Effects of Kamishoyosan, a Traditional Japanese Kampo Medicine, on Pain Conditions in Patients with Intractable Persistent Dentoalveolar Pain Disorder

Abstract

There are patients who suffer from persistent dentoalveolar pain disorder (PDAP) which is a pain of the teeth, either dentoalveolar pain or nonodontogenic toothache, and its cause has not yet been identified. An effective intervention for PDAP has not yet been established. Interventions for patients with PDAP are generally pharmacological treatments such as antidepressants, anticonvulsants, and pregabalin. However, these medicines are not always effective for patients. The pain disorder in the orofacial region including temporomandibular disorder (TMD) and PDAP was effectively treated with our original exercise therapy. However, we did observe some intractable cases of PDAP even when our original exercise therapy was used. This paper presents our findings in which Kamishoyosan improved the pain intensity in 14 out of 15 PDAP patients refractory to our original exercise therapy.

Paeonol, an Ingredient of Kamishoyosan, Reduces Intracellular Lipid Accumulation by Inhibiting Glucocorticoid Receptor Activity in 3T3-L1 Cells

“…The 129 kinds of Kampo medicines can be divided into two groups: those with and without Bupleuri Radix (BR). KSS contains BR and is prescribed for climacteric disorder and orofacial pain [35,36]. In this study, we examined the effects of Hochuekkito (HET), Shoseiryuto (SST), and Goreisan (GRS), as the control of KSS.…”

Kampo for the Treatment of Pain in Japan: A Review

“…Kampo consists of a system of essentially three dichotomies and three substance concepts [3][4][5][6][7][8]. The three dichotomies are: Yin-You (yingyang), Kyo-Jitsu, and Netsu-Kan (translated into English as ''positive-negative'', ''hollow-full'', and ''hot-cold'', respectively).…”

“…PDAP is effectively treated by using a unique exercise therapy for the improvement of jaw movement in combination with psychological intervention to reduce parafunctional activities. Kamishoyosan is a Kampo formula used to effectively treat psychological symptoms such as anxiety, irritability, and depression [5]. A prospective study showed that Kamishoyosan improved the pain intensity in 14 out of 15 PDAP patients refractory to the original exercise therapy.…”