jpem-2016-0393

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…In addition, studies claimed that treatment with L-T4 did not cause a significant difference in offspring development (45,46). L-T4 decreased the number of patients with thyroid deficiency also having gestational hypertension, LBW or VLBW babies, premature births and miscarriage, which is consistent with previously published studies (46,47). Therefore, the L-T4 administration protocols can be applied in obstetrics departments in patients with similar thyroid disorders.…”

Section: Discussionsupporting

confidence: 92%

Effects of thyroid diseases on pregnancy outcomes

Zhou

Wang

et al. 2019

Exp Ther Med

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The current study aimed to analyze the effects of thyroid diseases on pregnancy outcomes and investigate the effects of levothyroxine (L-T4) tablets in the treatment of hypothyroidism. The current study determined the prevalence of thyroid diseases using two diagnostic criteria, the prevalence of thyroid diseases among pregnant women recruited in 2010 and 2014 were initially determined by the 2011 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and Postpartum (2011 ATA Guidelines). Subjects were categorized into six groups: Normal, hypothyroxinemia, hypothyroidism, subclinical hypothyroidism (SCH), hyperthyroidism and subclinical hyperthyroidism. L-T4 was administered in the thyroid-insufficient groups and the prevalence rates of these categories were obtained using the diagnostic criteria from the 2011 ATA Guidelines and the 2012 Chinese Guidelines for the Diagnosis and Treatment of Thyroid Disease During Pregnancy and Postpartum (2012 Chinese Guidelines). The results of the current study demonstrated that the screening of thyroid function was significantly increased in 2014 (thyroid dysfunction rate, 82.4% vs. 29.1%; P<0.001). Hypothyroxinemia, hypothyroidism, SCH, hyperthyroidism and subclinical hyperthyroidism increased the likelihood of certain adverse outcomes and complications. L-T4 decreased the odds of gestational hypertension, premature birth and low birth weight or very low birth weight in the hypothyroidism group. A statistically significant difference was identified between thyroid disease incidences as determined by the 2011 ATA Guidelines 2012 Chinese Guidelines. In conclusion, abnormal thyroid levels increased the odds of adverse pregnancy outcomes, L-T4 administration improved pregnancy outcomes and the 2012 Chinese Guidelines may provide a better reference for Chinese pregnant women with subclinical hyperthyroidism.

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Section: Discussionsupporting

confidence: 92%

Effects of thyroid diseases on pregnancy outcomes

Zhou

Wang

et al. 2019

Exp Ther Med

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“…In addition to an increased risk of congenital heart disease (86-88), neonates with untreated CH may have increased aortic intimal-media thickness (IMT), serum cholesterol levels (197), and impaired cardiac function (198,199) reversed by early LT4 treatment (200).…”

Section: Discussionmentioning

confidence: 99%

Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update—An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology

Trotsenburg

Stoupa

Léger

et al. 2021

Thyroid

237

254

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Background: An ENDO-European Reference Network (ERN) initiative was launched that was endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology with 22 participants from the ENDO-ERN and the two societies. The aim was to update the practice guidelines for the diagnosis and management of congenital hypothyroidism (CH). A systematic literature search was conducted to identify key articles on neonatal screening, diagnosis, and management of primary and central CH. The evidence-based guidelines were graded with the Grading of Recommendations, Assessment, Development and Evaluation system, describing both the strength of recommendations and the quality of evidence. In the absence of sufficient evidence, conclusions were based on expert opinion. Summary: The recommendations include the various neonatal screening approaches for CH as well as the etiology (also genetics), diagnostics, treatment, and prognosis of both primary and central CH. When CH is diagnosed, the expert panel recommends the immediate start of correctly dosed levothyroxine treatment and frequent follow-up including laboratory testing to keep thyroid hormone levels in their target ranges, timely assessment of the need to continue treatment, attention for neurodevelopment and neurosensory functions, and, if necessary, consulting other health professionals, and education of the child and family about CH. Harmonization of diagnostics, treatment, and follow-up will optimize patient outcomes. Lastly, all individuals with CH are entitled to a well-planned transition of care from pediatrics to adult medicine. Conclusions: This consensus guidelines update should be used to further optimize detection, diagnosis, treatment, and follow-up of children with all forms of CH in the light of the most recent evidence. It should be helpful in convincing health authorities of the benefits of neonatal screening for CH. Further epidemiological and experimental studies are needed to understand the increased incidence of this condition.

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“…In the general population, L-T4 replacement has shown potential to lower cardiovascular disease incidence in patients with elevated TSH levels. 24 , 25 Badran et al. 26 have reported safe and effective short-term use of L-T4 in idiopathic dilated cardiomyopathy patients, suggesting that synthetic thyroid hormones might have a role in HF treatment when standard drugs fall short.…”

Section: Discussionmentioning

confidence: 99%

Effects of levothyroxine in subclinical hypothyroidism and heart failure with reduced ejection fraction: An open-label randomized trial

Wang,

Zhang,

Gao

et al. 2024

Cell Reports Medicine

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Effects of L-thyroxine treatment on heart functions in infants with congenital hypothyroidism

Abstract: Neonates with CH may exhibit systolic and diastolic heart dysfunction, which can be reversed by early L-T4 substitution treatment. The Tei index index should be measured in addition to conventional echocardiography.

Cited by 3 publications

References 11 publications

Effects of thyroid diseases on pregnancy outcomes

Effects of thyroid diseases on pregnancy outcomes

Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update—An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology

Effects of levothyroxine in subclinical hypothyroidism and heart failure with reduced ejection fraction: An open-label randomized trial

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