Aqueous extract of berry (Plinia jaboticaba)byproduct modulates gut microbiota and maintains the balance on antioxidant defense system in rats

Abstract

Previous studies have assessed the properties of aqueous extracts, using byproducts such as jaboticaba peel. We have assessed potential antioxidant effects of jaboticaba extract (Plinia jaboticaba) (JAE = 50 g/L) in vitro and in vivo. Healthy Wistar rats received ad libitum JAE for either 15 or 49 days in vivo. Cyanidin‐3‐O‐glucoside, delphinidin‐3‐O‐glucoside, gallic acid, rutin, myricetin, and quercetin were identified as the main polyphenols in JAE. Lipid peroxidation values in the serum and colon were similar throughout the groups. In addition, JAE did not disturb the antioxidant systems. JAE also altered gut microbiota, increasing since Lactobacillus, Bifidobacterium and Enterobacteriaceae counts. Bacterial metabolites were higher in the colon content of rats fed with JAE than in the control group. Given these results, under healthy conditions, JAE dietary supplementation could perform in vivo modulation of gut microbiota, without disturbing the antioxidant system. Practical application Jaboticaba (Plinia jaboticaba) peel is a rich and often‐wasted source of bioactive compounds, such as polyphenols. Previous studies have shown that physiological benefits of this berry. The jaboticaba peel could contribute to antioxidant defense systems; it may also have an effect over gut microbiota related to polyphenols contents. Aqueous extraction may be a practical way of employing the bioactive compounds of jaboticaba peel; these compounds can be consumed daily and safely, and thus have attracted particular attention. This work showed positive impacts of jaboticaba peel treatments on microbiota and antioxidant defense systems, and could guide future clinical studies.

Organic brown sugar and jaboticaba pulp influence on water kefir fermentation

“…It shows potential to eliminate certain microorganisms such as Salmonella (Radkowski;Zdrodowska;Gomółka-Pawlicka, 2018). The addition of jaboticaba skin extract increased the microbiota of the stomach of rats, especially Lactobacillus, Bifidobacterium and Enterobacteriaceae (Silva-Maia et al, 2018). Our results show an influence of jaboticaba on the 33 times increase of succinic acid amount (Table 2).…”

“…The anti-radical activity is linked to the inhibition of enzymes associated with reactive oxygen (ROS) production, direct quenching of free radicals, chelation of transition metals, or redox inactivation of ROS. Additional attributes of phenolic compounds include modulating the gut microbiota and its metabolites, such as short chain fatty acids (SCFA), which improves glucose tolerance, appetite control, reduction of gut absorption, and lipid synthesis on liver (Silva-Maia et al, 2018).…”

Effects of Anthocyanin on Intestinal Health: A Systematic Review

“…Most of them were conducted in China ( n = 9) [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ] or the United States of America (U.S.A.) ( n = 5) [ 26 , 27 , 28 , 29 , 30 ]. Regarding the animal model used in the studies, 15 were performed with mice [ 17 , 20 , 21 , 22 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ], 11 with rats [ 18 , 19 , 23 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ] and only 1 with rabbits [ 43 ]. Most studies used male animals ( n = 24) [ 17 , 18 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ,…”

Myricetin and its derivative M10, myricetin-3-O-β-d-lactose sodium salt, modify the composition of gut microbiota in mice with chronic ulcerative colitis

“…Numerous studies showed that Myricetin exhibits diverse pharmacological properties including anti-chronic in ammation, anticarcinogenesis and angiogenesis, and even prevention of cancers [14][15][16]. Recently, Myricetin was found to have the biological activity of modulation gut microbiota in rats [17]. However, Myricetin does not meet the requirements as a therapeutic drug because of substantial limitations, such as complex isolation procedures, poor water solubility (< 100 ng/ml) and low bioavailability [18].…”