Effects of Iron Overload on Hepatic and Renal Metallothionein Levels in Rats

Yasutake, Akira; Hirayama, Kazutsugu

doi:10.1248/jhs.50.372

Cited by 17 publications

(2 citation statements)

References 22 publications

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“…Yasutake and Hirayama [ 43 ] reported that the addition of 3.5% Fe(II) fumarate to the diet caused enhanced oxidative status in the liver and kidney, manifested by increased TBARS levels, as well as tissue Fe accumulations in male Wistar rats.…”

Section: Discussionmentioning

confidence: 99%

The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats

Staniek

Wójciak

2017

Biol Trace Elem Res

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Inadequate iron supply has significant consequences to health. There are some relations between the metabolism of different trace elements, such as iron, zinc, copper and chromium. However, the direction of these interactions can be antagonistic or synergistic, and it depends on many factors. The aim of the study was to evaluate the combined effects of supplementary of chromium(III) propionate complex (Cr3) with iron excess on the Cr and Fe status in healthy female rats. The 36 healthy female Wistar rats were divided into six experimental groups (six animals in each) with different Fe levels—adequate (45 mg kg−1—100% RDA) and high (excessive—180 mg kg−1—400% RDA). At the same time, they were supplemented with Cr(III) at doses of 1, 50 and 500 mg kg−1 of diet: C1—control (Fe 45 mg kg−1, Cr 1 mg kg−1); C50 (Fe 45 mg kg−1, Cr 50 mg kg−1); C500 (Fe 45 mg kg−1, Cr 500 mg kg−1); H1 (Fe 180 mg kg−1, Cr 1 mg kg−1); H50 (Fe 180 mg kg−1, Cr 50 mg kg−1); H500 (Fe 180 mg kg−1, Cr 500 mg kg−1). The serum iron level and total iron binding capacity (TIBC) were measured with colorimetric methods. The serum ferritin level was measured by means of electrochemiluminescence immunoassay. The serum transferrin level was measured with the ELISA method. Haematological measurements were made with an automated blood analyser. The Cr and Fe tissular levels were measured with the AAS method. The exposure to a high level of Fe(III) alone or in combination with Cr caused Fe accumulation in tissues, especially in the liver and kidneys, but there were no significant changes in the TIBC, transferrin, ferritin concentration in the serum and most haematological parameters. Moreover, the serum, hepatic and renal Cr concentrations decreased. The doses of supplementary Cr(III) given separately or in combination with high level of Fe(III) disturbed the Cr content in the liver and kidneys of healthy female rats. However, they did not change most of the parameters of Fe metabolism, except the Fe kidney concentration. Supplementary Cr3 decreased the renal Fe level in groups with adequate Fe content in the diet. However, the renal Fe levels increased along with a higher Cr level in the diet in groups with high Fe content. The findings proved a relationship between Fe(III) and Cr(III) metabolism in healthy female rats. However, the direction of change varied and depended on relative amounts of these elements in the diet.

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Section: Discussionmentioning

confidence: 99%

The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats

Staniek

Wójciak

2017

Biol Trace Elem Res

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“…A higher percentage of excess exposures is found in Japan where more fish is consumed, and 73.3% of women have hair Hg levels above 1.0 µg g −1 , and 1.7% above 5 µg g −1 . [44] The exposure depends not only on the frequency of fish intake and the size of each meal, but also on the species consumed. High concentrations of MeHg can be found in predatory fish and marine mammals in the top trophic levels, as MeHg biomagnifies in the aquatic food chains.…”

Section: New Zealandmentioning

confidence: 99%

Methylmercury exposure and health effects in humans

Choi¹,

Grandjean

2008

Environ. Chem.

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Environmental context. Dietary intake of fish and other seafood products is the dominant source of human exposure to methylmercury, a toxicant that can have serious adverse effects on the developing nervous system and may promote heart diseases. The existing evidence of human toxicity should inspire prudent choices in maintaining fish intakes to secure an ample supply of essential nutrients, while at the same time choosing species that are low in mercury concentrations. The combination of essential nutrients and avoidance of this toxic contaminant will benefit brain development and human health in general. In addition, current contamination levels suggest that intensified efforts are needed to reduce and eliminate mercury release to the environment.Abstract. Methylmercury (MeHg) is a worldwide contaminant found in seafood and freshwater fish, which constitute the dominant source of human exposure to this substance. The developing human brain is particularly susceptible to injury caused by MeHg, which easily passes the placental barrier. Epidemiological studies in fishing populations have found subtle though lasting adverse effects on brain functions of children who were exposed prenatally to MeHg from seafood diets. This contaminant also seems capable of promoting the development of heart disease. Fish and seafood also contain important nutrients, such as omega-3 fatty acids that may provide beneficial effects, thereby possibly counteracting or obscuring the adverse effects of MeHg. This article reviews the existing evidence on MeHg developmental neurotoxicity and the emerging evidence that MeHg may promote the development of heart diseases. MeHg risks may have been underestimated in the past, in part because of the confounding effects of nutrients from seafood and fish. Improved control of mercury release to the environment is indicated. In addition, regulatory agencies should provide better guidance to consumers in maintaining a balanced diet that includes seafood as low as possible in mercury.

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