Effects of jaboticaba (Myrciaria jaboticaba) peel on blood glucose and cholesterol levels in healthy rats

Batista, Ana Beatriz Esteves; Leite-Legatti, Alice Vieira; Lima, May; Prado, Marcelo Alexandre; M., M. R.

doi:10.5897/ajb2014.14013

Cited by 7 publications

(5 citation statements)

References 28 publications

(30 reference statements)

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“…The liver plays a major role in body's metabolism system. Increased levels of endogenous hepatic enzymes are indicative of damage and/or tissue overload (Batista et al, 2014). Therefore, these data suggest that JAE is a suitable source of natural antioxidants, encouraging further research with it, especially given the toxicity of many of the herbal preparations described in the literature (Teschke, Wolff, Frenzel, & Schulze, 2014).…”

Section: In Vivo Experimentsmentioning

confidence: 88%

“…caba peel (daSilva et al, 2017), showing that aqueous extraction is able to remove polyphenols from the peel, mainly anthocyanin, resulting in a demonstrably strong antioxidant capacity. This extraction method could be easily applied to in vivo use since benefits of the jaboticaba peel have already been shown, such as positive effects on antioxidant defense, glycemic response, and lipid levelsBatista, Leite-Legatti, De Lima, Prado, & Maróstica Junior, 2014;Plaza et al, 2016). In this sense, this study confirmed the efficacy of aqueous extraction, using in vitro tests as a means of obtaining bioactive compounds from jaboticaba (P. jaboticaba) peel in order to evaluate the in vivo effects of the extract on anti-radical defenses and gut microbiota in healthy rats.…”

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confidence: 99%

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Aqueous extract of berry (Plinia jaboticaba)byproduct modulates gut microbiota and maintains the balance on antioxidant defense system in rats

et al. 2018

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Previous studies have assessed the properties of aqueous extracts, using byproducts such as jaboticaba peel. We have assessed potential antioxidant effects of jaboticaba extract (Plinia jaboticaba) (JAE = 50 g/L) in vitro and in vivo. Healthy Wistar rats received ad libitum JAE for either 15 or 49 days in vivo. Cyanidin‐3‐O‐glucoside, delphinidin‐3‐O‐glucoside, gallic acid, rutin, myricetin, and quercetin were identified as the main polyphenols in JAE. Lipid peroxidation values in the serum and colon were similar throughout the groups. In addition, JAE did not disturb the antioxidant systems. JAE also altered gut microbiota, increasing since Lactobacillus, Bifidobacterium and Enterobacteriaceae counts. Bacterial metabolites were higher in the colon content of rats fed with JAE than in the control group. Given these results, under healthy conditions, JAE dietary supplementation could perform in vivo modulation of gut microbiota, without disturbing the antioxidant system. Practical application Jaboticaba (Plinia jaboticaba) peel is a rich and often‐wasted source of bioactive compounds, such as polyphenols. Previous studies have shown that physiological benefits of this berry. The jaboticaba peel could contribute to antioxidant defense systems; it may also have an effect over gut microbiota related to polyphenols contents. Aqueous extraction may be a practical way of employing the bioactive compounds of jaboticaba peel; these compounds can be consumed daily and safely, and thus have attracted particular attention. This work showed positive impacts of jaboticaba peel treatments on microbiota and antioxidant defense systems, and could guide future clinical studies.

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Section: In Vivo Experimentsmentioning

confidence: 88%

mentioning

confidence: 99%

Aqueous extract of berry (Plinia jaboticaba)byproduct modulates gut microbiota and maintains the balance on antioxidant defense system in rats

et al. 2018

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“…However, the administration period of the jaboticaba extract was carried out on older animals than those observed in the present study and the experimental model did not present Pca (Baseggio et al, 2018). Also, different studies showed that the 1%, 2% and 4% of the freeze-dried jaboticaba peel, added to the diet for 10 weeks, was not able to reduce weight gain and or food intake in the high-fat fed rats (Lenquiste et al, 2012;Batista, Â. G. et al, 2014). Thus, our findings suggest that PJE has the potential to be used as a therapeutic agent for prevention and treatment of overweight under PCa conditions.…”

Section: Discussionmentioning

confidence: 62%

“…Research has demonstrated that the 4% freeze-dried jaboticaba peel, added to the diet, increased the GPx and SOD activities in the liver and also increased the antioxidant activity in the plasma, brain and kidney of the rats fed with a HFD (Lenquiste et al, 2012;Batista, Â. G. et al, 2014). Nowadays, Lamas and collaborators (2018) showed that patented jaboticaba peel extract (PJE) administration, decreased the hyperglycemia, insulin resistance and dyslipidemia besides preventing hepatic steatosis in HFD senile FVB mice.…”

Section: Introductionmentioning

confidence: 99%

Resposta do microambiente do adenocarcinoma de próstata em camundongos tramp ao tratamento com extrato da casca da jabuticaba ou berberina, associado ao efeito tumorigênico da dieta hiperlipídica

