Effects of kefir fractions on innate immunity

Vinderola, Gabriel; Perdigón, Gabriela; Duarte, Júlio César; Thangavel, D.; Farnworth, E. R.; Matar, Chantal

doi:10.1016/j.imbio.2005.08.005

Cited by 97 publications

(72 citation statements)

References 41 publications

(39 reference statements)

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“…In this sense, kefir supernatant may be able to promote cell-mediated immune responses against tumors and also against intracellular pathogenic infections. Vinderola et al (2006b) orally administered kefir supernatant to mice and found that production of pro-inflammatory cytokines, including TNF-a and IL-6, was induced on peritoneal macrophages, but not IL-1a. Although both IL-1a and IL-1b produced by macrophages, monocytes and dendritic cells form an important part of the inflammatory response of the body against infection, the different original kefir grains possessing diverse microorganisms (Farnworth and Mainville, 2003;Witthuhn et al, 2004) were able to differentially modulate the immune response.…”

Section: Discussionmentioning

confidence: 99%

Effects of kefir supernatant and lactic acid bacteria isolated from kefir grain on cytokine production by macrophage

Hong

Chen

et al. 2009

International Dairy Journal

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Section: Discussionmentioning

confidence: 99%

Effects of kefir supernatant and lactic acid bacteria isolated from kefir grain on cytokine production by macrophage

Hong

Chen

et al. 2009

International Dairy Journal

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“…5 There is also a growing number of publications reporting on the use of purified exopolysaccharides as immunostimulatory substances in the experimental therapy. 6,7 During the investigations concerning the immunological activity of various polysaccharides from probiotic bacterial strains, the information about the molecular structure of the polysaccharide is essential. While structures of a number of EPSs of LAB are described, they come mainly from the strains of industrial significance.…”

Section: Introductionmentioning

confidence: 99%

Structural and immunochemical studies of neutral exopolysaccharide produced by Lactobacillus johnsonii 142

Górska

Jachymek

Rybka

et al. 2010

Carbohydrate Research

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“…Live weight gain in kefir, koumiss, milk and yoghurt group being more compared to the control group suggests that it arise from kefir, koumiss, milk and yoghurt containing different beneficial organisms [25] . Beyond the inherent high nutritional value as a source of protein and calcium, kefir is believed to be beneficial to health in the countries where kefir is an essential part of the diet culture for a long time [26,27] . Effects of kefir on antioxidant and growth factors have been shown in several studies [22,[28][29][30][31][32][33] found that the protective effect of kefir is more than vitamin E in oxidative damage induced by CCl 4 in mice, by reducing lipid peroxidation and increasing reduced glutathione and glutathione peroxidase levels.…”

Section: Discussionmentioning

confidence: 99%

Kefir, Kımız, Süt ve Yoğurt Uygulamasının Fare Dalağında Plazma Hücresi ve Mast Hücrelerinin Dağılımı Üzerine Etkileri

Yildiz¹,

Yi̇ği̇t²,

Aydın³

et al. 2015

Kafkas Univ Vet Fak Derg

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The present study was conducted to investigate the effect of kefir, koumiss, milk and yoghurt administration on plasma cells, which synthesize specific antibodies against antigens, and mast cells, which have a role in the regulation of humoral and cellular events, in the mice spleen tissues. Mice (n=30) were divided into 5 groups. As a result of statistical evaluation, live weights of mice in kefir, koumiss, milk and yoghurt groups were found to be increased compared to the control group. When numbers of plasma cells in spleens of mice treated with kefir, koumiss, milk and yoghurt were checked with stereological methods, significant difference was found to be increased in number of plasma cells of kefir-treated mice compared to other groups at the end of 15 days. At the end of day 15, a significant difference was found to be increased in the number of mast cells in the spleen of milk-treated mice compared to control group. As the number of plasma cells in the spleen is at higher level with kefir, than with koumiss, milk and yoghurt; also there being a significant difference between the numbers of mast cells in the spleens of mice treated with milk compared to control group, this is remarkable for healthy eating/functional food. Kefir, Koumiss, Milk, Yoghurt, Plasma cell, Mast cell Keywords: Kefir, Kımız, Süt ve Yoğurt Uygulamasının Fare Dalağında Plazma Hücresi ve Mast Hücrelerinin Dağılımı Üzerine Etkileri ÖzetBu çalışma, kefir, kımız, süt ve yoğurt uygulamasının fare dalak dokusunda, karşılaştıkları antijene spesifik antikor sentezleyen plazma hücreleri ile humoral ve hücresel olayların düzenlemesinde rolü olan mast hücrelerinin sayısal dağılımını belirlenmeyi amaçlanmıştır. Fareler (n=30) her grupta 6 adet olacak şekilde 5 gruba ayrıldı. İstatiksel değerlendirmeler sonucunda kefir, kımız, süt ve yoğurt grubunda bulunan farelerin canlı ağırlıklarının kontrol grubuna göre arttığı tespit edildi. Kefir, kımız, süt ve yoğurt uygulanan farelerin sterelojik yöntemle dalaktaki plazma hücreleri sayısına bakıldığında 15. günün sonunda kefir uygulanan farelerin dalağında plazma hücrelerinin sayısında diğer gruplara göre anlamlı bir artışın olduğu tespit edildi. 15. günün sonunda süt uygulanan farelerin dalağında mast hücrelerinin sayısında kontrol grubuna göre anlamlı bir artışın olduğu belirlendi. Yararlı mikroorganizmalardan oluşan kefirin, dalaktaki plazma hücre sayısına bakıldığında kımız, süt ve yoğurttan daha yüksek düzeyde bulunması; ayrıca süt uygulanan farelerin dalağında mast hücrelerinin sayısında kontrol grubuna göre anlamlı bir farkın olması sağlıklı beslenme/fonksiyonel gıda kapsamında dikkat çekicidir.

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Effects of kefir fractions on innate immunity

Cited by 97 publications

References 41 publications

Effects of kefir supernatant and lactic acid bacteria isolated from kefir grain on cytokine production by macrophage

Effects of kefir supernatant and lactic acid bacteria isolated from kefir grain on cytokine production by macrophage

Structural and immunochemical studies of neutral exopolysaccharide produced by Lactobacillus johnsonii 142

Kefir, Kımız, Süt ve Yoğurt Uygulamasının Fare Dalağında Plazma Hücresi ve Mast Hücrelerinin Dağılımı Üzerine Etkileri

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