Effects of kava-kava extract on the sleep–wake cycle in sleep-disturbed rats

Shinomiya, Kazuaki; Inoue, Takuya; Utsu, Yoshiaki; Tokunaga, Shin; Masuoka, Takayoshi; Ohmori, Asae; Kamei, Chiaki

doi:10.1007/s00213-005-2196-4

Cited by 42 publications

(40 citation statements)

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“…It is well known that delta activity is an indicator of depth within non-REM sleep (18 -20). A decrease in delta activity has been also reported for other benzodiazepines, such as triazolam, flunitrazepam and midazolam, during non-REM sleep (17,21,22). From these findings, it became clear that benzodiazepines produced an increase in the quantity of sleep, but the sleep quality deteriorated.…”

Section: Discussionmentioning

confidence: 57%

“…On the other hand, it was found that nitrazepam caused a significant decrease in delta activity during non-REM sleep. Delta activity is thought to reflect sleep quality (17). It is well known that delta activity is an indicator of depth within non-REM sleep (18 -20).…”

Section: Discussionmentioning

confidence: 99%

“…From these findings, it became clear that benzodiazepines produced an increase in the quantity of sleep, but the sleep quality deteriorated. Although the mechanism of the sleep quality deterioration induced by benzodiazepine is not clear, it is almost certain that the decrease in delta activity by benzodiazepines may not be mediated by benzodiazepine receptors (17,23).…”

Section: Discussionmentioning

confidence: 99%

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Effects of Some H1-Antagonists on the Sleep-Wake Cycle in Sleep-Disturbed Rats

et al. 2007

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Abstract. The present study was undertaken to investigate the effects of some H 1 -antagonists on the sleep-wake cycle in sleep-disturbed rats in comparison with those of nitrazepam. Electrodes were chronically implanted into the frontal cortex and the dorsal neck muscle of rats for the electroencephalogram (EEG) and electromyogram (EMG), respectively. EEG and EMG were recorded with an electroencephalograph. SleepSign ver. 2.0 was used for EEG and EMG analysis. The total times of waking, non-rapid eye movement (non-REM), and rapid eye movement (REM) sleep were measured from 10:00 to 16:00. Nitrazepam showed a significant decrease in sleep latency, total waking time, and delta activity and an increase in the total non-REM sleep time. A significant decrease in the sleep latency was observed with diphenhydramine, chlorpheniramine, and cyproheptadine. Cyproheptadine also caused a significant decrease in the total waking time and increases in total non-REM sleep time, REM sleep time, slow wave sleep, and delta activity, although no remarkable effects were observed with diphenhydramine and chlorpheniramine. In conclusion, cyproheptadine can be useful as a hypnotic, having not only sleep inducing-effects, but also sleep quantity-and quality-increasing effects.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of Some H1-Antagonists on the Sleep-Wake Cycle in Sleep-Disturbed Rats

et al. 2007

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“…Flunitrazepam had no significant effect on any of the parameters examined, even at the highest dose tested (3 mg/kg). Contrariwise, Shinomiya et al 18) reported that flunitrazepam at 3 mg/ kg caused a decrease in sleep latency, a decrease in wake time, and an increase in non-REM sleep time in rats whose sleep was disturbed by both water-and altitude-induced stress. Flunitrazepam is a benzodiazepine hypnotic that binds to the GABA A receptor and enhances the effect of GABA.…”

Section: Discussionmentioning

confidence: 99%

Effects of the 5-HT<sub>1A</sub> Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats

Tsutsui

Shinomiya

Sendo

et al. 2015

Biological & Pharmaceutical Bulletin

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“…A escolha da banda delta justifica-se pelo fato desta estar relacionada a mecanismos de sono/vigília 1 5 . Estudos com ansiolíticos e ervas usadas para distúrbios do sono, com o Kava Kava, apontam para uma tendência de aumento da banda delta em diversas áreas corticais 11,16 .…”

Section: Métodounclassified

Efeitos neuromoduladores do bromazepam quando indivíduos são expostos a uma tarefa de aprendizagem motora: eletrencefalografia quantitativa (EEGq)

Salles

Bastos

Cunha

et al. 2006

Arq. Neuro-Psiquiatr.

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RESUMO -Os efeitos sedativos do bromazepam no desempenho cognitivo têm sido amplamente investigados. Várias abordagens têm sido implementadas no intuito de avaliar a influência do bromazepam em sujeitos submetidos à tarefa motora. Neste contexto, o presente estudo objetiva avaliar as alterações eletro f i s i o l ó g i c a s em sujeitos expostos à tarefa de datilografia e tratados com bromazepam (6 mg). Os dados do EEGq foram gravados simultaneamente à tarefa. Em part i c u l a r, a potência relativa na banda delta (0,5-3,5 Hz) foi analizada. O tempo de execução e erros durante a tarefa foram considerados variáveis comportamentais. O grupo experimental (bromazepam 6 mg) demonstrou melhor desempenho e valores de potência relativa mais elevados que o grupo controle (placebo). Estes resultados sugerem que menor nível de ansiedade favorece o desempenho motor.PALAVRAS-CHAVE: bromazepam, aprendizagem motora, EEGq, banda delta.Neuromodulatory effects of bromazepam when individuals were exposed to a motor learning task: quantitative electroencephalography (qEEG)ABSTRACT -The sedative effects of bromazepam on cognitive and perf o rmance have been widely investigated. A number of different approaches have assessed the influence of bromazepam when individuals are engaged to a motor task. In this context, the present study aimed to investigate electrophysiological changes when individuals were exposed to a typewriting task after taking 6 mg of bromazepam. qEEG data were simultaneously re c o rded during the task. In part i c u l a r, relative power in delta band (0.5-3.5 Hz) was analyzed. Time of execution and errors during the task were re g i s t e red as behavioral variables. The experimental group, bromazepam 6mg, showed a better motor perf o rmance and higher relative power than control individuals (placebo). These results suggest that the use of bromazepam reduces anxiety levels as expected and thus, produces an increment in motor performance.KEY WORDS: bromazepam, motor learning, qEEG, delta band.Experimentos sobre processos de aquisição de habilidades motoras contribuem para o entendimento de como o SNC integra e incorpora diferentes fontes de informação e possíveis variações em enferm i d a d e s ou na utilização de medicamentos. O bro m a z e p a m atua como um ansiolítico e, em dose mais elevada, pode apresentar efeito hipnótico e miorre l a x a n t e 1 -4 . Ele atua como neuro m o d u l a d o r, facilitando a interação do transmissor GABA com seu re c e p t o r 1 . Este efeito ocorre em vários níveis do sistema nerv o s o

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Effects of kava-kava extract on the sleep–wake cycle in sleep-disturbed rats

Abstract: Kava-kava extract is an herbal medicine having not only hypnotic effects, but also sleep quality-enhancement effects.

Cited by 42 publications

References 21 publications

Effects of Some H1-Antagonists on the Sleep-Wake Cycle in Sleep-Disturbed Rats

Effects of Some H1-Antagonists on the Sleep-Wake Cycle in Sleep-Disturbed Rats

Effects of the 5-HT<sub>1A</sub> Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats

Efeitos neuromoduladores do bromazepam quando indivíduos são expostos a uma tarefa de aprendizagem motora: eletrencefalografia quantitativa (EEGq)

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