Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet

Спасов, А. А.; Iezhitsa, Igor Nikolayevich; Kravchenko, M. S.; Писарев, В. Б.; Снигур, Г Л

doi:10.1007/s10517-006-0391-x

Cited by 4 publications

(3 citation statements)

References 11 publications

(12 reference statements)

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“…Spiering et al [47] showed that carnitine attenuates metabolic stress that occurs after exercise. Numerous studies suggest beneficial effects of increased carnitine intake in reducing physical fatigue and recovery from exercise stress [48,49]. Conversely, some studies have shown no significant positive effects in exercise performance with carnitine [50,51].…”

Section: Discussionmentioning

confidence: 99%

Effect of L-carnitine Supplementation on Nutritional Status and Physical Performance Under Calorie Restriction

Jain

Singh

2014

Ind J Clin Biochem

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L-carnitine is popular as a potential ergogenic aid because of its role in the conversion of fat into energy. The present study was undertaken to investigate the effect of short term supplementation of L-carnitine on metabolic markers and physical efficiency tests under short term calorie restriction. Male albino rats were divided into four groups (n = 12 in each)-control, calorie restricted (CR for 5 days, 25 % of basal food intake), L-carnitine supplemented (CAR, given orally for 5 days at a dose of 100 mg/kg), CR with L-carnitine supplementation (CR ? CAR). Food intake and body weight of the rats were measured along with biochemical variables like blood glucose, tissue glycogen, plasma and muscle protein and enzymatic activities of CPT-1 (carnitine palmitoyl transferase-1) and AMP kinase. Results demonstrated that Lcarnitine caused marked increase in muscle glycogen, plasma protein, CPT-1 activity and swim time of rats (P \ 0.05) on short term supplementation. In addition to the substantive effects caused by CR alone, L-carnitine under CR significantly affected muscle glycogen, plasma protein, CPT-1 activity and AMP kinase (P \ 0.05). Short term CR along with L-carnitine also resulted in increased swim time of rats than control, CR and L-carnitine treated rats (P \ 0.05). The present study was an attempt towards developing an approach for better adherence to dietary restriction regimen, with the use of L-carnitine.

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Section: Discussionmentioning

confidence: 99%

Effect of L-carnitine Supplementation on Nutritional Status and Physical Performance Under Calorie Restriction

Jain

Singh

2014

Ind J Clin Biochem

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“…Спасова и соавт. [26][27][28] показали, что у здоровых крыс на фоне дефицита левокарнитина возможно развитие жировой дистрофии печени и атрофия скелетных мышц, а также снижение функциональных резервов миокарда и физической работоспособности [26][27][28].…”

Section: левокарнитин в лечении полиморбидных пациентовunclassified

Levocarnitine for the Treatment of Polymorbid Patients

Переверзев

Shevchenko

Filippova

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Effective and safe treatment of patients with polymorbidity is an urgent task of modern healthcare. Of particular difficulty is the treatment of patients with cardiovascular comorbidity, which requires an integrated approach to the treatment and development of a special, so-called patient-oriented approach. Modern scientific evidence proposes the use of levocarnitine, as part of complex therapy to increase its effectiveness. So, it was shown that levocarnitine can have a beneficial effect on blood pressure in patients with hypertension, especially those who are overweight and obese. Levocarnitine is also effective in the treatment of heart failure, which has been studied in several clinical studies, which demonstrated its ability to increase the ejection fraction of the left ventricle, stroke volume of blood and other indicators. Optimization of the bioavailability of nitrogen oxide (NO) and a decrease in systemic oxidative stress while taking levocarnitine plays an important positive role in complex therapy in patients with coronary artery disease: exertional angina and post-infarction cardiosclerosis, reducing the number of anginal attacks. Since levocarnitine has powerful antioxidant effects, it also has the neuroprotective effect found in in vitro studies in animal experiments. In case of impaired renal function, due to accelerated elimination and impaired reabsorption, a deficiency of levocarnitine in the body tissues develops, and therefore the US Food and Drug Administration (US FDA) decided on the possibility of using levocarnitine in patients on hemodialysis. Thus, taking into account the positive effects of levocarnitine in a number of frequently combined diseases, it can be considered as the drug of choice in the treatment of patients with polymorbidity.

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“…There are several other types of carnitine, in which D-carnitine is one of carnitine types. This inactive form may cause a carnitine deficiency in ones body by inhibiting the absorption of other and more useful forms (1). Secondly, acetyl-Lcarnitine is possibly the most effective form for the brain and previous study suggested that it may benefit people with neurodegenerative diseases (2).…”

Section: Introductionmentioning

confidence: 99%

Randomised Clinical Trial of Combined L-Carnitine Supplement and Exercise on Biochemical Markers and Exercise Performance: A Systematic Review

Samsudin¹,

Ahmad²,

Ooi³

et al. 2023

MJMHS

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Aim and design: L-carnitine supplementation combined with exercise may enhance metabolic responses and improve exercise performance. Thus, this systematic review article aims to identify the effects of the L-carnitine supplement on biochemical markers, and exercise performance when combined with exercise. Data Sources: The articles are screened and reviewed based on titles, abstracts and keywords. Only peer-reviewed studies written in the English language, dated January 2000 to March 2021, were considered in this review. Review Methods: The PRISMA method is used for this study. PubMed, EBSCOHost, SpringerLINK, and Scopus databases were used to systematically search. Results: From a search 731 articles, 12 articles were identified related to effect of L-carnitine intake with exercises on biochemical markers and exercise performance. Studies showed that L-carnitine supplementation can be consumed daily during aerobic or anaerobic exercises by different population including patients. Its combination could improve serum lipid profiles, antioxidant properties, markers of metabolic, oxidative stress, and inflammatory, and exercise performance. Conclusion and Impact: This review provides information regarding the beneficial effects of L-carnitine supplement with recommended dosages and exercise prescriptions on overall body health in human.

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Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet

Cited by 4 publications

References 11 publications

Effect of L-carnitine Supplementation on Nutritional Status and Physical Performance Under Calorie Restriction

Effect of L-carnitine Supplementation on Nutritional Status and Physical Performance Under Calorie Restriction

Levocarnitine for the Treatment of Polymorbid Patients

Randomised Clinical Trial of Combined L-Carnitine Supplement and Exercise on Biochemical Markers and Exercise Performance: A Systematic Review

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