Nogueira Lima

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Agradeço a Deus por me capacitar e dar forças para vencer a depressão e caminhar em direção a concretização desse trabalho.A minha família, Paula, Marcelo, Alan e Henrique, por apoiarem e torcerem pelos meus objetivos de vida.Ao Marçal, por me ajudar a atravessar um dos momentos mais difíceis da minha vida, possibilitando minha chegada até aqui.Ao Henrique Fonseca, pela parceria de vida e por sempre demonstrar sua admiração por minhas conquistas profissionais.Aos meus amigos Lia, Melissa e João, por sempre se fazerem presentes com momentos de encorajamento e ajuda em meio aos revezes da minha vida.A Professora Doutora Valéria Helena Alves Cagnon Quitete, pela oportunidade de realização deste projeto em seu laboratório e por sempre se disponibilizar para idealização e orientação desta pesquisa.Ao Professor Doutor Mário Maróstica, pela co-orientação e disponibilização de seu laboratório e recursos.Aos meus colegas de laboratório, Isabela, Andressa, Celina, Larissa, Fabio, Giovana e Felipe, pela disponibilidade de ajuda no desempenho teórico e prático deste trabalho. Pelos momentos de amizade e confraternização.A Professora Doutora Lucia Elvira, por disponibilizar seu tempo e recursos em parceria científica.A Fernanda Veiga e Gabriela Chiarotto, pela dedicação de tempo de ensino nas fases experimentais.A Professora Doutora Elaine Minatel e seu laboratório de pesquisa, pela disponibilização de equipamentos e recursos.Aos técnicos do Departamento de Anatomia, Histologia e Engenharia de Alimentos pelo auxílio nas rotinas de laboratório.Ao CEMIB, por possibilitar o seguimento da linhagem experimental TRAMP desde sua chegada ao Brasil.Ao programa de Pós-graduação em Biologia Celular e Estrutural, por proporcionar a oportunidade de meu crescimento como cientista e docente.A FAPESP (processo 2018/04579/7) pelo suporte financeiro e incentivo a pesquisa.O presente trabalho foi realizado com apoio da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior -Brasil (CAPES) -Código de Financiamento 88882.329642/2019-01.Eu sou aquela mulher que fez a escalada da montanha da vida, removendo pedras e plantando flores. Cora Coralina RESUMOO câncer de próstata (PCa) é o tipo de câncer mais diagnosticado em homens. Nesse contexto, estudos apontam os efeitos antiproliferativos da jabuticaba e da berberina sobre diversas linhagens celulares de câncer, incluindo o de próstata. O presente estudo teve como objetivos a avaliação de parâmetros estruturais, antioxidativos, angiogênicos e epigenéticos do microambiente prostático de camundongos transgênicos para adenocarcinoma de próstata (TRAMP) frente ao tratamento com o extrato da casca da jabuticaba ou berberina, submetidos ou não à DH. Além disso, objetivou-se analisar os efeitos prótumorigênicos causados pela ingestão da DH sobre os parâmetros citados acima, nos grupos que não receberam tratamento. Camundongos TRAMP foram tratados ou não com extrato da casca da jabuticaba (ECJ) no período de 8 a 16 semanas de idade ou com a berberina no período de 12 a 16 semanas de idade, sendo ou nã...

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“…A casca de jabuticaba possui propriedade hipocolesterolêmica conhecida em animais saudáveis (BATISTA, Â. G. et al, 2014), pré-obesos(ARAÚJO et al, 2013, ou diabéticos . Trabalhos anteriores mostraram que a terapia de animais obesos com 4% de casca de jabuticaba não foi eficaz em diminuir o colesterol sanguíneo, porém estes animais demonstraram maior nível de HDL-colesterol , assim como no presente estudo.…”

Section: Dislipidemiaunclassified

Berry fruits

Batista¹

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Berries contain flavonoids involved in several mechanisms related to prevention of cognitive deficit, obesity, and insulin resistance. Accumulating evidence suggests that insulin resistance is the link associating obesity and Alzheimer's disease (AD). In this study, a high-fat diet was used to induce obesity and insulin resistance in mice and compared to a normal-fat standard diet. We have supplemented the both diets with 5% powder of freeze-dried Syzygium malaccense fruit (SMF) and investigated proofs of peripheral insulin resistance, hippocampal insulin sensitivity, learning/memory performance, tau protein stability, and brain frontal lobe oxidative stress. The high-fat diet supplemented with SMF (HS group) did not prevent weight gain but showed peripheral insulin sensitivity, improved insulin signaling in the hippocampus, which consequently reduced GSK3-β activity and lowered tau phosphorylation. The results from Morris water maze cognitive test were consistent with the finding, once the HS group showed better performance on learning/ memory tasksrelated to the hippocampus. Brain frontal lobe antioxidant enzyme activities were down-regulated when high-fat diet was consumed but the supplementation with SMF prevented lipid peroxidation and improved activities of catalase, superoxide dismutase, and glutathione peroxidase. SMF intake also elevated serum antioxidant defenses. The therapeutic intervention with SMF was effective in minimizing cognitive dysfunctions and in preventing risk factors associated to AD development in mice fed high-fat diet without changing energy metabolism.

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Effects of jaboticaba (Myrciaria jaboticaba) peel on blood glucose and cholesterol levels in healthy rats

Cited by 7 publications

References 28 publications

Aqueous extract of berry (Plinia jaboticaba)byproduct modulates gut microbiota and maintains the balance on antioxidant defense system in rats

Aqueous extract of berry (Plinia jaboticaba)byproduct modulates gut microbiota and maintains the balance on antioxidant defense system in rats

Resposta do microambiente do adenocarcinoma de próstata em camundongos tramp ao tratamento com extrato da casca da jabuticaba ou berberina, associado ao efeito tumorigênico da dieta hiperlipídica

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