Effects of L-Carnitine on Production Performance, Blood Parameters, Lipid Metabolism and Antioxidative Properties of Broiler Chicks.

Abstract

ABSTRACT:This study aimed to investigate the effects of L-carnitine (LC) on productive performance, carcass composition, blood parameters as well as the lipid metabolism, immune response and antioxidative properties of broiler chicks from day 7 to 35 of age. A total of 280 unsexed Cobb chicks were assigned equally into four treatment groups. The first group fed a basal diet (control), while the other three groups were fed basal diet supplemented with 50, 100 and 150 mg of LC/ kg diet. Supplementation of LC to diets significantly increased BW, BWG, decreased FI and improved FCR, economical efficiency and production index. Where, Chicks fed basal diet supplemented with 50 mg of LC had significantly higher final BW and BWG, lower FI and better values of FCR, economical efficiency and production index followed by those fed basal diet supplemented with 100 and 150 mg LC compared to the control group. Treated groups significantly decreased serum urea, creatinine, alanine amino transferase (ALT), aspartate amino transferase (AST), total lipids, triglycerides, cholesterol and low-density lipoprotein (LDL) while increased glucose, high-density lipoprotein (HDL), total protein, total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione (GSH), triiodothyronine (T3), thyroxine (T4), hemoglobin, packed cell volume (PCV), red blood cell (RBC's), white blood cell (WBC's), lymphocyte, globulin, α -globulin, globulin -β and globulin-γ, immunoglobulins (IgG, IgM and IgA), bactriocide activity (BA), lymphocyte transformation test (LTT), phagocytic activity (PA) and index (PI) compared to control group. Feeding diet with LC significantly increased carcass dressing and total edible parts and decreased abdominal fat compared to the control. In conclusion: L-carnitine supplementation to broiler diets improved productive performance, economical efficiency, immune response and antioxidative properties of broiler.

Influence of dietary L‐carnitine and lysine–methionine levels on reproductive performance and blood metabolic constituents of breeder ducks

“…In the present study, increasing Lys‐Met above NRC recommendations with or without L‐carnitine improved feed efficiency, but L‐carnitine or Lys‐Met alone had no effects on feed utilization and egg production. These results partially agreed with those obtained by El‐kelawy, 2017 ; Rizk et al., 2019 ; Sigolo et al., 2019 . In a previous study, Leibetseder ( 1995 ) also found no effect of dietary L‐carnitine (500 mg/kg) on laying performance of broiler breeders.…”

Effects of calf thymus extract and L-carnitine on immunity and growth performance of broiler chickens

“…This agree with the previous findings reporting that L-carnitine significantly increased globulin, phagocytic activity, phagocytic index and significantly decreased A/G ratio. 35 Our findings revealed that L-carnitine significantly increased interleukin 2 producing from T-helper cells. This agree with the other studies demonstrating that L-carnitine in mice exhibiting a modification in production of a number of cytokines (interferon, tumor necrosis factor, IL2, IL-4, IL-6, vascular endothelial growth factor and insulin-like growth factor in serum.…”

“…36 This results may be attributed to a positive effect of L-carnitine on humoral immunity by increasing lymphocyte cells%, phagocytic activity, phagocytic index, globulins and interleukin 2. 14,37,35 Our results showed improvement in RBCs count, Hb concentration and PCV after oral administration of calf thymus extract in broilers. This agree with the previous findings reporting that calf thymus preparation (TFX-Polfa) was significantly increased in the hemoglobin concentration and erythrocyte counts.…”

Effect of L-Carnitine and/or Calf Thymus Gland Extract Supplementation on Immunity, Antioxidant, Duodenal Histomorphometric, Growth, and Economic Performance of Japanese Quail (Coturnix coturnix japonica)

“…Additionally, birds supplemented with dietary LC showed a decrease in feed intake, and this feed reduction may be due to the ability of birds to compensate their feed reduction according to their energy requirements with similar metabolizable energy diets [30]. FCR improvement was previously linked to a reduction in feed intake and an increase in body weight gain in broiler chicks [37]. Our outcomes differ from Soliman et al [10] and Xu et al [38] findings who found that the administration of LC and/or TE in feeds and/or water did not affect broiler FCR.…”