Effects of Isradipine on Peripheral Hemodynamic Reflex Responses in Mild-to-Moderate Essential Hypertension

Duprez, Daniel; Backer, Tine De; Pue, N. De; Hermans, Linda; Buyzere, Marc De; Clément, Denis

doi:10.1093/ajh/4.2.194s

Cited by 3 publications

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“…Felodipine and isradipine are blood vessel selective dihydropyridine calcium channel blockers with elimination half-lives of 25 and 8 h, respectively. Medication for 4 weeks with felodipine [12] and 6 weeks with isradipine [13] decreased the systolic and diastolic blood pressures of hypertensive patients in cold pressor tests. The rise of blood pressure induced by cold was lower after 6 weeks of medication with isradipine than without medication [13].…”

Section: Discussionmentioning

confidence: 99%

“…Medication for 4 weeks with felodipine [12] and 6 weeks with isradipine [13] decreased the systolic and diastolic blood pressures of hypertensive patients in cold pressor tests. The rise of blood pressure induced by cold was lower after 6 weeks of medication with isradipine than without medication [13]. Apart from the fact that we used a different calcium channel blocker, there were also other differences between designs of the previous studies and the present study.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Amlodipine on Blood Pressure Responses in Local and Whole-body Cooling in Normotensive Men

Tähtinen

Määttä²,

Rintamäki³

et al. 2011

Arzneimittelforschung

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The objective of this study was to determine the ability of amlodipine (CAS 88150-42-9, Norvasc) to affect the cold-induced rise of blood pressure and heart rate in normotensive men. Fourteen normotensive men underwent a one-hand cold pressor test (+10 degrees C, 5 min) and a whole-body cold air exposure test (+5 degrees C, 45 min) in a crossover study with and without amlodipine at a seven-day interval. Amlodipine decreased the levels of initial systolic and diastolic blood pressure before both tests, but it had no influence on heart rate. During the cold pressor test, amlodipine lowered the peak diastolic pressure from 96 +/- 10 mmHg (mean +/- SD) to 92 +/- 10 mmHg (p = 0.024). The rise of diastolic blood pressure was 13 +/- 7 mmHg with amlodipine and 16 +/- 8 mmHg without amlodipine (p = 0.138). During the whole-body cold air exposure test, amlodipine decreased the systolic pressure from 135 +/- 2 mmHg to 133 +/- 3 mmHg (p = 0.008) and the diastolic pressure from 88 +/- 2 mmHg to 86 +/- 1 mmHg (p = 0.005). However, the cold-induced rise of blood pressure in whole-body cooling was not affected by amlodipine, because it also decreased the initial values. Amlodipine did not affect the initial or cold-induced changes of heart rate in these tests. In conclusion, in normotensive men amlodipine lowers the peak of diastolic blood pressure in a cold pressor test. In whole-body cold air exposure, amlodipine slightly decreases the levels of both systolic and diastolic pressures, but has no effect on the cold-induced rise of blood pressure. Amlodipine does not prevent the cold-induced physiological responses of blood pressure or heart rate.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Amlodipine on Blood Pressure Responses in Local and Whole-body Cooling in Normotensive Men

Tähtinen

Määttä²,

Rintamäki³

et al. 2011

Arzneimittelforschung

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Twenty-Four Hour Profile of the Anti-hypertensive Action of Isradipine in Essential Hypertension

et al. 1993

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Isradipine, 2.5 mg twice daily and placebo were administered for 4 weeks to 11 untreated essential hypertensives in a double-blind, random order, crossover study. At the end of each phase patients were assessed by 36 h of continuous intra-arterial blood pressure monitoring, surface electrocardiography, and measurement of endogenous creatinine clearance, serum biochemistry and plasma renin activity. Arterial pressure was significantly reduced by isradipine, with mean reduction in systolic blood pressure of 11.0 mmHg and diastolic pressure of 13.2 mmHg over 24 h. There was no significant change in heart rate, endogenous creatinine clearance, serum biochemistry or plasma renin activity.

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Effect of antihypertensive drugs on blood pressure during exposure to cold. Experimental study in normotensive and hypertensive subjects

Komulainen¹

2007

International Journal of Circumpolar Health

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Effects of Isradipine on Peripheral Hemodynamic Reflex Responses in Mild-to-Moderate Essential Hypertension

Cited by 3 publications

References 0 publications

Effect of Amlodipine on Blood Pressure Responses in Local and Whole-body Cooling in Normotensive Men

Effect of Amlodipine on Blood Pressure Responses in Local and Whole-body Cooling in Normotensive Men

Twenty-Four Hour Profile of the Anti-hypertensive Action of Isradipine in Essential Hypertension

Effect of antihypertensive drugs on blood pressure during exposure to cold. Experimental study in normotensive and hypertensive subjects

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